WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563318

CAS#: 1268273-23-9

Description: YK5 is an inhibitor of an allosteric pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.

Chemical Structure

CAS# 1268273-23-9

Theoretical Analysis

MedKoo Cat#: 563318
Name: YK5
CAS#: 1268273-23-9
Chemical Formula: C18H24N8O3S
Exact Mass: 432.1692
Molecular Weight: 432.5
Elemental Analysis: C, 49.99; H, 5.59; N, 25.91; O, 11.10; S, 7.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: YK5; YK-5; YK 5;

IUPAC/Chemical Name: N-[6-Amino-2-[[4,6-dimethoxy-2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]thio]-4-pyrimidinyl]-2-propenamid


InChi Code: InChI=1S/C18H24N8O3S/c1-5-13(27)21-12-10-11(19)20-18(22-12)30-14-15(28-3)23-17(24-16(14)29-4)26-8-6-25(2)7-9-26/h5,10H,1,6-9H2,2-4H3,(H3,19,20,21,22,27)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 432.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kim JS, Jeong JH, Kim Y. Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. J Microbiol Biotechnol. 2018 Mar 28;28(3):381-390. doi: 10.4014/jmb.1711.11057. PubMed PMID: 29316742.

2: Djegui KY, Gachomo EW, Hounhouigan DJ, Kayodé AP, Kotchoni SO. Biochemical characterization and growth patterns of new yeast isolates. Mol Biol Rep. 2014 Aug;41(8):5199-206. doi: 10.1007/s11033-014-3387-z. Epub 2014 May 7. PubMed PMID: 24802797.

3: Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. PubMed PMID: 24239008; PubMed Central PMCID: PMC3985611.

4: Iida T, Nakamura K, Izumi A, Mukouzaka Y, Kudo T. Isolation and characterization of a gene cluster for dibenzofuran degradation in a new dibenzofuran-utilizing bacterium, Paenibacillus sp. strain YK5. Arch Microbiol. 2006 Jan;184(5):305-15. Epub 2005 Nov 12. PubMed PMID: 16284749.