PU3

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563303

CAS#: 352519-21-2

Description: PU3 is an Hsp90 inhibitor.


Chemical Structure

img
PU3
CAS# 352519-21-2

Theoretical Analysis

MedKoo Cat#: 563303
Name: PU3
CAS#: 352519-21-2
Chemical Formula: C19H25N5O3
Exact Mass: 371.20
Molecular Weight: 371.440
Elemental Analysis: C, 61.44; H, 6.78; N, 18.85; O, 12.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PU3; PU-3; PU 3;

IUPAC/Chemical Name: 9-Butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine

InChi Key: TUOSCZDRWRYPRS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N5O3/c1-5-6-7-24-15(23-16-18(20)21-11-22-19(16)24)10-12-8-13(25-2)17(27-4)14(9-12)26-3/h8-9,11H,5-7,10H2,1-4H3,(H2,20,21,22)

SMILES Code: NC1=C2N=C(CC3=CC(OC)=C(OC)C(OC)=C3)N(CCCC)C2=NC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li W, Jiang N, Li B, Wan M, Chang X, Liu H, Zhang L, Yin S, Qi H, Liu S. Antioxidant activity of purified ulvan in hyperlipidemic mice. Int J Biol Macromol. 2018 Jul 1;113:971-975. doi: 10.1016/j.ijbiomac.2018.02.104. Epub 2018 Feb 21. PubMed PMID: 29476858.

2: Cary SK, Galley SS, Marsh ML, Hobart DL, Baumbach RE, Cross JN, Stritzinger JT, Polinski MJ, Maron L, Albrecht-Schmitt TE. Incipient class II mixed valency in a plutonium solid-state compound. Nat Chem. 2017 Sep;9(9):856-861. doi: 10.1038/nchem.2777. Epub 2017 May 8. PubMed PMID: 28837172.

3: Jeong JH, Oh YJ, Kwon TK, Seo YH. Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC). Arch Pharm Res. 2017 Jan;40(1):96-105. doi: 10.1007/s12272-016-0848-z. Epub 2016 Oct 21. PubMed PMID: 27770383.

4: Jiang J, Li L, Li K, Li G, You F, Zuo Y, Li Y, Li J. Antibacterial nanohydroxyapatite/polyurethane composite scaffolds with silver phosphate particles for bone regeneration. J Biomater Sci Polym Ed. 2016 Nov;27(16):1584-98. doi: 10.1080/09205063.2016.1221699. Epub 2016 Aug 19. PubMed PMID: 27501157.

5: Sweetser PW, Hilton EJ. Osteology of the crescent gunnel Pholis laeta and the phylogeny of the family Pholidae (Cottiformes, Zoarcoidei). J Fish Biol. 2016 Sep;89(3):1666-91. doi: 10.1111/jfb.13084. Epub 2016 Jul 27. PubMed PMID: 27460961.

6: Trendowski M. PU-H71: An improvement on nature's solutions to oncogenic Hsp90 addiction. Pharmacol Res. 2015 Sep;99:202-16. doi: 10.1016/j.phrs.2015.06.007. Epub 2015 Jun 25. Review. PubMed PMID: 26117427.

7: Wang J, Zuo Y, Zhao M, Jiang J, Man Y, Wu J, Hu Y, Liu C, Li Y, Li J. Physicochemical and biological properties of a novel injectable polyurethane system for root canal filling. Int J Nanomedicine. 2015 Jan 17;10:697-709. doi: 10.2147/IJN.S74025. eCollection 2015. PubMed PMID: 25653518; PubMed Central PMCID: PMC4303460.

8: Dunna NR, Bandaru S, Akare UR, Rajadhyax S, Gutlapalli VR, Yadav M, Nayarisseri A. Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target. Curr Top Med Chem. 2015;15(1):57-64. PubMed PMID: 25579569.

9: Jeong CH, Park HB, Jang WJ, Jung SH, Seo YH. Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC). Bioorg Med Chem Lett. 2014 Jan 1;24(1):224-7. doi: 10.1016/j.bmcl.2013.11.034. Epub 2013 Nov 22. PubMed PMID: 24345447.

10: Li G, Liu Y, Li D, Zhang L, Xu K. A comparative study on structure-property elucidation of P3/4HB and PEG-based block polyurethanes. J Biomed Mater Res A. 2012 Sep;100(9):2319-29. doi: 10.1002/jbm.a.34173. Epub 2012 Apr 24. PubMed PMID: 22529029.

11: Yi WP, Sun Z, Wu L, Shi GF, Zhu GL, Li YX, Gu JL, Xu QM. [Effects of coated controlled release urea combined with conventional urea on winter wheat growth and soil NO3- -N]. Ying Yong Sheng Tai Xue Bao. 2011 Mar;22(3):687-93. Chinese. PubMed PMID: 21657025.

12: Li G, Li P, Qiu H, Li D, Su M, Xu K. Synthesis, characterizations and biocompatibility of alternating block polyurethanes based on P3/4HB and PPG-PEG-PPG. J Biomed Mater Res A. 2011 Jul;98(1):88-99. doi: 10.1002/jbm.a.33100. Epub 2011 Apr 28. PubMed PMID: 21538829.

13: Ou W, Qiu H, Chen Z, Xu K. Biodegradable block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers. Biomaterials. 2011 Apr;32(12):3178-88. doi: 10.1016/j.biomaterials.2011.01.031. Epub 2011 Feb 18. PubMed PMID: 21310479.

14: So JW, Kim S, Park JS, Kim BH, Jung SH, Shin SC, Cho CW. Preparation and evaluation of solid lipid nanoparticles with JSH18 for skin-whitening efficacy. Pharm Dev Technol. 2010 Jul-Aug;15(4):415-20. doi: 10.3109/10837450903262066. PubMed PMID: 19775236.

15: Hung WC, Shau MD, Kao HC, Shih MF, Cherng JY. The synthesis of cationic polyurethanes to study the effect of amines and structures on their DNA transfection potential. J Control Release. 2009 Jan 5;133(1):68-76. doi: 10.1016/j.jconrel.2008.09.082. Epub 2008 Oct 4. PubMed PMID: 18930774.

16: Yan A, Grant GH, Richards WG. Dynamics of conserved waters in human Hsp90: implications for drug design. J R Soc Interface. 2008 Dec 6;5 Suppl 3:S199-205. doi: 10.1098/rsif.2008.0331.focus. PubMed PMID: 18826913; PubMed Central PMCID: PMC2586097.

17: Muranaka K, Sano A, Ichikawa S, Matsuda A. Synthesis of Hsp90 inhibitor dimers as potential antitumor agents. Bioorg Med Chem. 2008 Jun 1;16(11):5862-70. doi: 10.1016/j.bmc.2008.04.070. Epub 2008 May 1. PubMed PMID: 18487051.

18: Luksiene B, Druteikiene R. Study of plutonium migration and/or accumulation in soil under field and laboratory conditions. Arh Hig Rada Toksikol. 2006 Mar;57(1):17-22. PubMed PMID: 16605162.

19: Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE. Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. Chem Biol. 2004 Jun;11(6):775-85. PubMed PMID: 15217611.

20: Liu HC, Lyu PC, Leong MK, Tsai KC, Hsiue GH. 3D-QSAR studies on PU3 analogues by comparative molecular field analysis. Bioorg Med Chem Lett. 2004 Feb 9;14(3):731-4. PubMed PMID: 14741278.