WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598188
CAS#: 88630-25-5
Description: Lab 170250F is a potent inhibitor of cytochrome P-450-obtusifoliol-14-demethylase.
MedKoo Cat#: 598188
Name: Lab 170250F
CAS#: 88630-25-5
Chemical Formula: C17H14ClN3O
Exact Mass: 311.0825
Molecular Weight: 311.76
Elemental Analysis: C, 65.49; H, 4.53; Cl, 11.37; N, 13.48; O, 5.13
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Lab 170250F; Lab-170250F; Lab170250F;
IUPAC/Chemical Name: 1-((2-(4-chlorophenyl)-3-phenyloxiran-2-yl)methyl)-1H-1,2,4-triazole
InChi Key: YGLGKNIVFJHGIW-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H14ClN3O/c18-15-8-6-14(7-9-15)17(10-21-12-19-11-20-21)16(22-17)13-4-2-1-3-5-13/h1-9,11-12,16H,10H2
SMILES Code: ClC1=CC=C(C2(CN3N=CN=C3)OC2C4=CC=CC=C4)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 311.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Grausem B, Chaubet N, Gigot C, Loper JC, Benveniste P. Functional expression of Saccharomyces cerevisiae CYP51A1 encoding lanosterol-14-demethylase in tobacco results in bypass of endogenous sterol biosynthetic pathway and resistance to an obtusifoliol-14-demethylase herbicide inhibitor. Plant J. 1995 May;7(5):761-70. PubMed PMID: 7773307.
2: Maillot-Vernier P, Schaller H, Benveniste P, Belliard G. Biochemical characterization of a sterol mutant plant regenerated from a tobacco callus resistant to a triazole cytochrome-P-450-obtusifoliol-14-demethylase inhibitor. Biochem Biophys Res Commun. 1989 Nov 30;165(1):125-30. PubMed PMID: 2590214.
3: Maillot-Vernier P, Gondet L, Schaller H, Benveniste P, Belliard G. Genetic study and further biochemical characterization of a tobacco mutant that overproduces sterols. Mol Gen Genet. 1991 Dec;231(1):33-40. PubMed PMID: 1753944.
