Lachesine chloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598197

CAS#: 1164-38-1

Description: Lachesine chloride is a new mydriatic.


Chemical Structure

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Lachesine chloride
CAS# 1164-38-1

Theoretical Analysis

MedKoo Cat#: 598197
Name: Lachesine chloride
CAS#: 1164-38-1
Chemical Formula: C20H26ClNO3
Exact Mass:
Molecular Weight: 363.88
Elemental Analysis: C, 66.02; H, 7.20; Cl, 9.74; N, 3.85; O, 13.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Lachesine chloride; Lachesine; Laxesin;

IUPAC/Chemical Name: N-ethyl-2-(2-hydroxy-2,2-diphenylacetoxy)-N,N-dimethylethan-1-aminium chloride

InChi Key: TVCAZGSWNBZVJN-UHFFFAOYSA-M

InChi Code: InChI=1S/C20H26NO3.ClH/c1-4-21(2,3)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,4,15-16H2,1-3H3;1H/q+1;/p-1

SMILES Code: C[N+](CC)(CCOC(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)=O)C.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 363.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: FELDMAN JB. E-3--Lachesine. Am J Ophthalmol. 1951 Mar;34(3):442-3. PubMed PMID: 14819163.

2: ING HR. Lachesine, a new mydriatic. Br J Ophthalmol. 1946 Apr;30:247. PubMed PMID: 21023080.

3: LAW BB. Atropine and lachesine. Pharm J. 1946 Oct 5;103(4327):215. PubMed PMID: 21002928.

4: Reasbeck PG, Young JM. Interaction of benzilylcholine mustard, benzilylcholine and lachesine with the histamine receptor in the longitudinal muscle of guinea-pig ileum. Br J Pharmacol. 1973 May;48(1):148-55. PubMed PMID: 4724186; PubMed Central PMCID: PMC1776109.

5: Ing HR, Wright RE. LACHESINE, A NEW MYDRIATIC. Br J Ophthalmol. 1946 Apr;30(4):247-50. PubMed PMID: 18170215; PubMed Central PMCID: PMC510598.

6: RANG HP. STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1964 Apr;22:356-65. PubMed PMID: 14190470; PubMed Central PMCID: PMC1703977.

7: Brown DA, Fatherazi S, Garthwaite J, White RD. Muscarinic receptors in rat sympathetic ganglia. Br J Pharmacol. 1980 Dec;70(4):577-92. PubMed PMID: 6258681; PubMed Central PMCID: PMC2044374.

8: Attwood D. Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1976 May;28(5):407-9. PubMed PMID: 6747.

9: Stubbins JF, Hudgins PM, Murphy DC. Antimuscarinic agents: furan analogs of benzilate esters. J Pharm Sci. 1980 May;69(5):534-7. PubMed PMID: 7381738.

10: King KT, Ryall RW. A re-evaluation of acetylcholine receptors on feline Renshaw cells. Br J Pharmacol. 1981 Jun;73(2):455-60. PubMed PMID: 7236994; PubMed Central PMCID: PMC2071653.

11: CUTHBERT AW. SOME EFFECTS OF ATROPINE ON SMOOTH MUSCLE. Br J Pharmacol Chemother. 1963 Oct;21:285-94. PubMed PMID: 14081659; PubMed Central PMCID: PMC1703824.

12: Eickhoff R, Bicker G. Developmental expression of cell recognition molecules in the mushroom body and antennal lobe of the locust Locusta migratoria. J Comp Neurol. 2012 Jun 15;520(9):2021-40. doi: 10.1002/cne.23026. PubMed PMID: 22173776.

13: Malaterre J, Strambi C, Chiang AS, Aouane A, Strambi A, Cayre M. Development of cricket mushroom bodies. J Comp Neurol. 2002 Oct 21;452(3):215-27. PubMed PMID: 12353218.

14: Selivanova AT, Zemliankin AS. [Role of the central and peripheral cholinoreceptors in the processes of short-term memory]. Farmakol Toksikol. 1975 Nov-Dec;38(6):647-50. Russian. PubMed PMID: 819297.

15: Karlstrom RO, Wilder LP, Bastiani MJ. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Development. 1993 Jun;118(2):509-22. PubMed PMID: 8223276.