WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598208
CAS#: 43000-65-3
Description: Lactandrate is a homo-aza-steroidal ester of p-bis(2-chloroethyl) amino phenyl acetic acid.
MedKoo Cat#: 598208
Name: Lactandrate
CAS#: 43000-65-3
Chemical Formula: C31H44Cl2N2O3
Exact Mass: 562.2729
Molecular Weight: 563.6
Elemental Analysis: C, 66.06; H, 7.87; Cl, 12.58; N, 4.97; O, 8.52
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Synonym: Lactandrate; NSC 290205; NSC-290205; NSC290205; ASE; NSC 620482; NSC-620482; NSC620482;
IUPAC/Chemical Name: (4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 2-(4-(bis(2-chloroethyl)amino)phenyl)acetate
InChi Key: JMZJBCNHUJOLER-AYQCGTONSA-N
InChi Code: InChI=1S/C31H44Cl2N2O3/c1-30-13-11-24(38-29(37)19-21-3-6-23(7-4-21)35(17-15-32)18-16-33)20-22(30)5-8-25-26(30)12-14-31(2)27(25)9-10-28(36)34-31/h3-4,6-7,22,24-27H,5,8-20H2,1-2H3,(H,34,36)/t22-,24-,25+,26-,27-,30-,31-/m0/s1
SMILES Code: C[C@]12CC[C@H]3[C@H]([C@@H]1CCC(N2)=O)CC[C@H]4C[C@@H](OC(Cc5ccc(N(CCCl)CCCl)cc5)=O)CC[C@]34C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 563.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Trafalis DT, Geromichalos GD, Koukoulitsa C, Papageorgiou A, Karamanakos P, Camoutsis C. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. Epub 2005 Dec 1. PubMed PMID: 16319980.
2: Trafalis DT, Geromichalos GD, Bountouroglou N, Koumbi D, Kontos M, Sougias D, Dalezis P, Karamanakos P, Papageorgiou A, Camoutsis C, Athanassiou AE. A preclinical survey on the efficacy of lactandrate in the treatment of colon carcinoma. J BUON. 2005 Apr-Jun;10(2):227-34. PubMed PMID: 17343334.
3: Trafalis DT. Hybrid aza-steroid alkylators in the treatment of colon cancer. Cancer Lett. 2006 Nov 18;243(2):202-10. Epub 2006 Jan 18. PubMed PMID: 16412564.
