WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563385
CAS#: 778649-18-6
Description: MB-3 is a histone acetyltransferase GCN5 inhibitor.
MedKoo Cat#: 563385
Name: MB-3
CAS#: 778649-18-6
Chemical Formula: C9H12O4
Exact Mass: 184.0736
Molecular Weight: 184.19
Elemental Analysis: C, 58.69; H, 6.57; O, 34.74
Synonym: MB-3; MB 3; MB3; Butyrolactone 3; Gcn5 Inhibitor 1; Butyrolactone-3; Gcn-5 Inhibitor-1;
IUPAC/Chemical Name: (2S,3R)-4-Methylidene-5-oxo-2-propyloxolane-3-carboxylic acid
InChi Key: SRQUTZJZABSZRQ-NKWVEPMBSA-N
InChi Code: InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
SMILES Code: O=C([C@H](C1=C)[C@H](CCC)OC1=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 184.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Becherer L, Bakheit M, Frischmann S, Stinco S, Borst N, Zengerle R, von Stetten F. Simplified Real-Time Multiplex Detection of Loop-Mediated Isothermal Amplification Using Novel Mediator Displacement Probes with Universal Reporters. Anal Chem. 2018 Apr 3;90(7):4741-4748. doi: 10.1021/acs.analchem.7b05371. Epub 2018 Mar 14. PubMed PMID: 29508609.
2: Chernikova TN, Kyrpides N, Bargiela R, Woyke T, Shapiro N, Whitman WB, Golyshin PN. Draft Genome Sequence of Monaibacterium marinum C7(T), Isolated from Seawater from the Menai Straits, Wales, United Kingdom. Genome Announc. 2018 Feb 1;6(5). pii: e01444-17. doi: 10.1128/genomeA.01444-17. PubMed PMID: 29437088; PubMed Central PMCID: PMC5794935.
3: Badawy AM, Eshra EA. Development of an ultrasound-guided technique for retrobulbar nerve block in dromedary camels: a cadaveric study. Vet Anaesth Analg. 2018 Mar;45(2):175-182. doi: 10.1016/j.vaa.2017.09.039. Epub 2017 Nov 7. PubMed PMID: 29415860.
4: Vidotto T, Tiezzi DG, Squire JA. Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer. Mol Cytogenet. 2018 Jan 3;11:1. doi: 10.1186/s13039-017-0348-y. eCollection 2018. PubMed PMID: 29308088; PubMed Central PMCID: PMC5753467.
5: Yamauchi M, Okada T, Okada T, Yamamoto A, Fushimi Y, Arakawa Y, Miyamoto S, Togashi K. Differential diagnosis of posterior fossa brain tumors: Multiple discriminant analysis of Tl-SPECT and FDG-PET. Medicine (Baltimore). 2017 Aug;96(33):e7767. doi: 10.1097/MD.0000000000007767. PubMed PMID: 28816956; PubMed Central PMCID: PMC5571693.
6: Chatterjee A, White JS, Hashim T, Leesar MA. Jailing polymer jacketed guide-wires during bifurcation coronary interventions is associated with procedural myocardial infarction. World J Cardiol. 2017 May 26;9(5):442-447. doi: 10.4330/wjc.v9.i5.442. PubMed PMID: 28603592; PubMed Central PMCID: PMC5442413.
7: Kriegmair MC, Bergen T, Ritter M, Mandel P, Michel MS, Wittenberg T, Bolenz C. Digital Mapping of the Urinary Bladder: Potential for Standardized Cystoscopy Reports. Urology. 2017 Jun;104:235-241. doi: 10.1016/j.urology.2017.02.019. Epub 2017 Feb 16. PubMed PMID: 28214573.
8: Wu Y, Ma S, Xia Y, Lu Y, Xiao S, Cao Y, Zhuang S, Tan X, Fu Q, Xie L, Li Z, Yuan Z. Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim. Cell Death Dis. 2017 Jan 26;8(1):e2570. doi: 10.1038/cddis.2016.465. PubMed PMID: 28125090; PubMed Central PMCID: PMC5386373.
9: Aquea F, Timmermann T, Herrera-Vásquez A. Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. Biochem Biophys Res Commun. 2017 Jan 29;483(1):664-668. doi: 10.1016/j.bbrc.2016.12.086. Epub 2016 Dec 18. PubMed PMID: 27993678.
10: Lee SW, Lee PH, Kang SH, Choi H, Chang M, Roh JH, Yoon SH, Ahn JM, Park DW, Kang SJ, Kim YH, Lee CW, Park SW, Park SJ. Determinants and Prognostic Significance of Periprocedural Myocardial Injury in Patients With Successful Percutaneous Chronic Total Occlusion Interventions. JACC Cardiovasc Interv. 2016 Nov 14;9(21):2220-2228. doi: 10.1016/j.jcin.2016.08.005. PubMed PMID: 27832848.
11: Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF, Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS, Yusa K. A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia. Cell Rep. 2016 Oct 18;17(4):1193-1205. doi: 10.1016/j.celrep.2016.09.079. PubMed PMID: 27760321; PubMed Central PMCID: PMC5081405.
12: Albuquerque AA, Margarido EA, Menardi AC, Scorzoni A Filho, Celotto AC, Rodrigues AJ, Vicente WV, Evora PR. Methylene Blue to Treat Protamine-induced Anaphylaxis Reactions. An Experimental Study in Pigs. Braz J Cardiovasc Surg. 2016 May-Jun;31(3):226-231. doi: 10.5935/1678-9741.20160054. PubMed PMID: 27737405; PubMed Central PMCID: PMC5062710.
13: Song Y, Xie X, Gao Y, Gu G, Wang P. Ultrasound-induced microbubble destruction promotes targeted delivery of adipose-derived stem cells to improve hind-limb ischemia of diabetic mice. Am J Transl Res. 2016 Jun 15;8(6):2585-96. eCollection 2016. PubMed PMID: 27398142; PubMed Central PMCID: PMC4931153.
14: Ye H, Cauley SF, Gagoski B, Bilgic B, Ma D, Jiang Y, Du YP, Griswold MA, Wald LL, Setsompop K. Simultaneous multislice magnetic resonance fingerprinting (SMS-MRF) with direct-spiral slice-GRAPPA (ds-SG) reconstruction. Magn Reson Med. 2017 May;77(5):1966-1974. doi: 10.1002/mrm.26271. Epub 2016 May 25. PubMed PMID: 27220881; PubMed Central PMCID: PMC5123982.
15: de Paula CC, Valadares A, Jurisch M, Piccin E, Augusti R. Paper spray mass spectrometry applied in the monitoring of a chemical system in dynamic chemical equilibrium: the redox process of methylene blue. Rapid Commun Mass Spectrom. 2016 May 15;30(9):1176-80. doi: 10.1002/rcm.7546. PubMed PMID: 27060845.
16: Schmitter S, Moeller S, Wu X, Auerbach EJ, Metzger GJ, Van de Moortele PF, Uğurbil K. Simultaneous multislice imaging in dynamic cardiac MRI at 7T using parallel transmission. Magn Reson Med. 2017 Mar;77(3):1010-1020. doi: 10.1002/mrm.26180. Epub 2016 Mar 7. PubMed PMID: 26949107.
17: Li S, Fu X, Dai Y, Liu C, Wang Y, Li W, Wu W, Gu X, Hao G, Fan W, Miao Q, Jiang Y. [Effects of pretreatment with recombinant human B-type natriuretic peptide on infarct size in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention]. Zhonghua Xin Xue Guan Bing Za Zhi. 2015 Nov;43(11):954-9. Chinese. PubMed PMID: 26888806.
18: Zhang Q, Hu J, Yang ZK, Ding FH, Zhang JS, Du R, Zhu TQ, Shen WF, Kirtane AJ, Zhang RY. Correlates and outcomes related to periprocedural myocardial injury during percutaneous coronary intervention for chronic total occlusion: Results from a prospective, single center PCI registry. Catheter Cardiovasc Interv. 2016 Mar;87 Suppl 1:616-23. doi: 10.1002/ccd.26406. Epub 2016 Feb 10. PubMed PMID: 26864270.
19: Thevis M, Schänzer W. Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun Mass Spectrom. 2016 Mar 15;30(5):635-51. doi: 10.1002/rcm.7470. PubMed PMID: 26842585.
20: Jang WJ, Yang JH, Choi SH, Song YB, Hahn JY, Kim WS, Lee YT, Kim BS, Gwon HC. Association of periprocedural myocardial infarction with long-term survival in patients treated with coronary revascularization therapy of chronic total occlusion. Catheter Cardiovasc Interv. 2016 May;87(6):1042-9. doi: 10.1002/ccd.26286. Epub 2015 Nov 3. PubMed PMID: 26525460.
