Necrostatin-7
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MedKoo CAT#: 563391

CAS#: 351062-08-3

Description: Necrostatin-7 is a necroptosis inhibitor. It acts by inhibiting TNF-alpha-induced necroptosis in a FADD-deficient variant of human Jurkat T cells.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 270 2 Weeks
25mg USD 590 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

Necrostatin-7, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563391
Name: Necrostatin-7
CAS#: 351062-08-3
Chemical Formula: C16H10FN5OS2
Exact Mass: 371.0311
Molecular Weight: 371.4
Elemental Analysis: C, 51.74; H, 2.71; F, 5.12; N, 18.86; O, 4.31; S, 17.26


Synonym: Necrostatin-7; Necrostatin 7; Necrostatin7; Nec-7; Nec 7; Nec7;

IUPAC/Chemical Name: 5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one

InChi Key: SMJGLNVGTJLIRV-KBEFMPHXSA-N

InChi Code: InChI=1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)/b12-7-,18-15?

SMILES Code: O=C1N(C2=NC=CS2)C(S/C1=C\C3=CNN=C3C4=CC=C(F)C=C4)=N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M. Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Biochem Biophys Res Commun. 2018 May 22. pii: S0006-291X(18)31224-5. doi: 10.1016/j.bbrc.2018.05.153. [Epub ahead of print] PubMed PMID: 29800570.

2: Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016 Mar 2;6:22538. doi: 10.1038/srep22538. PubMed PMID: 26932729; PubMed Central PMCID: PMC4773760.

3: Dmitriev YV, Karpov AA, Dracheva AV, Minasian SM, Chefu SG, Vasina LV, Demchenko EA, Galagudza IM. [CARDIOPROTFETIVE EFECTS OF NECROSTATIN-7 IN THE RAT MODEL OF PERMANENT CORONARY OCCLUSION]. Ross Fiziol Zh Im I M Sechenova. 2015 Apr;101(4):408-14. Russian. PubMed PMID: 26336739.

4: Zheng W, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5. doi: 10.1016/j.bmcl.2008.08.058. Epub 2008 Aug 22. PubMed PMID: 18768316.