WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597872
CAS#: 151367-91-8
Description: Pyroglutamylglutamine diketopiperazine is a bioactive chemical.
MedKoo Cat#: 597872
Name: Pyroglutamylglutamine diketopiperazine
CAS#: 151367-91-8
Chemical Formula: C20H23ClN2O3
Exact Mass: 374.1397
Molecular Weight: 374.86
Elemental Analysis: C, 64.08; H, 6.18; Cl, 9.46; N, 7.47; O, 12.80
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Pyroglutamylglutamine diketopiperazine; Pglu-glu dkm;
IUPAC/Chemical Name: 2-(benzhydrylamino)-2-oxoethyl L-prolinate hydrochloride
InChi Key: LBFARVNDABEYOE-LMOVPXPDSA-N
InChi Code: InChI=1S/C20H22N2O3.ClH/c23-18(14-25-20(24)17-12-7-13-21-17)22-19(15-8-3-1-4-9-15)16-10-5-2-6-11-16;/h1-6,8-11,17,19,21H,7,12-14H2,(H,22,23);1H/t17-;/m0./s1
SMILES Code: O=C(OCC(NC(C1=CC=CC=C1)C2=CC=CC=C2)=O)[C@H]3NCCC3.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 374.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mazurov AA, Andronati SA, Korotenko TI, Gorbatyuk VYa, Shapiro YE. Formation of pyroglutamylglutamine (or asparagine) diketopiperazine in 'non-classical' conditions: a side reaction in peptide synthesis. Int J Pept Protein Res. 1993 Jul;42(1):14-9. PubMed PMID: 8370638.
