ICI 200355

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597826

CAS#: 105080-32-8

Description: ICI 200355 is a human neutrophil elastase inhibitor.


Chemical Structure

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ICI 200355
CAS# 105080-32-8

Theoretical Analysis

MedKoo Cat#: 597826
Name: ICI 200355
CAS#: 105080-32-8
Chemical Formula: C30H34BrF3N4O7S
Exact Mass: 730.1284
Molecular Weight: 731.58
Elemental Analysis: C, 49.25; H, 4.68; Br, 10.92; F, 7.79; N, 7.66; O, 15.31; S, 4.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI 200355; ICI-200355; ICI200355; ICI-200,355; ICI 200,355; ICI200,355;

IUPAC/Chemical Name: N1-((4-bromophenyl)sulfonyl)-N4-((2S)-3-methyl-1-oxo-1-((2S)-2-((1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl)pyrrolidin-1-yl)butan-2-yl)terephthalamide

InChi Key: UUWIYANOKPHUQZ-OTKIHZFJSA-N

InChi Code: InChI=1S/C30H34BrF3N4O7S/c1-16(2)23(25(39)30(32,33)34)35-28(42)22-6-5-15-38(22)29(43)24(17(3)4)36-26(40)18-7-9-19(10-8-18)27(41)37-46(44,45)21-13-11-20(31)12-14-21/h7-14,16-17,22-24H,5-6,15H2,1-4H3,(H,35,42)(H,36,40)(H,37,41)/t22-,23?,24-/m0/s1

SMILES Code: O=C(NC(C(C)C)C(C(F)(F)F)=O)[C@H]1N(C([C@H](C(C)C)NC(C2=CC=C(C(NS(=O)(C3=CC=C(Br)C=C3)=O)=O)C=C2)=O)=O)CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 731.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sommerhoff CP, Krell RD, Williams JL, Gomes BC, Strimpler AM, Nadel JA. Inhibition of human neutrophil elastase by ICI 200,355. Eur J Pharmacol. 1991 Feb 7;193(2):153-8. PubMed PMID: 2050195.

2: Williams JC, Falcone RC, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE, Krell RD. Biologic characterization of ICI 200,880 and ICI 200,355, novel inhibitors of human neutrophil elastase. Am Rev Respir Dis. 1991 Oct;144(4):875-83. PubMed PMID: 1928965.

3: Schuster A, Ueki I, Nadel JA. Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355. Am J Physiol. 1992 Jan;262(1 Pt 1):L86-91. PubMed PMID: 1370750.

4: Fahy JV, Schuster A, Ueki I, Boushey HA, Nadel JA. Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases. Am Rev Respir Dis. 1992 Dec;146(6):1430-3. PubMed PMID: 1280928.

5: Llewellyn-Jones CG, Lomas DA, Stockley RA. Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation. Thorax. 1994 Jun;49(6):567-72. PubMed PMID: 7912452; PubMed Central PMCID: PMC474946.

6: O'Riordan TG, Otero R, Mao Y, Lauredo I, Abraham WM. Elastase contributes to antigen-induced mucociliary dysfunction in ovine airways. Am J Respir Crit Care Med. 1997 May;155(5):1522-8. PubMed PMID: 9154852.

7: Cardell LO, Agustí C, Takeyama K, Stjärne P, Nadel JA. LTB(4)-induced nasal gland serous cell secretion mediated by neutrophil elastase. Am J Respir Crit Care Med. 1999 Aug;160(2):411-4. PubMed PMID: 10430706.

8: Turino GM, Davies P, Dunlap R, Krell RD, Maycock AL, Rennard S, Stockley RA. Selection of a therapeutic agent for the treatment of chronic obstructive pulmonary disease in smokers. Ann N Y Acad Sci. 1991 Dec 31;624 Suppl:23-30. PubMed PMID: 1686162.

9: Scuri M, Forteza R, Lauredo I, Sabater JR, Botvinnikova Y, Allegra L, Abraham WM. Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism. J Appl Physiol (1985). 2000 Oct;89(4):1397-402. PubMed PMID: 11007574.

10: Takeyama K, Agustí C, Ueki I, Lausier J, Cardell LO, Nadel JA. Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules. Am J Physiol. 1998 Aug;275(2 Pt 1):L294-302. PubMed PMID: 9700090.

11: Witko-Sarsat V, Halbwachs-Mecarelli L, Schuster A, Nusbaum P, Ueki I, Canteloup S, Lenoir G, Descamps-Latscha B, Nadel JA. Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum. Am J Respir Cell Mol Biol. 1999 Apr;20(4):729-36. PubMed PMID: 10101005.

12: Forteza R, Botvinnikova Y, Ahmed A, Cortes A, Gundel RH, Wanner A, Abraham WM. The interaction of alpha 1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness. Am J Respir Crit Care Med. 1996 Jul;154(1):36-42. PubMed PMID: 8680696.

13: Ahn CM, Sandler H, Glass M, Saldeen T. Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat. Exp Lung Res. 1993 Mar-Apr;19(2):125-35. PubMed PMID: 8467758.

14: Tabachnik E, Schuster A, Gold WM, Nadel JA. Role of neutrophil elastase in allergen-induced lysozyme secretion in the dog trachea. J Appl Physiol (1985). 1992 Aug;73(2):695-700. PubMed PMID: 1399999.

15: Bernstein PR, Gomes BC, Kosmider BJ, Vacek EP, Williams JC. Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone. J Med Chem. 1995 Jan 6;38(1):212-5. PubMed PMID: 7837235.

16: Ahn CM, Sandler H, Saldeen T. A leukocyte elastase inhibitor reduces thrombin-induced pulmonary oedema in the rat: mechanisms of action. Pulm Pharmacol Ther. 1998;11(4):291-9. PubMed PMID: 10101747.

17: Veale CA, Bernstein PR, Bohnert CM, Brown FJ, Bryant C, Damewood JR Jr, Earley R, Feeney SW, Edwards PD, Gomes B, Hulsizer JM, Kosmider BJ, Krell RD, Moore G, Salcedo TW, Shaw A, Silberstein DS, Steelman GB, Stein M, Strimpler A, Thomas RM, Vacek EP, Williams JC, Wolanin DJ, Woolson S. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem. 1997 Sep 26;40(20):3173-81. PubMed PMID: 9379436.

18: Schuster A, Fahy JV, Ueki I, Nadel JA. Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. Eur Respir J. 1995 Jan;8(1):10-4. PubMed PMID: 7744174.

19: Agusti C, Takeyama K, Cardell LO, Ueki I, Lausier J, Lou YP, Nadel JA. Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils. Am J Respir Crit Care Med. 1998 Oct;158(4):1253-8. PubMed PMID: 9769289.

20: Starcher B, O'Neal P, Granstein RD, Beissert S. Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice. J Invest Dermatol. 1996 Aug;107(2):159-63. PubMed PMID: 8757756.