PYX 1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598060

CAS#: 140842-17-7

Description: PYX 1 is a potent orexigenic peptide.


Chemical Structure

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PYX 1
CAS# 140842-17-7

Theoretical Analysis

MedKoo Cat#: 598060
Name: PYX 1
CAS#: 140842-17-7
Chemical Formula: C70H105Cl2N19O16
Exact Mass: 1537.7364
Molecular Weight: 1539.62
Elemental Analysis: C, 54.61; H, 6.87; Cl, 4.61; N, 17.29; O, 16.63

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PYX 1; PYX-1; PYX1; Ac-Tyr-3-(Cl2Bzl)-ile-asn-leu-ile-D-thr-arg-gln-arg-tyr-NH2;

IUPAC/Chemical Name: (S)-2-((2S,5R,8S,11S,14S,17S,20S)-14-(2-amino-2-oxoethyl)-8,17-di((S)-sec-butyl)-20-(3-(2,6-dichlorobenzyl)-4-hydroxybenzyl)-2-(3-guanidinopropyl)-5-((S)-1-hydroxyethyl)-11-isobutyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatricosanamido)-N1-((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)pentanediamide

InChi Key: LNUMCIVYAIEPPL-XFBIFGDYSA-N

InChi Code: InChI=1S/C70H105Cl2N19O16/c1-9-35(5)56(89-65(104)51(82-38(8)93)31-40-20-24-53(95)41(29-40)32-43-44(71)14-11-15-45(43)72)66(105)88-52(33-55(74)97)63(102)87-50(28-34(3)4)64(103)90-57(36(6)10-2)67(106)91-58(37(7)92)68(107)85-47(17-13-27-81-70(78)79)60(99)84-48(23-25-54(73)96)62(101)83-46(16-12-26-80-69(76)77)61(100)86-49(59(75)98)30-39-18-21-42(94)22-19-39/h11,14-15,18-22,24,29,34-37,46-52,56-58,92,94-95H,9-10,12-13,16-17,23,25-28,30-33H2,1-8H3,(H2,73,96)(H2,74,97)(H2,75,98)(H,82,93)(H,83,101)(H,84,99)(H,85,107)(H,86,100)(H,87,102)(H,88,105)(H,89,104)(H,90,103)(H,91,106)(H4,76,77,80)(H4,78,79,81)/t35-,36-,37-,46-,47-,48-,49-,50-,51-,52-,56-,57-,58+/m0/s1

SMILES Code: CC[C@@H]([C@H](NC([C@@H](NC(C)=O)Cc1cc(Cc2c(Cl)cccc2Cl)c(O)cc1)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)Cc3ccc(O)cc3)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)[C@@H](O)C)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(N)=O)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1539.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227-34. PubMed PMID: 7800854.

2: Oellerich WF, Malik KU. Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1993 Sep;266(3):1321-9. PubMed PMID: 8371140.

3: Ault DT, Radeff JM, Werling LL. Modulation of [3H]Dopamine release from rat nucleus accumbens by neuropeptide Y may involve a sigma1-like receptor. J Pharmacol Exp Ther. 1998 Feb;284(2):553-60. PubMed PMID: 9454797.