Laidlomycin propionate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598236

CAS#: 78734-47-1 (free)

Description: Laidlomycin propionate improves rate of gain and feed conversion in both steers and heifers.


Chemical Structure

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Laidlomycin propionate
CAS# 78734-47-1 (free)

Theoretical Analysis

MedKoo Cat#: 598236
Name: Laidlomycin propionate
CAS#: 78734-47-1 (free)
Chemical Formula: C40H66O13
Exact Mass: 754.4503
Molecular Weight: 754.95
Elemental Analysis: C, 63.64; H, 8.81; O, 27.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 78734-47-1 (free)   84799-02-0 (potassium)    

Synonym: Laidlomycin propionate;

IUPAC/Chemical Name: (2S,3R,4R)-4-((2S,5R,7S,8R,9S)-9-hydroxy-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-3,5-dimethyl-6-((propionyloxy)methyl)tetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-2-methyl-3-(propionyloxy)pentanoic acid

InChi Key: WCKFMTGGCBJGEZ-GLQQXDFUSA-N

InChi Code: InChI=1S/C40H66O13/c1-11-30(42)47-20-40(46)23(5)17-21(3)32(52-40)28-18-22(4)35(48-28)38(10)14-13-29(50-38)37(9)15-16-39(53-37)19-27(41)24(6)34(51-39)25(7)33(26(8)36(44)45)49-31(43)12-2/h21-29,32-35,41,46H,11-20H2,1-10H3,(H,44,45)/t21-,22-,23+,24+,25-,26-,27-,28+,29+,32-,33+,34-,35+,37-,38-,39+,40-/m0/s1

SMILES Code: CCC(OC[C@@]1(O)[C@H](C)C[C@H](C)[C@@H]([C@H]2C[C@H](C)[C@H]([C@]3(C)CC[C@H]([C@]4(C)CC[C@]5(C[C@H](O)[C@@H](C)[C@@H]([C@H]([C@@H](OC(CC)=O)[C@@H](C(O)=O)C)C)O5)O4)O3)O2)O1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 754.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Cernicchiaro N, Corbin M, Quinn M, Prouty F, Branine M, Renter DG. Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America. J Anim Sci. 2016 Apr;94(4):1662-76. doi: 10.2527/jas.2015-0086. PubMed PMID: 27136025.

2: Bauer ML, Herold DW, Britton RA, Stock RA, Klopfenstein TJ, Yates DA. Efficacy of laidlomycin propionate to reduce ruminal acidosis in cattle. J Anim Sci. 1995 Nov;73(11):3445-54. PubMed PMID: 8586605.

3: Bohnert DW, Harmon DL, Dawson KA, Larson BT, Richards CJ, Streeter MN. Efficacy of laidlomycin propionate in low-protein diets fed to growing beef steers: effects on steer performance and ruminal nitrogen metabolism. J Anim Sci. 2000 Jan;78(1):173-80. PubMed PMID: 10682819.

4: Domescik EJ, Martin SA. Effects of laidlomycin propionate and monensin on the in vitro mixed ruminal microorganism fermentation. J Anim Sci. 1999 Aug;77(8):2305-12. PubMed PMID: 10462011.

5: Edrington TS, Callaway TR, Varey PD, Jung YS, Bischoff KM, Elder RO, Anderson RC, Kutter E, Brabban AD, Nisbet DJ. Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro. J Appl Microbiol. 2003;94(2):207-13. PubMed PMID: 12534812.

6: Galyean ML, Malcolm KJ, Duff GC. Performance of feedlot steers fed diets containing laidlomycin propionate or monensin plus tylosin, and effects of laidlomycin propionate concentration on intake patterns and ruminal fermentation in beef steers during adaptation to a high-concentrate diet. J Anim Sci. 1992 Oct;70(10):2950-8. PubMed PMID: 1429270.

7: Spires HR, Olmsted A, Berger LL, Fontenot JP, Gill DR, Riley JG, Wray MI, Zinn RA. Efficacy of laidlomycin propionate for increasing rate and efficiency of gain by feedlot cattle. J Anim Sci. 1990 Oct;68(10):3382-91. PubMed PMID: 2254209.

8: Edrington TS, Callaway TR, Bischoff KM, Genovese KJ, Elder RO, Anderson RC, Nisbet DJ. Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium. J Anim Sci. 2003 Feb;81(2):553-60. PubMed PMID: 12643501.

9: Wampler JL, Martin SA, Hill GM. Effects of laidlomycin propionate and monensin on glucose utilization and nutrient transport by Streptococcus bovis and Selenomonas ruminantium. J Anim Sci. 1998 Oct;76(10):2730-6. PubMed PMID: 9814916.

10: Zinn RA, Shen Y, Adam CF, Tamayo M, Rosalez J. Influence of dietary magnesium level on metabolic and growth-performance responses of feedlot cattle to laidlomycin propionate. J Anim Sci. 1996 Jul;74(7):1462-9. PubMed PMID: 8818789.

11: Fan YK, Croom J, Eisen EJ, Spires HR, Daniel LR. Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice. J Anim Sci. 2003 Aug;81(8):2072-9. PubMed PMID: 12926789.

12: Humphry JB, Coffey KP, Moyert JL, Brazle FK, Lomas LW. Intake, digestion, and digestive characteristics of Neotyphodium coenophialum-infected and uninfected fescue by heifers offered hay diets supplemented with Aspergillus oryzae fermentation extract or laidlomycin propionate. J Anim Sci. 2002 Jan;80(1):225-34. PubMed PMID: 11831521.

13: Ramirez JE, Alvarez EG, Montaño M, Shen Y, Zinn RA. Influence of dietary magnesium level on growth-performance and metabolic responses of Holstein steers to laidlomycin propionate. J Anim Sci. 1998 Jul;76(7):1753-9. PubMed PMID: 9690629.

14: Thompson AJ, Smith ZK, Corbin MJ, Harper LB, Johnson BJ. Ionophore strategy affects growth performance and carcass characteristics in feedlot steers. J Anim Sci. 2016 Dec;94(12):5341-5349. doi: 10.2527/jas.2016-0841. PubMed PMID: 28046158.

15: Zinn RA, Alvarez EG, Montaño MF, Ramirez JE. Interaction of protein nutrition and laidlomycin on feedlot growth performance and digestive function in Holstein steers. J Anim Sci. 2000 Jul;78(7):1768-78. PubMed PMID: 10907818.

16: Clark RD, Maddox ML, Spires HR, Long PL. Laidlomycin phenylcarbamate, a semisynthetic polyether antibiotic. J Antibiot (Tokyo). 1986 Dec;39(12):1765-8. PubMed PMID: 3818449.

17: Quinn MJ, May ML, Hales KE, DiLorenzo N, Leibovich J, Smith DR, Galyean ML. Effects of ionophores and antibiotics on in vitro hydrogen sulfide production, dry matter disappearance, and total gas production in cultures with a steam-flaked corn-based substrate with or without added sulfur. J Anim Sci. 2009 May;87(5):1705-13. doi: 10.2527/jas.2008-1549. Epub 2009 Feb 11. PubMed PMID: 19213713.

18: Campbell CG, Titgemeyer EC, Cochran RC, Nagaraja TG, Brandt RT Jr. Free amino acid supplementation to steers: effects on ruminal fermentation and performance. J Anim Sci. 1997 Apr;75(4):1167-78. PubMed PMID: 9110233.