TEMPO
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MedKoo CAT#: 592227

CAS#: 2564-83-2

Description: TEMPO (2,2,6,6-Tetramethyl-1-piperidinyloxy) is a stable nitroxide radical useful in controlling living polymerizations.


Chemical Structure

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TEMPO
CAS# 2564-83-2

Theoretical Analysis

MedKoo Cat#: 592227
Name: TEMPO
CAS#: 2564-83-2
Chemical Formula: C9H18NO.
Exact Mass: 156.14
Molecular Weight: 156.250
Elemental Analysis: C, 69.18; H, 11.61; N, 8.96; O, 10.24

Price and Availability

Size Price Availability Quantity
1g USD 215
5g USD 550
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Synonym: AI3-51508; AI3 51508; AI351508; TEMPO

IUPAC/Chemical Name: 1-Piperidinyloxy, 2,2,6,6-tetramethyl- (9CI)

InChi Key: QYTDEUPAUMOIOP-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H18NO/c1-8(2)6-5-7-9(3,4)10(8)11/h5-7H2,1-4H3

SMILES Code: [O]N1C(C)(C)CCCC1(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 156.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu S, Liang H, Sun T, Yang D, Cao M. A recoverable dendritic polyamidoamine immobilized TEMPO for efficient catalytic oxidation of cellulose. Carbohydr Polym. 2018 Dec 15;202:563-570. doi: 10.1016/j.carbpol.2018.09.016. Epub 2018 Sep 13. PubMed PMID: 30287037.

2: Guo X, Seo JE, Bryce SM, Tan JA, Wu Q, Dial SL, Moore MM, Mei N. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. doi: 10.1093/toxsci/kfy022. PubMed PMID: 29385624; PubMed Central PMCID: PMC6388407.

3: Zhou Y, Saito T, Bergström L, Isogai A. Acid-Free Preparation of Cellulose Nanocrystals by TEMPO Oxidation and Subsequent Cavitation. Biomacromolecules. 2018 Feb 12;19(2):633-639. doi: 10.1021/acs.biomac.7b01730. Epub 2018 Jan 16. PubMed PMID: 29283555.

4: Li J, Zhang J, Chen Y, Kawazoe N, Chen G. TEMPO-Conjugated Gold Nanoparticles for Reactive Oxygen Species Scavenging and Regulation of Stem Cell Differentiation. ACS Appl Mater Interfaces. 2017 Oct 18;9(41):35683-35692. doi: 10.1021/acsami.7b12486. Epub 2017 Oct 4. PubMed PMID: 28944661.

5: Fu Q, Sutherland A, Gustafsson E, Ali MM, Soleymani L, Pelton R. Relating Redox Properties of Polyvinylamine-g-TEMPO/Laccase Hydrogel Complexes to Cellulose Oxidation. Langmuir. 2017 Aug 15;33(32):7854-7861. doi: 10.1021/acs.langmuir.7b01460. Epub 2017 Aug 3. PubMed PMID: 28732155.

6: Spier VC, Sierakowski MR, Reed WF, de Freitas RA. Polysaccharide depolymerization from TEMPO-catalysis: Effect of TEMPO concentration. Carbohydr Polym. 2017 Aug 15;170:140-147. doi: 10.1016/j.carbpol.2017.04.064. Epub 2017 Apr 26. PubMed PMID: 28521979.

7: Jiang J, Ye W, Liu L, Wang Z, Fan Y, Saito T, Isogai A. Cellulose Nanofibers Prepared Using the TEMPO/Laccase/O(2) System. Biomacromolecules. 2017 Jan 9;18(1):288-294. doi: 10.1021/acs.biomac.6b01682. Epub 2016 Dec 20. PubMed PMID: 27995786.

8: Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. doi: 10.1007/s00204-016-1692-0. Epub 2016 Mar 22. PubMed PMID: 27002509; PubMed Central PMCID: PMC5033665.