WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598031
CAS#: 117667-25-1
Description: Lactoferroxin-A is an opioid antagonist.
MedKoo Cat#: 598031
Name: Lactoferroxin-A
CAS#: 117667-25-1
Chemical Formula: C32H44N6O10
Exact Mass: 672.3119
Molecular Weight: 672.73
Elemental Analysis: C, 57.13; H, 6.59; N, 12.49; O, 23.78
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Synonym: Lactoferroxin-A; Lactoferroxin A; Tyr-leu-gly-ser-gly-tyr-och3;
IUPAC/Chemical Name: methyl L-tyrosyl-L-leucylglycyl-L-serylglycyl-L-tyrosinate
InChi Key: XKVDFADVPPHGJR-CQJMVLFOSA-N
InChi Code: InChI=1S/C32H44N6O10/c1-18(2)12-24(38-29(44)23(33)13-19-4-8-21(40)9-5-19)30(45)34-16-28(43)37-26(17-39)31(46)35-15-27(42)36-25(32(47)48-3)14-20-6-10-22(41)11-7-20/h4-11,18,23-26,39-41H,12-17,33H2,1-3H3,(H,34,45)(H,35,46)(H,36,42)(H,37,43)(H,38,44)/t23-,24-,25-,26-/m0/s1
SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(OC)=O)NC(CNC([C@H](CO)NC(CNC([C@H](CC(C)C)NC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 672.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tani F, Iio K, Chiba H, Yoshikawa M. Isolation and characterization of opioid antagonist peptides derived from human lactoferrin. Agric Biol Chem. 1990 Jul;54(7):1803-10. PubMed PMID: 1369293.
2: Patten GS, Head RJ, Abeywardena MY. Effects of casoxin 4 on morphine inhibition of small animal intestinal contractility and gut transit in the mouse. Clin Exp Gastroenterol. 2011;4:23-31. doi: 10.2147/CEG.S16161. Epub 2011 Feb 10. PubMed PMID: 21694869; PubMed Central PMCID: PMC3108675.
3: Iwan M, Jarmołowska B, Bielikowicz K, Kostyra E, Kostyra H, Kaczmarski M. Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Peptides. 2008 Jun;29(6):1042-7. doi: 10.1016/j.peptides.2008.01.018. Epub 2008 Feb 6. PubMed PMID: 18355944.
