NeuroSensor 521
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MedKoo CAT#: 563377

CAS#: 1428730-05-5

Description: NeuroSensor 521 is a fluorescent turn-on sensor. It acts by binding catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 320 2 Weeks
25mg USD 840 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

NeuroSensor 521, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563377
Name: NeuroSensor 521
CAS#: 1428730-05-5
Chemical Formula: C21H21NO4
Exact Mass: 351.1471
Molecular Weight: 351.4
Elemental Analysis: C, 71.78; H, 6.02; N, 3.99; O, 18.21


Synonym: NeuroSensor 521; NeuroSensor-521; NeuroSensor521;

IUPAC/Chemical Name: 7-Diethylamino-3-formyl-4-(4-methoxyphenyl)coumarin

InChi Key: GOYKALWTTJFRLM-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21NO4/c1-4-22(5-2)15-8-11-17-19(12-15)26-21(24)18(13-23)20(17)14-6-9-16(25-3)10-7-14/h6-13H,4-5H2,1-3H3

SMILES Code: O=C1OC2=C(C=CC(N(CC)CC)=C2)C(C3=CC=C(OC)C=C3)=C1C=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Hettie KS, Glass TE. Coumarin-3-aldehyde as a scaffold for the design of tunable PET-modulated fluorescent sensors for neurotransmitters. Chemistry. 2014 Dec 22;20(52):17488-99. doi: 10.1002/chem.201403128. Epub 2014 Oct 24. PubMed PMID: 25346467.

2: Hettie KS, Liu X, Gillis KD, Glass TE. Selective catecholamine recognition with NeuroSensor 521: a fluorescent sensor for the visualization of norepinephrine in fixed and live cells. ACS Chem Neurosci. 2013 Jun 19;4(6):918-23. doi: 10.1021/cn300227m. Epub 2013 Mar 25. PubMed PMID: 23527575; PubMed Central PMCID: PMC3708293.