T62
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563393

CAS#: 40312-34-3

Description: T62 is an allosteric enhancer of A1 adenosine receptor.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 288 2 Weeks
25mg USD 519 2 Weeks
50mg USD 840 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-02. Prices are subject to change without notice.

T62, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 563393
Name: T62
CAS#: 40312-34-3
Chemical Formula: C15H14ClNOS
Exact Mass: 291.0485
Molecular Weight: 291.79
Elemental Analysis: C, 61.74; H, 4.84; Cl, 12.15; N, 4.80; O, 5.48; S, 10.99


Synonym: T62; T-62; T 62;

IUPAC/Chemical Name: (2-Amino-4,5,6,7-tetrahydrobenzo[b]thien-3-yl)(4-chlorophenyl)methanone

InChi Key: OTZVBZFYMFTYKH-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14ClNOS/c16-10-7-5-9(6-8-10)14(18)13-11-3-1-2-4-12(11)19-15(13)17/h5-8H,1-4,17H2

SMILES Code: O=C(C1=C(N)SC2=C1CCCC2)C3=CC=C(Cl)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Wang J, Xu J, Luo S, Ma Z, Bechthold A, Yu X. AdpA (sd) , a Positive Regulator for Morphological Development and Toyocamycin Biosynthesis in Streptomyces diastatochromogenes 1628. Curr Microbiol. 2018 Jun 19. doi: 10.1007/s00284-018-1529-6. [Epub ahead of print] PubMed PMID: 29922969.

2: Hedegaard H, Schoenbaum M, Claassen C, Crosby A, Holland K, Proescholdbell S. Issues in Developing a Surveillance Case Definition for Nonfatal Suicide Attempt and Intentional Self-harm Using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) Coded Data. Natl Health Stat Report. 2018 Feb;(108):1-19. PubMed PMID: 29616901.

3: Yoon WK, Kim YW, Suh SL, Choi R, Lee SG, Hyun C. Evaluation of cardiopulmonary and inflammatory markers in dogs with heartworm infection during treatment with the 2014 American Heartworm Society recommended treatment protocol. Parasit Vectors. 2017 Nov 9;10(Suppl 2):535. doi: 10.1186/s13071-017-2427-7. PubMed PMID: 29143684; PubMed Central PMCID: PMC5688508.

4: Seyedsadjadi N, Berg J, Bilgin AA, Tung C, Grant R. Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score. PLoS One. 2017 Nov 6;12(11):e0187713. doi: 10.1371/journal.pone.0187713. eCollection 2017. PubMed PMID: 29107974; PubMed Central PMCID: PMC5673171.

5: Nagano H, Shibano K, Matsumoto Y, Yokota A, Wada M. Isolation and amino acid sequence of a dehydratase acting on d-erythro-3-hydroxyaspartate from Pseudomonas sp. N99, and its application in the production of optically active 3-hydroxyaspartate. Biosci Biotechnol Biochem. 2017 Jun;81(6):1156-1164. doi: 10.1080/09168451.2017.1295804. Epub 2017 Mar 14. PubMed PMID: 28290777.

6: Ma Z, Luo S, Xu X, Bechthold A, Yu X. Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628. J Ind Microbiol Biotechnol. 2016 Apr;43(4):463-71. doi: 10.1007/s10295-015-1732-4. Epub 2016 Jan 20. PubMed PMID: 26790416.

7: Detert Oude Weme R, Seidel G, Kuipers OP. Probing the regulatory effects of specific mutations in three major binding domains of the pleiotropic regulator CcpA of Bacillus subtilis. Front Microbiol. 2015 Oct 2;6:1051. doi: 10.3389/fmicb.2015.01051. eCollection 2015. PubMed PMID: 26483775; PubMed Central PMCID: PMC4591507.

8: Hering-Junghans C, Rivard E. Accessing an Aromatic Diphosphatriazolate Anion by Formal Inorganic "Click" Chemistry. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10077-9. doi: 10.1002/anie.201505715. Epub 2015 Jul 15. PubMed PMID: 26190287.

9: Andersson E, Hedman E, Enander J, Radu Djurfeldt D, Ljótsson B, Cervenka S, Isung J, Svanborg C, Mataix-Cols D, Kaldo V, Andersson G, Lindefors N, Rück C. D-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Jul;72(7):659-67. doi: 10.1001/jamapsychiatry.2015.0546. PubMed PMID: 25970252.

10: Mangiatordi GF, Alberga D, Siragusa L, Goracci L, Lattanzi G, Nicolotti O. Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields. Biochim Biophys Acta. 2015 Jul;1848(7):1462-71. doi: 10.1016/j.bbamem.2015.03.019. Epub 2015 Mar 31. PubMed PMID: 25839357.

11: De Avila M, Vassall KA, Smith GS, Bamm VV, Harauz G. The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro. Biosci Rep. 2014 Dec 8;34(6):e00157. doi: 10.1042/BSR20140149. PubMed PMID: 25343306; PubMed Central PMCID: PMC4266924.

12: Loch TP, Faisal M. Chryseobacterium aahli sp. nov., isolated from lake trout (Salvelinus namaycush) and brown trout (Salmo trutta), and emended descriptions of Chryseobacterium ginsenosidimutans and Chryseobacterium gregarium. Int J Syst Evol Microbiol. 2014 May;64(Pt 5):1573-9. doi: 10.1099/ijs.0.052373-0. Epub 2014 Jan 30. PubMed PMID: 24480907.

13: Deng FY, Tan LJ, Shen H, Liu YJ, Liu YZ, Li J, Zhu XZ, Chen XD, Tian Q, Zhao M, Deng HW. SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans. J Bone Miner Res. 2013 Dec;28(12):2498-507. doi: 10.1002/jbmr.1997. PubMed PMID: 23712400; PubMed Central PMCID: PMC4127979.

14: Chen L, Zhang S, Banerjee AK, Chen M. N-terminal phosphorylation of phosphoprotein of vesicular stomatitis virus is required for preventing nucleoprotein from binding to cellular RNAs and for functional template formation. J Virol. 2013 Mar;87(6):3177-86. doi: 10.1128/JVI.02761-12. Epub 2013 Jan 2. PubMed PMID: 23283948; PubMed Central PMCID: PMC3592151.

15: Menon D, Stafinski T. Role of patient and public participation in health technology assessment and coverage decisions. Expert Rev Pharmacoecon Outcomes Res. 2011 Feb;11(1):75-89. doi: 10.1586/erp.10.82. Review. PubMed PMID: 21351860.

16: Lévesque S, Dombrowski C, Morel ML, Rehel R, Côté JS, Bussières J, Morgan K, Rousseau F. Screening and instability of FMR1 alleles in a prospective sample of 24,449 mother-newborn pairs from the general population. Clin Genet. 2009 Dec;76(6):511-23. doi: 10.1111/j.1399-0004.2009.01237.x. Epub 2009 Oct 23. PubMed PMID: 19863547.

17: Efendiev IN, Kobidze TS. [Regional features of acute chemical trauma in Azerbaijan and Georgia]. Georgian Med News. 2009 Feb;(167):102-8. Russian. PubMed PMID: 19276484.

18: Murakami T, Maeda T, Yokota A, Wada M. Gene cloning and expression of pyridoxal 5'-phosphate-dependent L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62, and characterization of the recombinant enzyme. J Biochem. 2009 May;145(5):661-8. doi: 10.1093/jb/mvp023. Epub 2009 Feb 4. PubMed PMID: 19193709.

19: Lee PW, Hefle SL, Taylor SL. Sandwich enzyme-linked immunosorbent assay (ELISA) for detection of mustard in foods. J Food Sci. 2008 May;73(4):T62-8. doi: 10.1111/j.1750-3841.2008.00725.x. PubMed PMID: 18460147.

20: Childers SR, Li X, Xiao R, Eisenach JC. Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain. J Neurochem. 2005 May;93(3):715-23. PubMed PMID: 15836630.