Papaveraldine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558453

CAS#: 522-57-6

Description: Papaveraldine is a degradation product of papaverine and known benzylisoquinoline alkaloid.

Chemical Structure

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Papaveraldine
CAS# 522-57-6
Instruction

Theoretical Analysis

MedKoo Cat#: 558453
Name: Papaveraldine
CAS#: 522-57-6
Chemical Formula: C20H19NO5
Exact Mass: 353.13
Molecular Weight: 353.370
Elemental Analysis: C, 67.98; H, 5.42; N, 3.96; O, 22.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Papaveraldine; Papaveraldine; Xanthaline;

IUPAC/Chemical Name: (6,7-Dimethoxy-1-isoquinolyl) (3,4-dimethoxyphenyl) ketone

InChi Key: QJTBIAMBPGGIGI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO5/c1-23-15-6-5-13(10-16(15)24-2)20(22)19-14-11-18(26-4)17(25-3)9-12(14)7-8-21-19/h5-11H,1-4H3

SMILES Code: O=C(C1=NC=CC2=C1C=C(OC)C(OC)=C2)C3=CC=C(OC)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Piotrowska K, Hermann TW, Augustyniak W. Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions. Acta Pol Pharm. 2002 Sep-Oct;59(5):359-64. PubMed PMID: 12602797.

2: Colautti A, Fontani F, Maurich V. HPLC determination of papaveraldine and papaverinol in papaverine injection. J Pharm Biomed Anal. 1987;5(5):493-9. PubMed PMID: 16867493.

3: MACHOVICOVA F, PARRAK V. [Paper chromatographic separation of papaverine, papaverinol & papaveraldine]. Pharmazie. 1959 Jan;14(1):10-2. German. PubMed PMID: 13657671.

4: KREPINSKY J. [Spectrophotometric and colorimetric determination of papverinol and papaveraldine in papaverine]. Cesk Farm. 1962 May 5;11:205-10. Czech. PubMed PMID: 14459579.

5: MERCIER F, MERCIER J, SESTIER MR. [Experimental spasmolytic action of papaverinol and papaveraldine, secondary alkaloids prepared during papaverine synthesis]. C R Seances Soc Biol Fil. 1951 Mar;145(5-6):408-10. Undetermined Language. PubMed PMID: 14849079.

6: El Sayed KA. Microbial transformation of papaveraldine. Phytochemistry. 2000 Mar;53(6):675-8. PubMed PMID: 10746880.

7: Postaire E, Oulare B, Pradeau D, Hamon M. [Simultaneous assay of papaverine and papaveraldine. Applications to the control of pharmaceutical preparations and kinetic study of oxidation reactions]. Ann Pharm Fr. 1985;43(6):547-56. French. PubMed PMID: 3838030.

8: Maurich V, Moneghini M. [HPLC separation of papaverine hydrochloride and its degradation products papaveraldine and papaverinol. Quantitative determination in vials and granules]. Boll Chim Farm. 1983 Jul;122(7):322-9. Italian. PubMed PMID: 6651970.

9: Habashy GM, Farid NA. Thin-layer chromatographic method for separation and determination of papaverine and its oxidation products. Talanta. 1973 Jul;20(7):699-702. PubMed PMID: 18961335.

10: Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon P. Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. J Pharm Pharmacol. 1992 Apr;44(4):337-43. PubMed PMID: 1355547.

11: Piotrowska K, Hermann TW, Augustyniak W. Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products. J Pharm Biomed Anal. 2006 Jun 16;41(4):1391-5. Epub 2006 Mar 31. PubMed PMID: 16580169.

12: Pingaew R, Prachayasittikul S, Ruchirawat S. Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds. Molecules. 2010 Feb 23;15(2):988-96. doi: 10.3390/molecules15020988. PubMed PMID: 20335957.

13: Girreser U, Hermann TW, Piotrowska K. Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions. Arch Pharm (Weinheim). 2003 Sep;336(9):401-5. PubMed PMID: 14528487.

14: Pohloudek-Fabini R, Gundermann P. [Contribution to the stability of papaverine. Part 2: Quantitative determination of papaverine in the presence of degradation products (author's transl)]. Pharmazie. 1979;34(2):75-6. German. PubMed PMID: 441109.