WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598064

CAS#: 1050-28-8

Description: Tyrosyltyrosine is a peptide.

Chemical Structure

CAS# 1050-28-8

Theoretical Analysis

MedKoo Cat#: 598064
Name: Tyrosyltyrosine
CAS#: 1050-28-8
Chemical Formula: C18H20N2O5
Exact Mass: 344.1372
Molecular Weight: 344.36
Elemental Analysis: C, 62.78; H, 5.85; N, 8.13; O, 23.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Tyrosyltyrosine; Tyrosyl tyrosine; Tyr-tyr; Peptide tyrosine-tyrosine;

IUPAC/Chemical Name: L-tyrosyl-L-tyrosine


InChi Code: InChI=1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1

SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](CC2=CC=C(O)C=C2)N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 344.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Chowdhury EA, Richardson JD, Tsintzas K, Thompson D, Betts JA. Carbohydrate-rich breakfast attenuates glycaemic, insulinaemic and ghrelin response to ad libitum lunch relative to morning fasting in lean adults. Br J Nutr. 2015 Jul 14;114(1):98-107. doi: 10.1017/S0007114515001506. Epub 2015 May 25. PubMed PMID: 26004166; PubMed Central PMCID: PMC4530602.

2: Chowdhury EA, Richardson JD, Tsintzas K, Thompson D, Betts JA. Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults. Int J Obes (Lond). 2016 Feb;40(2):305-11. doi: 10.1038/ijo.2015.154. Epub 2015 Aug 17. PubMed PMID: 26278005; PubMed Central PMCID: PMC4753359.

3: Madelmont JC, Meyniel G. [Identification in bovine thyroglobulin of an iodinated dipeptide, tetraiodinated tyrosyltyrosine]. C R Acad Sci Hebd Seances Acad Sci D. 1973 Feb 19;276(8):1357-9. French. PubMed PMID: 4196304.

4: Yakabi K, Yamaguchi N, Hosomi E. Appetite-regulating gut peptides and functional dyspepsia. Nihon Shokakibyo Gakkai Zasshi. 2016;113(10):1672-1681. Japanese. PubMed PMID: 27725457.

5: Pasricha PJ. Hunger games: is your stomach making you fat? Gastroenterology. 2015 Mar;148(3):491-3. doi: 10.1053/j.gastro.2015.01.010. Epub 2015 Jan 19. PubMed PMID: 25613313.

6: Sim AY, Wallman KE, Fairchild TJ, Guelfi KJ. Effects of High-Intensity Intermittent Exercise Training on Appetite Regulation. Med Sci Sports Exerc. 2015 Nov;47(11):2441-9. doi: 10.1249/MSS.0000000000000687. PubMed PMID: 25899101.

7: Chungchunlam SM, Henare SJ, Ganesh S, Moughan PJ. Dietary whey protein influences plasma satiety-related hormones and plasma amino acids in normal-weight adult women. Eur J Clin Nutr. 2015 Feb;69(2):179-86. doi: 10.1038/ejcn.2014.266. Epub 2015 Jan 7. PubMed PMID: 25563737.

8: Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Burton D, O'Neill J, Eckert D, Zinsmeister AR. Quantitative gastrointestinal and psychological traits associated with obesity and response to weight-loss therapy. Gastroenterology. 2015 Mar;148(3):537-546.e4. doi: 10.1053/j.gastro.2014.11.020. Epub 2014 Dec 6. PubMed PMID: 25486131; PubMed Central PMCID: PMC4339485.

9: Bottin JH, Swann JR, Cropp E, Chambers ES, Ford HE, Ghatei MA, Frost GS. Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial. Br J Nutr. 2016 Jul;116(2):360-74. doi: 10.1017/S0007114516001872. Epub 2016 May 20. PubMed PMID: 27198187; PubMed Central PMCID: PMC4910676.

10: Lin T, Li S, Xu H, Zhou H, Feng R, Liu W, Sun Y, Ma J. Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. Hum Reprod. 2015 Nov;30(11):2639-44. doi: 10.1093/humrep/dev231. Epub 2015 Sep 15. PubMed PMID: 26373789.

11: Chu W, Li X, Gao N, Deng Y, Yin D, Li D, Chu T. Peptide bonds affect the formation of haloacetamides, an emerging class of N-DBPs in drinking water: free amino acids versus oligopeptides. Sci Rep. 2015 Sep 23;5:14412. doi: 10.1038/srep14412. PubMed PMID: 26394759; PubMed Central PMCID: PMC4585778.

12: Ma Y, Liu J, Shi H, Yu LL. Isolation and characterization of anti-inflammatory peptides derived from whey protein. J Dairy Sci. 2016 Sep;99(9):6902-6912. doi: 10.3168/jds.2016-11186. Epub 2016 Jul 7. PubMed PMID: 27394940.

13: Mitsuhashi J, Nakayama T, Narai-Kanayama A. Mechanism of papain-catalyzed synthesis of oligo-tyrosine peptides. Enzyme Microb Technol. 2015 Jul-Aug;75-76:10-7. doi: 10.1016/j.enzmictec.2015.03.007. Epub 2015 Apr 28. PubMed PMID: 26047910.

14: Heden TD, Liu Y, Kanaley JA. Impact of Exercise Timing on Appetite Regulation in Individuals with Type 2 Diabetes. Med Sci Sports Exerc. 2016 Feb;48(2):182-9. doi: 10.1249/MSS.0000000000000755. PubMed PMID: 26285022; PubMed Central PMCID: PMC4715580.

15: Till H, Schlichting N, Oberbach A. Tumor-associated energy homeostasis: hepatoblastoma and neuroblastoma affect glucose and lipid metabolism as well as ghrelin, GLP-1, and PYY in nude rats. Eur J Pediatr Surg. 2015 Feb;25(1):128-31. doi: 10.1055/s-0034-1386640. Epub 2014 Aug 11. PubMed PMID: 25111274.

16: Zapata RC, Salehi R, Ambrose DJ, Chelikani PK. Effects of prepartum fat supplementation on plasma concentrations of glucagon-like peptide-1, peptide YY, adropin, insulin, and leptin in periparturient dairy cows. J Dairy Sci. 2015 Oct;98(10):6876-85. doi: 10.3168/jds.2014-9283. Epub 2015 Jul 22. PubMed PMID: 26210271.

17: Michelot J, Meyniel G. [Methods for identification of tetraiodinated tyrosyltyrosine in rabbit thyroid hydrolysates]. C R Seances Soc Biol Fil. 1970;164(12):2497-503. French. PubMed PMID: 4258351.

18: Astbury NM, Taylor MA, French SJ, Macdonald IA. Snacks containing whey protein and polydextrose induce a sustained reduction in daily energy intake over 2 wk under free-living conditions. Am J Clin Nutr. 2014 May;99(5):1131-40. doi: 10.3945/ajcn.113.075978. Epub 2014 Mar 26. Erratum in: Am J Clin Nutr. 2014 Nov;100(5):1405. PubMed PMID: 24670946.

19: Meyer-Gerspach AC, Wölnerhanssen B, Beglinger B, Nessenius F, Napitupulu M, Schulte FH, Steinert RE, Beglinger C. Gastric and intestinal satiation in obese and normal weight healthy people. Physiol Behav. 2014 Apr 22;129:265-71. doi: 10.1016/j.physbeh.2014.02.043. Epub 2014 Feb 28. PubMed PMID: 24582673.

20: Li H, Wang Z, Dong L, Jiang J, Xu X, Zhou L, Wan Y. Peptide tyrosine-tyrosine combined with its receptors exhibits an anti-cancer potential in pancreatic cancer MiaPaCa-2 cell. Chin Med J (Engl). 2014;127(24):4235-42. PubMed PMID: 25533827.