WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597897

CAS#: 157476-77-2

Description: Lagatide is a synthetic heptapeptide with antisecretory activity.

Chemical Structure

CAS# 157476-77-2

Theoretical Analysis

MedKoo Cat#: 597897
Name: Lagatide
CAS#: 157476-77-2
Chemical Formula: C33H58N10O9
Exact Mass: 738.4388
Molecular Weight: 738.88
Elemental Analysis: C, 53.64; H, 7.91; N, 18.96; O, 19.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Lagatide;

IUPAC/Chemical Name: (S)-2-((S)-1-(L-prolyl-L-valyl-L-threonyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((R)-1-amino-1-oxopropan-2-yl)pentanediamide


InChi Code: InChI=1S/C33H58N10O9/c1-17(2)25(41-28(47)20-10-7-15-37-20)31(50)42-26(19(4)44)32(51)40-22(9-5-6-14-34)33(52)43-16-8-11-23(43)30(49)39-21(12-13-24(35)45)29(48)38-18(3)27(36)46/h17-23,25-26,37,44H,5-16,34H2,1-4H3,(H2,35,45)(H2,36,46)(H,38,48)(H,39,49)(H,40,51)(H,41,47)(H,42,50)/t18-,19-,20+,21+,22+,23+,25+,26+/m1/s1

SMILES Code: C[C@H](C(N)=O)NC([C@H](CCC(N)=O)NC([C@H]1N(C([C@H](CCCCN)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H]2NCCC2)=O)=O)=O)=O)CCC1)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 738.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Couturaud B, Baldo A, Mas A, Robin JJ. Improvement of the interfacial compatibility between cellulose and poly(L-lactide) films by plasma-induced grafting of L-lactide: the evaluation of the adhesive properties using a peel test. J Colloid Interface Sci. 2015 Jun 15;448:427-36. doi: 10.1016/j.jcis.2015.02.035. Epub 2015 Feb 21. PubMed PMID: 25752580.

2: Zhu JB, Chen EY. From meso-Lactide to Isotactic Polylactide: Epimerization by B/N Lewis Pairs and Kinetic Resolution by Organic Catalysts. J Am Chem Soc. 2015 Oct 7;137(39):12506-9. doi: 10.1021/jacs.5b08658. Epub 2015 Sep 24. PubMed PMID: 26388298.

3: Franke JH, Kosov DS. Adsorption and ring-opening of lactide on the chiral metal surface Pt(321)(S) studied by density functional theory. J Chem Phys. 2015 Jan 28;142(4):044703. doi: 10.1063/1.4906151. PubMed PMID: 25637999.

4: Messias AD, Martins KF, Motta AC, Duek EA. Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds. Int J Biomater. 2014;2014:501789. doi: 10.1155/2014/501789. Epub 2014 Jun 25. PubMed PMID: 25053947; PubMed Central PMCID: PMC4099256.

5: Kum CH, Cho Y, Seo SH, Joung YK, Ahn DJ, Han DK. A poly(lactide) stereocomplex structure with modified magnesium oxide and its effects in enhancing the mechanical properties and suppressing inflammation. Small. 2014 Sep 24;10(18):3783-94. doi: 10.1002/smll.201302880. Epub 2014 May 12. PubMed PMID: 24820693.

6: Fortun S, Daneshmand P, Schaper F. Isotactic rac-Lactide Polymerization with Copper Complexes: The Influence of Complex Nuclearity. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13669-72. doi: 10.1002/anie.201505674. Epub 2015 Sep 16. PubMed PMID: 26373620.

7: Gilmour DJ, Webster RL, Perry MR, Schafer LL. Titanium pyridonates for the homo- and copolymerization of rac-lactide and ε-caprolactone. Dalton Trans. 2015 Jul 21;44(27):12411-9. doi: 10.1039/c5dt01162k. PubMed PMID: 26018788.

8: Sun Y, Cui Y, Xiong J, Dai Z, Tang N, Wu J. Different mechanisms at different temperatures for the ring-opening polymerization of lactide catalyzed by binuclear magnesium and zinc alkoxides. Dalton Trans. 2015 Oct 7;44(37):16383-91. doi: 10.1039/c5dt01784j. PubMed PMID: 26308730.

9: Devaine-Pressing K, Lehr JH, Pratt ME, Dawe LN, Sarjeant AA, Kozak CM. Magnesium amino-bis(phenolato) complexes for the ring-opening polymerization of rac-lactide. Dalton Trans. 2015 Jul 21;44(27):12365-75. doi: 10.1039/c5dt00236b. PubMed PMID: 25805063.

10: Li Y, Huang X, Zhang M, Li Y, Chen Y, Jia J. [BIOCOMPATIBILITY OF POLY-LACTIDE-CO-GLYCOLIDE/COLLAGEN TYPE I SCAFFOLD WITH RAT VAGINAL EPITHELIAL CELLS]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2015 Sep;29(9):1144-9. Chinese. PubMed PMID: 26750017.

11: Van Wouwe P, Dusselier M, Vanleeuw E, Sels B. Lactide Synthesis and Chirality Control for Polylactic acid Production. ChemSusChem. 2016 May 10;9(9):907-21. doi: 10.1002/cssc.201501695. Epub 2016 Apr 13. Review. PubMed PMID: 27071863.

12: Larrañaga A, Alonso-Varona A, Palomares T, Rubio-Azpeitia E, Aldazabal P, Martin FJ, Sarasua JR. Effect of bioactive glass particles on osteogenic differentiation of adipose-derived mesenchymal stem cells seeded on lactide and caprolactone based scaffolds. J Biomed Mater Res A. 2015 Dec;103(12):3815-24. doi: 10.1002/jbm.a.35525. Epub 2015 Jul 1. PubMed PMID: 26074489.

13: Stukenbroeker TS, Bandar JS, Zhang X, Lambert TH, Waymouth RM. Cyclopropenimine Superbases: Competitive Initiation Processes in Lactide Polymerization. ACS Macro Lett. 2015 Aug 18;4(8):853-856. Epub 2015 Jul 30. PubMed PMID: 26913218; PubMed Central PMCID: PMC4762272.

14: Ma P, Jiang L, Xu P, Dong W, Chen M, Lemstra PJ. Rapid Stereocomplexation between Enantiomeric Comb-Shaped Cellulose-g-poly(L-lactide) Nanohybrids and Poly(D-lactide) from the Melt. Biomacromolecules. 2015 Nov 9;16(11):3723-9. doi: 10.1021/acs.biomac.5b01135. Epub 2015 Oct 7. PubMed PMID: 26444105.

15: Zhao Y, Zhou Y, Wang D, Gao Y, Li J, Ma S, Zhao L, Zhang C, Liu Y, Li X. pH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-glycoprotein inhibitor. Acta Biomater. 2015 Apr;17:182-92. doi: 10.1016/j.actbio.2015.01.010. Epub 2015 Jan 19. PubMed PMID: 25612838.

16: Tang XJ, Huang J, Xu LY, Li Y, Song J, Ma Y, Yang L, Yuan D, Wu HY. Microwave-assisted rapid synthesis, characterization and application of poly (D,L-lactide)-graft-pullulan. Carbohydr Polym. 2014 Jul 17;107:7-15. doi: 10.1016/j.carbpol.2014.02.038. Epub 2014 Feb 20. PubMed PMID: 24702912.

17: Ardeshirylajimi A, Mossahebi-Mohammadi M, Vakilian S, Langroudi L, Seyedjafari E, Atashi A, Soleimani M. Comparison of osteogenic differentiation potential of human adult stem cells loaded on bioceramic-coated electrospun poly (L-lactide) nanofibres. Cell Prolif. 2015 Feb;48(1):47-58. doi: 10.1111/cpr.12156. Epub 2014 Dec 11. PubMed PMID: 25495212.

18: Yang JH, Lee JY, Chin IJ. Reinforcing Effects of Poly(D-Lactide)-g-Multiwall Carbon Nanotubes on Polylactide Nanocomposites. J Nanosci Nanotechnol. 2015 Oct;15(10):8086-92. PubMed PMID: 26726467.

19: Tseng YY, Liao JY, Chen WA, Kao YC, Liu SJ. Biodegradable poly([D,L]-lactide-co-glycolide) nanofibers for the sustainable delivery of lidocaine into the epidural space after laminectomy. Nanomedicine (Lond). 2014 Jan;9(1):77-87. doi: 10.2217/nnm.13.42. Epub 2013 Jun 26. PubMed PMID: 23799985.

20: Kim S, Bedigrew K, Guda T, Maloney WJ, Park S, Wenke JC, Yang YP. Novel osteoinductive photo-cross-linkable chitosan-lactide-fibrinogen hydrogels enhance bone regeneration in critical size segmental bone defects. Acta Biomater. 2014 Dec;10(12):5021-5033. doi: 10.1016/j.actbio.2014.08.028. Epub 2014 Aug 28. PubMed PMID: 25174669; PubMed Central PMCID: PMC4252590.