Lacidipine
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MedKoo CAT#: 598202

CAS#: 103890-78-4

Description: Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery. It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea. Lacidipine induces negative inotropy in isolated guinea pig ventricular strips. It reduces mean blood pressure in spontaneously hypertensive rats and in renal hypertensive dogs with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.


Chemical Structure

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Lacidipine
CAS# 103890-78-4

Theoretical Analysis

MedKoo Cat#: 598202
Name: Lacidipine
CAS#: 103890-78-4
Chemical Formula: C26H33NO6
Exact Mass: 455.2308
Molecular Weight: 455.55
Elemental Analysis: C, 68.55; H, 7.30; N, 3.07; O, 21.07

Price and Availability

Size Price Availability Quantity
100.0mg USD 260.0 2 Weeks
250.0mg USD 460.0 2 Weeks
500.0mg USD 750.0 2 Weeks
1.0g USD 1400.0 2 Weeks
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Synonym: Lacidipine; Lacipil; Lacimen; Motens; GR 43659 X; GR-43659 X; GR43659 X;

IUPAC/Chemical Name: diethyl (E)-4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: GKQPCPXONLDCMU-CCEZHUSRSA-N

InChi Code: InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+

SMILES Code: O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC=C2/C=C/C(OC(C)(C)C)=O)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 455.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Micheli, D., Collodel, A., Semeraro, C., et al. Lacidipine: A calcium antagonist with potent and long-lasting antihypertensive effects in animal studies. J. Cardiovasc. Parmacol. 15(4), 666-675 (1990).

2. Lupo, E., Locher, R., Weisser, B., et al. In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with α-tocopherol. Biochem. Biophys. Res. Commun. 203(3), 1803-1808 (1994).

3. Kyselovic, J., Martinka, P., Batova, Z., et al. Calcium channel blocker inhibits Western-type diet-evoked atherosclerosis development in ApoE-deficient mice. J. Pharmacol. Exp. Ther. 315(1), 320-328 (2005).

Lacidipine

100.0mg / USD 260.0