WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598189
CAS#: 89900-49-2
Description: Labdane F2 is a thromboxane B2 and leukotriene B4 antagonist isolated from the Spanish herb Sideritis javalambrensis.
MedKoo Cat#: 598189
Name: Labdane F2
CAS#: 89900-49-2
Chemical Formula: C20H34O
Exact Mass: 290.261
Molecular Weight: 290.49
Elemental Analysis: C, 82.69; H, 11.80; O, 5.51
This product is not in stock, which may be available by custom synthesis.
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Synonym: Labdane F2;
IUPAC/Chemical Name: (1R,2S,4aR,8aR)-2,5,5,8a-tetramethyl-1-(3-methylenepent-4-en-1-yl)decahydronaphthalen-2-ol
InChi Key: JTWQQJDENGGSBJ-LFGUQSLTSA-N
InChi Code: InChI=1S/C20H34O/c1-7-15(2)9-10-17-19(5)13-8-12-18(3,4)16(19)11-14-20(17,6)21/h7,16-17,21H,1-2,8-14H2,3-6H3/t16-,17-,19-,20+/m1/s1
SMILES Code: O[C@]1(C)[C@H](CCC(C=C)=C)[C@]2(C)CCCC(C)(C)[C@@]2([H])CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 290.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Pang L, de las Heras B, Hoult JR. A novel diterpenoid labdane from Sideritis javalambrensis inhibits eicosanoid generation from stimulated macrophages but enhances arachidonate release. Biochem Pharmacol. 1996 Mar 22;51(6):863-8. PubMed PMID: 8602884.
2: Roengsumran S, Petsom A, Kuptiyanuwat N, Vilaivan T, Ngamrojnavanich N, Chaichantipyuth C, Phuthong S. Cytotoxic labdane diterpenoids from Croton oblongifolius. Phytochemistry. 2001 Jan;56(1):103-7. PubMed PMID: 11198816.
3: Kalpoutzakis E, Aligiannis N, Mitaku S, Chinou I, Harvala C, Skaltsounis AL. New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus. Z Naturforsch C. 2001 Jan-Feb;56(1-2):49-52. PubMed PMID: 11302213.
4: de las Heras B, Villar A, Vivas JM, Hoult JR. Novel anti-inflammatory plant labdanes: comparison of in vitro properties with aspirin and indomethacin. Agents Actions. 1994 Mar;41(1-2):114-7. PubMed PMID: 8079815.
5: Ono M, Yamamoto M, Yanaka T, Ito Y, Nohara T. Ten new labdane-type diterpenes from the fruit of Vitex rotundifolia. Chem Pharm Bull (Tokyo). 2001 Jan;49(1):82-6. PubMed PMID: 11201231.
6: de las Heras B, Hoult JR. Non-cytotoxic inhibition of macrophage eicosanoid biosynthesis and effects on leukocyte functions and reactive oxygen species of two novel anti-inflammatory plant diterpenoids. Planta Med. 1994 Dec;60(6):501-6. PubMed PMID: 7809200.
