WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598023

CAS#: 114056-26-7

Description: Ota-vasotocin is a ligand used in quantitative receptor autoradiography for oxytocin receptors.

Chemical Structure

CAS# 114056-26-7

Theoretical Analysis

MedKoo Cat#: 598023
Name: Ota-vasotocin
CAS#: 114056-26-7
Chemical Formula: C54H79N11O13S2
Exact Mass: 1153.53
Molecular Weight: 1154.41
Elemental Analysis: C, 56.18; H, 6.90; N, 13.35; O, 18.02; S, 5.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: Ota-vasotocin; OVTA;

IUPAC/Chemical Name: (S)-N1-((R)-1-((S)-2-(((S)-5-amino-1-(((S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-thioxopropan-2-yl)-2-((2S,3R)-3-hydroxy-2-((2S,3S)-2-((S)-3-(4-hydroxyphenyl)-2-(2-(1-mercaptocyclohexyl)acetamido)propanamido)-3-methylpentanamido)butanamido)succinamide


InChi Code: InChI=1S/C54H79N11O13S2/c1-5-30(2)44(63-49(73)38(26-32-13-17-34(67)18-14-32)58-43(69)28-54(80)21-7-6-8-22-54)51(75)64-45(31(3)66)52(76)61-39(27-42(56)68)48(72)62-40(29-79)53(77)65-24-10-12-41(65)50(74)59-36(11-9-23-55)47(71)60-37(46(57)70)25-33-15-19-35(78-4)20-16-33/h13-20,29-31,36-41,44-45,66-67,80H,5-12,21-28,55H2,1-4H3,(H2,56,68)(H2,57,70)(H,58,69)(H,59,74)(H,60,71)(H,61,76)(H,62,72)(H,63,73)(H,64,75)/t30-,31+,36-,37-,38-,39-,40-,41-,44-,45-/m0/s1

SMILES Code: CC[C@@H]([C@H](NC([C@@H](NC(CC1(S)CCCCC1)=O)Cc2ccc(O)cc2)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N)=O)Cc4ccc(OC)cc4)=O)CCCN)=O)=O)C=S)=O)CC(N)=O)=O)[C@H](O)C)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1154.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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4: Fuchs AR, Fields MJ, Chang SM, Thatcher WW, Willard CC, Randel RD. Oxytocin antagonist [1-D(CH2)5,Tyr(ME)2,Thr4,Tyr-NH2(9)]ornithine vasotocin inhibits oxytocin-induced prostaglandin F2alpha release in late-pregnant cows. Biol Reprod. 1997 Aug;57(2):436-41. PubMed PMID: 9241061.

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11: Jankowski M, Wang D, Danalache B, Gangal M, Gutkowska J. Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H265-74. doi: 10.1152/ajpheart.00487.2009. PubMed PMID: 20671291.

12: Caldwell JD, Johns JM, Faggin BM, Senger MA, Pedersen CA. Infusion of an oxytocin antagonist into the medial preoptic area prior to progesterone inhibits sexual receptivity and increases rejection in female rats. Horm Behav. 1994 Sep;28(3):288-302. PubMed PMID: 7814008.

13: Leung CH, Goode CT, Young LJ, Maney DL. Neural distribution of nonapeptide binding sites in two species of songbird. J Comp Neurol. 2009 Mar 10;513(2):197-208. doi: 10.1002/cne.21947. PubMed PMID: 19132730.

14: Pitzel L, Jarry H, Wuttke W. Demonstration of oxytocin receptors in porcine corpora lutea: effects of the cycle stage and the distribution on small and large luteal cells. Biol Reprod. 1993 Mar;48(3):640-6. PubMed PMID: 8384007.

15: Benelli A, Bertolini A, Poggioli R, Menozzi B, Basaglia R, Arletti R. Polymodal dose-response curve for oxytocin in the social recognition test. Neuropeptides. 1995 Apr;28(4):251-5. PubMed PMID: 7596490.

16: Robinzon B, Koike TI, Marks PA. Oxytocin antagonist blocks the vasodepressor but not the vasopressor effect of neurohypophysial peptides in chickens. Peptides. 1994;15(8):1407-13. PubMed PMID: 7700844.

17: Windle RJ, Judah JM, Forsling ML. Effect of oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin in the rat. J Endocrinol. 1997 Feb;152(2):257-64. PubMed PMID: 9071983.

18: Liberzon I, Chalmers DT, Mansour A, Lopez JF, Watson SJ, Young EA. Glucocorticoid regulation of hippocampal oxytocin receptor binding. Brain Res. 1994 Jul 11;650(2):317-22. PubMed PMID: 7953698.

19: Pedersen CA, Johns JM, Musiol I, Perez-Delgado M, Ayers G, Faggin B, Caldwell JD. Interfering with somatosensory stimulation from pups sensitizes experienced, postpartum rat mothers to oxytocin antagonist inhibition of maternal behavior. Behav Neurosci. 1995 Oct;109(5):980-90. PubMed PMID: 8554721.

20: Caldwell JD, Walker CH, Pedersen CA, Barakat AS, Mason GA. Estrogen increases affinity of oxytocin receptors in the medial preoptic area-anterior hypothalamus. Peptides. 1994;15(6):1079-84. PubMed PMID: 7991451.