PYX 2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598057

CAS#: 146999-93-1

Description: PYX 2 is a neuropeptide Y receptor antagonist.


Chemical Structure

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PYX 2
CAS# 146999-93-1

Theoretical Analysis

MedKoo Cat#: 598057
Name: PYX 2
CAS#: 146999-93-1
Chemical Formula: C77H108Cl4N18O17
Exact Mass: 1696.6894
Molecular Weight: 1699.62
Elemental Analysis: C, 54.41; H, 6.41; Cl, 8.34; N, 14.83; O, 16.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PYX 2; PYX-2; PYX2;

IUPAC/Chemical Name: (2S,5S,8S,11S,14R,17S,20S,23S,26S,29S)-23-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-17,26-di((S)-sec-butyl)-2,29-bis(3-(2,6-dichlorobenzyl)-4-hydroxybenzyl)-5,11-bis(3-guanidinopropyl)-14-((S)-1-hydroxyethyl)-20-isobutyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanoic acid

InChi Key: ZAQGGXGNZHMCAL-JPXADNNBSA-N

InChi Code: InChI=1S/C77H108Cl4N18O17/c1-9-38(5)63(97-71(111)56(90-41(8)101)32-42-21-24-59(102)44(30-42)34-46-48(78)15-11-16-49(46)79)72(112)95-57(36-62(83)105)69(109)94-55(29-37(3)4)70(110)98-64(39(6)10-2)73(113)99-65(40(7)100)74(114)93-53(20-14-28-89-77(86)87)66(106)92-54(23-26-61(82)104)68(108)91-52(19-13-27-88-76(84)85)67(107)96-58(75(115)116)33-43-22-25-60(103)45(31-43)35-47-50(80)17-12-18-51(47)81/h11-12,15-18,21-22,24-25,30-31,37-40,52-58,63-65,100,102-103H,9-10,13-14,19-20,23,26-29,32-36H2,1-8H3,(H2,82,104)(H2,83,105)(H,90,101)(H,91,108)(H,92,106)(H,93,114)(H,94,109)(H,95,112)(H,96,107)(H,97,111)(H,98,110)(H,99,113)(H,115,116)(H4,84,85,88)(H4,86,87,89)/t38-,39-,40-,52-,53-,54-,55-,56-,57-,58-,63-,64-,65+/m0/s1

SMILES Code: OC1=CC=C(C=C1CC2=C(Cl)C=CC=C2Cl)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]([C@@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C(CC4=C(Cl)C=CC=C4Cl)=C3)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1699.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Palea S, Corsi M, Rimland JM, Trist DG, Ratti E. Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. Br J Pharmacol. 1995 Nov;116(5):2401-6. PubMed PMID: 8581275; PubMed Central PMCID: PMC1909051.

2: Leibowitz SF, Xuereb M, Kim T. Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2. Neuroreport. 1992 Nov;3(11):1023-6. PubMed PMID: 1482761.

3: Beck B, Stricker-Krongrad A, Musse N, Nicolas JP, Burlet C. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci Lett. 1994 Nov 7;181(1-2):126-8. PubMed PMID: 7898751.

4: Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227-34. PubMed PMID: 7800854.

5: Wieland HA, Willim KD, Entzeroth M, Wienen W, Rudolf K, Eberlein W, Engel W, Doods HN. Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther. 1995 Oct;275(1):143-9. PubMed PMID: 7562543.

6: Smith-White M, Moriarty MJ, Potter EK. A comparison of actions of neuropeptide Y (NPY) agonists and antagonists at NPY Y1 and Y2 receptors in anaesthetized rats. Neuropeptides. 1998 Apr;32(2):109-18. PubMed PMID: 9639248.

7: Crowley WR, Ramoz G, Hurst B. Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacol Biochem Behav. 2003 Jan;74(2):417-24. PubMed PMID: 12479963.

8: Oellerich WF, Malik KU. Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1993 Sep;266(3):1321-9. PubMed PMID: 8371140.