NTE-122
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MedKoo CAT#: 563381

CAS#: 166967-84-6

Description: NTE-122 is a potent, selective and competitive inhibitor of Acyl-CoA:cholesterol acyltransferase (ACAT).


Price and Availability

Size Price Shipping out time Quantity
5mg USD 340 2 Weeks
10mg USD 560 2 Weeks
25mg USD 1015 2 Weeks
50mg USD 1665 2 Weeks
100mg USD 2665 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NTE-122, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563381
Name: NTE-122
CAS#: 166967-84-6
Chemical Formula: C38H58N6O2
Exact Mass: 630.4621
Molecular Weight: 630.92
Elemental Analysis: C, 72.34; H, 9.27; N, 13.32; O, 5.07


Synonym: NTE-122; NTE 122; NTE122;

IUPAC/Chemical Name: trans-1,4-Bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane

InChi Key: SIHFCVXQGXGQQO-WXUXXXNLSA-N

InChi Code: InChI=1S/C38H58N6O2/c1-41(2)33-23-19-31(20-24-33)39-37(45)43(35-11-7-5-8-12-35)27-29-15-17-30(18-16-29)28-44(36-13-9-6-10-14-36)38(46)40-32-21-25-34(26-22-32)42(3)4/h19-26,29-30,35-36H,5-18,27-28H2,1-4H3,(H,39,45)(H,40,46)/t29-,30-

SMILES Code: O=C(NC1=CC=C(N(C)C)C=C1)N(C[C@H]2CC[C@H](CN(C3CCCCC3)C(NC4=CC=C(N(C)C)C=C4)=O)CC2)C5CCCCC5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Azuma Y, Date K, Ohno K, Matsushiro S, Nobuhara Y, Yamada T. NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3. PubMed PMID: 11430463.

2: Ohgami N, Kuniyasu A, Furukawa K, Miyazaki A, Hakamata H, Horiuchi S, Nakayama H. Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Biochem Biophys Res Commun. 2000 Oct 22;277(2):417-22. PubMed PMID: 11032738.

3: Nakayama H, Ohgami N, Kuniyasu A, Miyazaki A, Hakamata H, Horiuchi S. [Glibenclamide inhibits cholesterol metabolism in macrophage]. Nihon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:150P-153P. Japanese. PubMed PMID: 10629872.

4: Azuma Y, Seto J, Ohno K, Mikami H, Yamada T, Yamasaki M, Chiba M, Nobuhara Y. Effects of NTE-122, an acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and lipid secretion from CaCo-2 cells, and cholesterol absorption in rats. Jpn J Pharmacol. 1999 May;80(1):81-4. PubMed PMID: 10446760.

5: Azuma Y, Kawasaki T, Ikemoto K, Ohno K, Yamada T, Yamasaki M, Nobuhara Y. Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. Jpn J Pharmacol. 1999 Feb;79(2):159-67. PubMed PMID: 10202851.

6: Azuma Y, Kawasaki T, Ohno K, Seto J, Yamada T, Yamasaki M, Nobuhara Y. Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. Jpn J Pharmacol. 1999 Feb;79(2):151-8. PubMed PMID: 10202850.

7: Azuma Y, Kawasaki T, Ikemoto K, Obata K, Ohno K, Sajiki N, Yamada T, Yamasaki M, Nobuhara Y. Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol. 1998 Nov;78(3):355-64. PubMed PMID: 9869270.

8: Kawasaki T, Miyazaki A, Hakamata H, Matsuda H, Horiuchi S. Biochemical evidence for oligomerization of rat adrenal acyl-coenzyme A:cholesterol acyltransferase. Biochem Biophys Res Commun. 1998 Mar 17;244(2):347-52. PubMed PMID: 9514926.