AEM1 | CAS#1030123-90-0 | NRF2 inhibitor

AEM1
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563367

CAS#: 1030123-90-0

Description: AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. It acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.

Chemical Structure

AEM1

CAS# 1030123-90-0

Instruction

Theoretical Analysis

MedKoo Cat#: 563367
Name: AEM1
CAS#: 1030123-90-0
Chemical Formula: C20H14FN3O2S
Exact Mass: 379.08
Molecular Weight: 379.400
Elemental Analysis: C, 63.31; H, 3.72; F, 5.01; N, 11.08; O, 8.43; S, 8.45

Price and Availability

Size	Price	Availability
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1350	2 Weeks
500mg	USD 2450	2 Weeks
1g	USD 3450	2 Weeks
2g	USD 5850	2 Weeks
5g	USD 7950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: AEM1; AEM-1; AEM 1;

IUPAC/Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

InChi Key: QGYLTGSHWIGJJD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)

SMILES Code: FC1=CC=C(C2=CSC3=NC=NC(NCC4=CC=C(OCO5)C5=C4)=C32)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 379.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Magurran AE, Deacon AE, Moyes F, Shimadzu H, Dornelas M, Phillip DAT, Ramnarine IW. Divergent biodiversity change within ecosystems. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1843-1847. doi: 10.1073/pnas.1712594115. Epub 2018 Feb 12. PubMed PMID: 29440416; PubMed Central PMCID: PMC5828582.

2: Magurran AE. The important challenge of quantifying tropical diversity. BMC Biol. 2017 Mar 7;15(1):14. doi: 10.1186/s12915-017-0358-6. PubMed PMID: 28264673; PubMed Central PMCID: PMC5339971.

3: Magurran AE. ECOLOGY. How ecosystems change. Science. 2016 Jan 29;351(6272):448-9. doi: 10.1126/science.aad6758. PubMed PMID: 26823412.

4: Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10(10):2193-8. doi: 10.1021/acschembio.5b00448. Epub 2015 Aug 17. PubMed PMID: 26270491.

5: Hoffmann G, Breitenbücher F, Schuler M, Ehrenhofer-Murray AE. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289(8):5208-16. doi: 10.1074/jbc.M113.487736. Epub 2013 Dec 30. PubMed PMID: 24379401; PubMed Central PMCID: PMC3931077.

6: Magurran AE. Open questions: some unresolved issues in biodiversity. BMC Biol. 2013 Dec 6;11:118. doi: 10.1186/1741-7007-11-118. PubMed PMID: 24314168; PubMed Central PMCID: PMC4029625.

7: Magurran AE, Henderson PA. How selection structures species abundance distributions. Proc Biol Sci. 2012 Sep 22;279(1743):3722-6. doi: 10.1098/rspb.2012.1379. Epub 2012 Jul 11. PubMed PMID: 22787020; PubMed Central PMCID: PMC3415926.

8: Magurran AE, Khachonpisitsak S, Ahmad AB. Biological diversity of fish communities: pattern and process. J Fish Biol. 2011 Dec;79(6):1393-412. doi: 10.1111/j.1095-8649.2011.03091.x. Epub 2011 Oct 14. Review. PubMed PMID: 22136233.

9: Magurran AE. Q&A: What is biodiversity? BMC Biol. 2010 Dec 15;8:145. doi: 10.1186/1741-7007-8-145. PubMed PMID: 21159210; PubMed Central PMCID: PMC3002324.

10: Magurran AE, Henderson PA. Temporal turnover and the maintenance of diversity in ecological assemblages. Philos Trans R Soc Lond B Biol Sci. 2010 Nov 27;365(1558):3611-20. doi: 10.1098/rstb.2010.0285. PubMed PMID: 20980310; PubMed Central PMCID: PMC2982009.

11: Magurran AE, Dornelas M. Biological diversity in a changing world. Philos Trans R Soc Lond B Biol Sci. 2010 Nov 27;365(1558):3593-7. doi: 10.1098/rstb.2010.0296. PubMed PMID: 20980308; PubMed Central PMCID: PMC2982013.

12: Magurran AE, Baillie SR, Buckland ST, Dick JM, Elston DA, Scott EM, Smith RI, Somerfield PJ, Watt AD. Long-term datasets in biodiversity research and monitoring: assessing change in ecological communities through time. Trends Ecol Evol. 2010 Oct;25(10):574-82. doi: 10.1016/j.tree.2010.06.016. Epub 2010 Jul 23. Review. PubMed PMID: 20656371.

13: Magurran A. Evolution of biological diversity. Curr Biol. 2010 Jul 13;20(13):R545-6. PubMed PMID: 20641176.

14: Magurran AE. Ecology. Threats to freshwater fish. Science. 2009 Sep 4;325(5945):1215-6. doi: 10.1126/science.1177215. PubMed PMID: 19729647.

15: Magurran AE. Species abundance distributions over time. Ecol Lett. 2007 May;10(5):347-54. PubMed PMID: 17498133.

16: Debi BR, Chhun T, Taketa S, Tsurumi S, Xia K, Miyao A, Hirochika H, Ichii M. Defects in root development and gravity response in the aem1 mutant of rice are associated with reduced auxin efflux. J Plant Physiol. 2005 Jun;162(6):678-85. PubMed PMID: 16008090.

17: Magurran AE, Henderson PA. Explaining the excess of rare species in natural species abundance distributions. Nature. 2003 Apr 17;422(6933):714-6. PubMed PMID: 12700760.

18: Magurran AE. Sexual conflict and evolution in Trinidadian guppies. Genetica. 2001;112-113:463-74. Review. PubMed PMID: 11838783.

19: Lee IS, ElSohly HN, Hufford CD. Microbial metabolism studies of the antimalarial drug arteether. Pharm Res. 1990 Feb;7(2):199-203. PubMed PMID: 2308900.

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