NVP-AAD777

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MedKoo CAT#: 563400

CAS#: 300842-59-5

Description: NVP-AAD777 is a specific inhibitor of VEGFR-2.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-26. Prices are subject to change without notice.

NVP-AAD777 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563400
Name: NVP-AAD777
CAS#: 300842-59-5
Chemical Formula: C22H14F6N4
Exact Mass: 448.1123
Molecular Weight: 448.37
Elemental Analysis: C, 58.93; H, 3.15; F, 25.42; N, 12.50


Synonym: NVP-AAD777; NVP AAD777; NVP-AAD-777; NVP AAD 777; NVPAAD777; AAD-777; ZK-202664; AAD 777; ZK 202664; AAD777; ZK202664;

IUPAC/Chemical Name: N-[3,4-Bis(trifluoromethyl)phenyl]-4-(pyridin-4-ylmethyl)phthalazin-1-amine

InChi Key: BSIYFOACHNHUPJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H14F6N4/c23-21(24,25)17-6-5-14(12-18(17)22(26,27)28)30-20-16-4-2-1-3-15(16)19(31-32-20)11-13-7-9-29-10-8-13/h1-10,12H,11H2,(H,30,32)

SMILES Code: FC(C1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1C(F)(F)F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul;22(7):2297-310. doi: 10.1096/fj.07-099481. Epub 2008 Feb 8. PubMed PMID: 18263699; PubMed Central PMCID: PMC4708085.

2: Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L897-908. Epub 2005 Dec 16. PubMed PMID: 16361360.