Promothiocin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592439

CAS#: 156737-05-2

Description: Promothiocin A is an antibiotic.

Chemical Structure

Promothiocin A
CAS# 156737-05-2

Theoretical Analysis

MedKoo Cat#: 592439
Name: Promothiocin A
CAS#: 156737-05-2
Chemical Formula: C36H46N11O8S2
Exact Mass: 824.2972
Molecular Weight: 824.95
Elemental Analysis: C, 52.41; H, 5.62; N, 18.68; O, 15.52; S, 7.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Promothiocin A; Antibiotic SF-2741A; Antibiotic SF 2741A; Antibiotic SF2741A

IUPAC/Chemical Name: Alaninamide, L-valyl-2-(aminomethyl)-5-methyl-4-oxazolecarbonyl-2-((1S)-1-aminoethyl)-4-thiazolecarbonyl-6-(2-((1S)-1-aminoethyl)-5-methyl-4-oxazolyl)-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydro-, (4->1)-lactam


InChi Code: InChI=1S/C36H46N11O8S2/c1-13(2)24-32(52)38-10-23-45-26(18(7)54-23)33(53)41-16(5)35-43-21(11-56-35)30(50)40-15(4)34-47-25(17(6)55-34)27-19(36-44-22(12-57-36)31(51)46-24)8-9-20(42-27)29(49)39-14(3)28(37)48/h8-9,12-13,15-18,21,23-26,34-35H,3,10-11H2,1-2,4-7H3,(H2,37,48)(H,38,52)(H,39,49)(H,40,50)(H,41,53)(H,46,51)/t15-,16-,17?,18?,21?,23?,24-,25?,26?,34?,35?/m0/s1

SMILES Code: Cc1c-2nc(o1)[C@@H](NC(=O)c3csc(n3)[C@@H](NC(=O)c4c(oc(n4)CNC(=O)[C@@H](NC(=O)c5csc(n5)-c6c2nc(cc6)C(=O)NC(=C)C(=O)N)C(C)C)C)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 824.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Habazettl J, Allan M, Jensen PR, Sass HJ, Thompson CJ, Grzesiek S. Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5498-507. doi: 10.1073/pnas.1412070111. Epub 2014 Dec 8. PubMed PMID: 25489067; PubMed Central PMCID: PMC4280590.

2: Takagi M, Motohashi K, Nagai A, Hashimoto J, Shin-Ya K. JBIR-83 and JBIR-84, new promothiocin derivatives, isolated from Streptomyces sp. RI19. J Antibiot (Tokyo). 2010 Jul;63(7):405-8. doi: 10.1038/ja.2010.66. Epub 2010 Jun 16. PubMed PMID: 20551986.

3: Yun BS, Hidaka T, Furihata K, Seto H. Promothiocins A and B novel thiopeptides with a tipA promoter inducing activity produced by Streptomyces sp. SF2741. J Antibiot (Tokyo). 1994 Apr;47(4):510-4. PubMed PMID: 8195055.