WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563386

CAS#: 261717-18-4

Description: MSX-2 is a selective A2A adenosine receptor antagonist.

Chemical Structure

CAS# 261717-18-4

Theoretical Analysis

MedKoo Cat#: 563386
Name: MSX-2
CAS#: 261717-18-4
Chemical Formula: C21H22N4O4
Exact Mass: 394.1641
Molecular Weight: 394.43
Elemental Analysis: C, 63.95; H, 5.62; N, 14.20; O, 16.22

Price and Availability

Size Price Availability Quantity
5.0mg USD 340.0 2 Weeks
10.0mg USD 560.0 2 Weeks
25.0mg USD 1015.0 2 Weeks
50.0mg USD 2000.0 2 Weeks
100.0mg USD 3000.0 2 Weeks
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Synonym: MSX-2; MSX 2; MSX2;

IUPAC/Chemical Name: 3-(3-Hydroxy-propyl)-8-[2-(3-methoxy-phenyl)-vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione


InChi Code: InChI=1S/C21H22N4O4/c1-4-11-25-20(27)18-19(24(21(25)28)12-6-13-26)22-17(23(18)2)10-9-15-7-5-8-16(14-15)29-3/h1,5,7-10,14,26H,6,11-13H2,2-3H3/b10-9+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 394.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Becic T, Kero D, Vukojevic K, Mardesic S, Saraga-Babic M. Growth factors FGF8 and FGF2 and their receptor FGFR1, transcriptional factors Msx-1 and MSX-2, and apoptotic factors p19 and RIP5 participate in the early human limb development. Acta Histochem. 2018 Apr;120(3):205-214. doi: 10.1016/j.acthis.2018.01.008. Epub 2018 Feb 4. PubMed PMID: 29409666.

2: Gao Y, Wang X, Yan H, Zeng J, Ma S, Niu Y, Zhou G, Jiang Y, Chen Y. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. PLoS One. 2016 Mar 9;11(3):e0151118. doi: 10.1371/journal.pone.0151118. eCollection 2016. PubMed PMID: 26959817; PubMed Central PMCID: PMC4784850.

3: Zhao YG, Meng FX, Li BW, Sheng YM, Liu MM, Wang B, Li HW, Xiu RJ. Gelatinases promote calcification of vascular smooth muscle cells by up-regulating bone morphogenetic protein-2. Biochem Biophys Res Commun. 2016 Feb 5;470(2):287-293. doi: 10.1016/j.bbrc.2016.01.067. Epub 2016 Jan 13. PubMed PMID: 26797522.

4: Yin Y, Lin C, Zhang I, Fisher AV, Dhandha M, Ma L. Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol. J Stem Cell Transplant Biol. 2015;1(1). pii: 105. Epub 2015 May 12. PubMed PMID: 26457333; PubMed Central PMCID: PMC4596533.

5: Sun H, Liu Z, Li B, Dai J, Wang X. Effects of DLX2 overexpression on the osteogenic differentiation of MC3T3-E1 cells. Exp Ther Med. 2015 Jun;9(6):2173-2179. Epub 2015 Mar 20. PubMed PMID: 26136955; PubMed Central PMCID: PMC4473650.

6: Zhang Y, Yuan T, Li L, Nahar P, Slitt A, Seeram NP. Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications. J Agric Food Chem. 2014 Jul 16;62(28):6687-98. doi: 10.1021/jf501924y. Epub 2014 Jul 8. Erratum in: J Agric Food Chem. 2014 Sep 10;62(36):9057. PubMed PMID: 24983789; PubMed Central PMCID: PMC4334281.

7: Chistiakov DA, Sobenin IA, Orekhov AN, Bobryshev YV. Mechanisms of medial arterial calcification in diabetes. Curr Pharm Des. 2014;20(37):5870-83. Review. PubMed PMID: 24533933.

8: Atsawasuwan P, Lu X, Ito Y, Zhang Y, Evans CA, Luan X. Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation. PLoS One. 2013 Apr 4;8(4):e52800. doi: 10.1371/journal.pone.0052800. Print 2013. PubMed PMID: 23593111; PubMed Central PMCID: PMC3617155.

9: Schiedel AC, Lacher SK, Linnemann C, Knolle PA, Müller CE. Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms. Purinergic Signal. 2013 Sep;9(3):351-65. doi: 10.1007/s11302-013-9354-7. Epub 2013 Jan 29. PubMed PMID: 23359122; PubMed Central PMCID: PMC3757146.

10: Afara I, Prasadam I, Crawford R, Xiao Y, Oloyede A. Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation to Mankin score. Osteoarthritis Cartilage. 2012 Nov;20(11):1367-73. doi: 10.1016/j.joca.2012.07.007. Epub 2012 Jul 20. PubMed PMID: 22820498.

11: Santerre JL, Nunes EJ, Kovner R, Leser CE, Randall PA, Collins-Praino LE, Lopez Cruz L, Correa M, Baqi Y, Müller CE, Salamone JD. The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions. Pharmacol Biochem Behav. 2012 Oct;102(4):477-87. doi: 10.1016/j.pbb.2012.06.009. Epub 2012 Jun 15. PubMed PMID: 22705392.

12: Sun J, Li M, Kang RX, Shi JG, Zhang JJ. [Protective effect of new adenosine analog B2 against serum deprivation-induced PC12 cell injury]. Yao Xue Xue Bao. 2011 Oct;46(10):1199-203. Chinese. PubMed PMID: 22242450.

13: Orru M, Bakešová J, Brugarolas M, Quiroz C, Beaumont V, Goldberg SR, Lluís C, Cortés A, Franco R, Casadó V, Canela EI, Ferré S. Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. PLoS One. 2011 Jan 11;6(1):e16088. doi: 10.1371/journal.pone.0016088. PubMed PMID: 21264319; PubMed Central PMCID: PMC3019225.

14: Burns JS, Rasmussen PL, Larsen KH, Schrøder HD, Kassem M. Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential. Tissue Eng Part A. 2010 Jul;16(7):2331-42. doi: 10.1089/ten.TEA.2009.0735. PubMed PMID: 20196644.

15: Pritchett CE, Pardee AL, McGuirk SR, Will MJ. The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake. Brain Res. 2010 Jan 8;1306:85-92. doi: 10.1016/j.brainres.2009.09.115. Epub 2009 Oct 12. PubMed PMID: 19822132; PubMed Central PMCID: PMC4443807.

16: Osyczka AM, Damek-Poprawa M, Wojtowicz A, Akintoye SO. Age and skeletal sites affect BMP-2 responsiveness of human bone marrow stromal cells. Connect Tissue Res. 2009;50(4):270-7. doi: 10.1080/03008200902846262. PubMed PMID: 19637063; PubMed Central PMCID: PMC2905683.

17: Sihver W, Schulze A, Wutz W, Stüsgen S, Olsson RA, Bier D, Holschbach MH. Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results. Eur J Pharmacol. 2009 Aug 15;616(1-3):107-14. doi: 10.1016/j.ejphar.2009.06.025. Epub 2009 Jun 21. PubMed PMID: 19545560.

18: Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol. 2009 Jul;20(7):1453-64. doi: 10.1681/ASN.2008070692. Epub 2009 May 28. PubMed PMID: 19478096.

19: Koleganova N, Piecha G, Ritz E, Schirmacher P, Müller A, Meyer HP, Gross ML. Arterial calcification in patients with chronic kidney disease. Nephrol Dial Transplant. 2009 Aug;24(8):2488-96. doi: 10.1093/ndt/gfp137. Epub 2009 Mar 27. PubMed PMID: 19329792.

20: Itaya T, Kagami H, Okada K, Yamawaki A, Narita Y, Inoue M, Sumita Y, Ueda M. Characteristic changes of periodontal ligament-derived cells during passage. J Periodontal Res. 2009 Aug;44(4):425-33. doi: 10.1111/j.1600-0765.2008.01137.x. PubMed PMID: 18973549.


5.0mg / USD 340.0