WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563301
Description: 6CEPN is an inhibitor of Cyclooxygenase-1 that acts by suppressing colorectal cancer growth.
MedKoo Cat#: 563301
Chemical Formula: C23H18O5
Exact Mass: 374.1154
Molecular Weight: 374.39
Elemental Analysis: C, 73.79; H, 4.85; O, 21.37
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: 6CEPN; 6-CEPN; 6 CEPN;
IUPAC/Chemical Name: (E)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-styrylchroman-4-one
InChi Key: WBONVHMXTSZBAF-IZZDOVSWSA-N
InChi Code: InChI=1S/C23H18O5/c24-16-9-7-15(8-10-16)20-13-19(26)22-21(28-20)12-18(25)17(23(22)27)11-6-14-4-2-1-3-5-14/h1-12,20,24-25,27H,13H2/b11-6+
SMILES Code: O=C1CC(C2=CC=C(O)C=C2)OC3=C1C(O)=C(/C=C/C4=CC=CC=C4)C(O)=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 374.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li H, Zhu F, Chen H, Cheng KW, Zykova T, Oi N, Lubet RA, Bode AM, Wang M, Dong Z. 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. Cancer Res. 2014 Jan 1;74(1):243-52. doi: 10.1158/0008-5472.CAN-13-2245. Epub 2013 Nov 12. PubMed PMID: 24220240; PubMed Central PMCID: PMC3947334.