WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592364
CAS#: 20853-58-1
Description: Cauloside C, also known as Hederoside D2, is a triterpenoid saponin that induces potassium release and hemolysis in mouse erythrocytes in a pH-dependent manner. Hederoside D2 is cytotoxic to N1E-115 neuroblastoma cells at low pH. It induces proliferation of human embryonic fibroblasts in acidic medium, an effect that can be blocked by the calcium channel blockers verapamil, diltiazem, and nitrendipine.
MedKoo Cat#: 592364
Name: Cauloside C
CAS#: 20853-58-1
Chemical Formula: C41H66O13
Exact Mass: 766.4503
Molecular Weight: 766.97
Elemental Analysis: C, 64.21; H, 8.67; O, 27.12
Synonym: Cauloside C; Cauloside C; Fatsiaside D1; Hederoside D2
IUPAC/Chemical Name: 3-((2-0-beta-D-Glucopyranosyl-alpha-L-arabinopyranosyl)oxy)-23-hydroxyolean-12-en-28-oic acid
InChi Key: RROGHRHLBLVQSG-UUWFFIQNSA-N
InChi Code: InChI=1S/C41H66O13/c1-36(2)13-15-41(35(49)50)16-14-39(5)21(22(41)17-36)7-8-26-37(3)11-10-27(38(4,20-43)25(37)9-12-40(26,39)6)53-34-32(28(45)23(44)19-51-34)54-33-31(48)30(47)29(46)24(18-42)52-33/h7,22-34,42-48H,8-20H2,1-6H3,(H,49,50)/t22-,23-,24+,25+,26+,27-,28-,29+,30-,31+,32+,33-,34-,37-,38-,39+,40+,41-/m0/s1
SMILES Code: CC1(CC[C@]2(C(O)=O)CC[C@@]3(C([C@@H]2C1)=CC[C@@H]4[C@]5(CC[C@@H]([C@@](CO)([C@@H]5CC[C@@]34C)C)O[C@@H]6OC[C@@H]([C@@H]([C@H]6O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)O)C)C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 766.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Strigina LI, Isakov VV. [The structure of sulfated cauloside C]. Bioorg Khim. 2000 May;26(5):387-91. Russian. PubMed PMID: 10900510.
2: Aminin DL, Agafonova IG, Gnedoi SN, Strigina LI, Anisimov MM. The effect of pH on biological activity of plant cytotoxin cauloside C. Comp Biochem Physiol A Mol Integr Physiol. 1999 Jan;122(1):45-51. PubMed PMID: 10216931.
3: Likhatskaya GN, Aminin DL, Agafonova IG, Gnedoi SN, Shentsova EB, Strigina LI, Anisimov MM. The pH-dependent channels formed by cauloside C. Adv Exp Med Biol. 1996;404:239-49. PubMed PMID: 8957300.
4: Prokof'eva NG, Likhatskaia GN, Aminin DL, Gafurov IuM, Sasunkevich VA, Strigina LI, Anisimov MM. [The mechanism of the interaction of the pH-dependent cytostatic cauloside C with the membranes of tumor cells and liposomes]. Izv Akad Nauk SSSR Biol. 1990 May-Jun;(3):338-42. Russian. PubMed PMID: 2401767.
