R 50595

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461067

CAS#: 104860-61-9

Description: R 50595 is a selective non-competitive antagonist of cisapride.


Chemical Structure

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R 50595
CAS# 104860-61-9

Theoretical Analysis

MedKoo Cat#: 461067
Name: R 50595
CAS#: 104860-61-9
Chemical Formula: C30H35Cl2F2N3O3
Exact Mass: 593.2024
Molecular Weight: 594.52
Elemental Analysis: C, 60.61; H, 5.93; Cl, 11.93; F, 6.39; N, 7.07; O, 8.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: R 50595; R-50595; R50595;

IUPAC/Chemical Name: 4-amino-N-((3S,4R)-1-(4,4-bis(4-fluorophenyl)butyl)-3-methoxypiperidin-4-yl)-5-chloro-2-methoxybenzamide hydrochloride

InChi Key: ODGIHIUVACVQTA-KIIRSEDSSA-N

InChi Code: InChI=1S/C30H34ClF2N3O3.ClH/c1-38-28-17-26(34)25(31)16-24(28)30(37)35-27-13-15-36(18-29(27)39-2)14-3-4-23(19-5-9-21(32)10-6-19)20-7-11-22(33)12-8-20;/h5-12,16-17,23,27,29H,3-4,13-15,18,34H2,1-2H3,(H,35,37);1H/t27-,29+;/m1./s1

SMILES Code: O=C(N[C@H]1[C@@H](OC)CN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(Cl)=C(N)C=C4OC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 594.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Van den Brink HW, Schuurkes JA, Van Nueten JM, Van Rossum JM. R 50 595, a selective non-competitive antagonist of cisapride, BRL 24924 and 5-hydroxytryptamine on the guinea-pig ileum. Eur J Pharmacol. 1990 May 31;181(1-2):119-25. PubMed PMID: 2387319.

2: Meulemans AL, Schuurkes JA. Is the action of cisapride on the guinea-pig ileum mediated via 5-HT4 receptors? Eur J Pharmacol. 1992 Feb 25;212(1):51-9. PubMed PMID: 1555639.