WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563363

CAS#: 192718-06-2

Description: C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells.

Chemical Structure

CAS# 192718-06-2

Theoretical Analysis

MedKoo Cat#: 563363
Name: C527
CAS#: 192718-06-2
Chemical Formula: C17H8FNO3
Exact Mass: 293.0488
Molecular Weight: 293.25
Elemental Analysis: C, 69.63; H, 2.75; F, 6.48; N, 4.78; O, 16.37

Price and Availability

Size Price Availability Quantity
5.0mg USD 270.0 2 Weeks
25.0mg USD 650.0 2 Weeks
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Synonym: C527; C-527; C 527;

IUPAC/Chemical Name: 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione


InChi Code: InChI=1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H

SMILES Code: O=C(C1=C2OC(C3=CC=C(F)C=C3)=N1)C4=C(C=CC=C4)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 293.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Goncalves JM, Cordeiro MMR, Rivero ERC. The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells. Curr Stem Cell Res Ther. 2017;12(5):416-422. doi: 10.2174/1574888X12666170315104013. Review. PubMed PMID: 28302046.

2: Ngo AT, Thierheimer ML, Babur Ö, Rocheleau AD, Huang T, Pang J, Rigg RA, Mitrugno A, Theodorescu D, Burchard J, Nan X, Demir E, McCarty OJ, Aslan JE. Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C527-C536. doi: 10.1152/ajpcell.00274.2016. Epub 2017 Feb 1. PubMed PMID: 28148498; PubMed Central PMCID: PMC5407014.

3: Ostrom RS. A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention". Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C527-8. doi: 10.1152/ajpcell.00020.2014. Epub 2014 Jan 22. PubMed PMID: 24452379.

4: Cuddapah VA, Habela CW, Watkins S, Moore LS, Barclay TT, Sontheimer H. Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C527-38. doi: 10.1152/ajpcell.00248.2011. Epub 2011 Nov 2. PubMed PMID: 22049206; PubMed Central PMCID: PMC3287156.

5: Capolicchio JP. Laparoscopic extravesical ureteral reimplantation: technique. Adv Urol. 2008:567980. doi: 10.1155/2008/567980. PubMed PMID: 18725984; PubMed Central PMCID: PMC2517660.

6: Chen YC, Tou JC, Jaczynski J. Amino acid, fatty acid, and mineral profiles of materials recovered from rainbow trout (Oncorhynchus mykiss) processing by-products using isoelectric solubilization/precipitation. J Food Sci. 2007 Nov;72(9):C527-35. PubMed PMID: 18034715.

7: Kockskämper J, Ahmmed GU, Zima AV, Sheehan KA, Glitsch HG, Blatter LA. Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Am J Physiol Cell Physiol. 2004 Aug;287(2):C527-38. Epub 2004 Apr 14. PubMed PMID: 15084477.

8: Decaens C, Cassio D. Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells. Am J Physiol Cell Physiol. 2001 Mar;280(3):C527-39. PubMed PMID: 11171572.

9: Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol. 1998 Aug;275(2 Pt 1):C527-34. PubMed PMID: 9688607.

10: Unguez GA, Roy RR, Pierotti DJ, Bodine-Fowler S, Edgerton VR. Further evidence of incomplete neural control of muscle properties in cat tibialis anterior motor units. Am J Physiol. 1995 Feb;268(2 Pt 1):C527-34. PubMed PMID: 7864092.

11: Shetty M, Ismail-Beigi N, Loeb JN, Ismail-Beigi F. Induction of GLUT1 mRNA in response to inhibition of oxidative phosphorylation. Am J Physiol. 1993 Nov;265(5 Pt 1):C1224-9. PubMed PMID: 7694490.

12: Vogalis F, Lang RJ, Bywater RA, Taylor GS. Voltage-gated ionic currents in smooth muscle cells of guinea pig proximal colon. Am J Physiol. 1993 Mar;264(3 Pt 1):C527-36. PubMed PMID: 8384782.

13: Shetty M, Loeb JN, Ismail-Beigi F. Enhancement of glucose transport in response to inhibition of oxidative metabolism: pre- and posttranslational mechanisms. Am J Physiol. 1992 Feb;262(2 Pt 1):C527-32. PubMed PMID: 1539639.

14: Restrepo D, Cronise BL, Snyder RB, Spinelli LJ, Knauf PA. Kinetics of DIDS inhibition of HL-60 cell anion exchange rules out ping-pong model with slippage. Am J Physiol. 1991 Mar;260(3 Pt 1):C535-44. PubMed PMID: 1848401.

15: Serrano-Castro A, de Abajo FJ, Sánchez-García P. Li+ as a secretagogue agent. Am J Physiol. 1990 Sep;259(3 Pt 1):C527-9. PubMed PMID: 2169199.

16: Ahn J, Chang EB, Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov;249(5 Pt 1):C527-30. PubMed PMID: 3864381.

17: Pace CS, Goldsmith KT. Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity. Am J Physiol. 1985 May;248(5 Pt 1):C527-34. PubMed PMID: 3158214.


5.0mg / USD 270.0