Aminoacridine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592220

CAS#: 90-45-9

Description: Aminoacridine is a highly fluorescent dye used as a topical antiseptic. It is sometimes used experimentally as a mutagen due to its interaction with DNA. It is also used as an intracellular pH indicator.

Chemical Structure

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Aminoacridine
CAS# 90-45-9
Instruction

Theoretical Analysis

MedKoo Cat#: 592220
Name: Aminoacridine
CAS#: 90-45-9
Chemical Formula: C13H10N2
Exact Mass: 194.08
Molecular Weight: 194.240
Elemental Analysis: C, 80.39; H, 5.19; N, 14.42

Price and Availability

Size Price Availability Quantity
1g USD 235
5g USD 625
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Synonym: Aminoacridine; NSC 13000; NSC-13000; NSC13000

IUPAC/Chemical Name: 9-Acridinamine

InChi Key: XJGFWWJLMVZSIG-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)

SMILES Code: NC1=C(C=CC=C2)C2=NC3=CC=CC=C31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 194.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhou Q, You C, Zheng C, Gu Y, Gu H, Zhang R, Wu H, Sun B. 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents. Life Sci. 2018 Aug 1;206:1-9. doi: 10.1016/j.lfs.2018.05.010. Epub 2018 May 5. PubMed PMID: 29738780.

2: Loddo R, Francesconi V, Laurini E, Boccardo S, Aulic S, Fermeglia M, Pricl S, Tonelli M. 9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp). Bioorg Med Chem. 2018 Feb 15;26(4):855-868. doi: 10.1016/j.bmc.2018.01.001. Epub 2018 Jan 4. PubMed PMID: 29325885.

3: Solomon VR, Pundir S, Le HT, Lee H. Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity. Eur J Med Chem. 2018 Jan 1;143:1028-1038. doi: 10.1016/j.ejmech.2017.11.097. PubMed PMID: 29232580.

4: Solomon VR, Almnayan D, Lee H. Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad. Eur J Med Chem. 2017 Sep 8;137:156-166. doi: 10.1016/j.ejmech.2017.05.052. Epub 2017 May 27. PubMed PMID: 28586716.