Ecdysone | CAS#3604-87-3 |

Ecdysone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592171

CAS#: 3604-87-3

Description: Ecdysone is a steroid hormone that regulates the processes of MOLTING or ecdysis in insects.

Chemical Structure

Ecdysone

CAS# 3604-87-3

Instruction

Theoretical Analysis

MedKoo Cat#: 592171
Name: Ecdysone
CAS#: 3604-87-3
Chemical Formula: C27H44O6
Exact Mass: 464.31
Molecular Weight: 464.640
Elemental Analysis: C, 69.79; H, 9.55; O, 20.66

Price and Availability

Size	Price	Availability
5mg	USD 340	2 weeks
10mg	USD 540	2 weeks
25mg	USD 960	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Ecdysone

IUPAC/Chemical Name: 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,22,25-pentahydroxy-, (20S,22R)-

InChi Key: UPEZCKBFRMILAV-JMZLNJERSA-N

InChi Code: InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1

SMILES Code: CC(C)(O)CC[C@@H](O)[C@@H](C)[C@H]1CC[C@@]2(O)C3=CC([C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 464.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lee YS, Lee SE, Son J, Kim Y, Wee J, Cho K. Toxicity effects and biomarkers of tebufenozide exposure in Yuukianura szeptyckii (Collembola: Neanuridae). Environ Geochem Health. 2018 Jul 6. doi: 10.1007/s10653-018-0143-7. [Epub ahead of print] PubMed PMID: 29981014.

2: Vishal K, Bawa S, Brooks D, Bauman K, Geisbrecht ER. Thin is required for cell death in the Drosophila abdominal muscles by targeting DIAP1. Cell Death Dis. 2018 Jul 3;9(7):740. doi: 10.1038/s41419-018-0756-x. PubMed PMID: 29970915; PubMed Central PMCID: PMC6030163.

3: Song Z, Yang YP, Xu WH. PTEN expression responds to transcription factor POU and regulates p-AKT levels during diapause initiation in the cotton bollworm, Helicoverpa armigera. Insect Biochem Mol Biol. 2018 Jun 27. pii: S0965-1748(18)30134-6. doi: 10.1016/j.ibmb.2018.06.005. [Epub ahead of print] PubMed PMID: 29959976.

4: Denton D, Xu T, Dayan S, Nicolson S, Kumar S. Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production. Cell Death Differ. 2018 Jun 29. doi: 10.1038/s41418-018-0154-z. [Epub ahead of print] PubMed PMID: 29959404.

5: Lin H, Liu X, Ma Y, Pang K, Hu J. Residue analysis and dietary exposure risk assessment of tebufenozide in stem lettuce (Lactuca sativa L. var. angustana Irish). Food Chem Toxicol. 2018 Jun 26;120:64-70. doi: 10.1016/j.fct.2018.06.057. [Epub ahead of print] PubMed PMID: 29958988.

6: Masuoka Y, Toga K, Nalepa CA, Maekawa K. A Crucial Caste Regulation Gene Detected by Comparing Termites and Sister Group Cockroaches. Genetics. 2018 Jun 22. pii: genetics.301038.2018. doi: 10.1534/genetics.118.301038. [Epub ahead of print] PubMed PMID: 29934338.

7: Sun Z, Shi Q, Xu C, Wang R, Wang H, Song Y, Zeng R. Regulation of NlE74A on vitellogenin may be mediated by angiotensin converting enzyme through a fecundity-related SNP in the brown planthopper, Nilaparvata lugens. Comp Biochem Physiol A Mol Integr Physiol. 2018 Jun 20;225:26-32. doi: 10.1016/j.cbpa.2018.06.009. [Epub ahead of print] PubMed PMID: 29932974.

8: González-Itier S, Contreras EG, Larraín J, Glavic Á, Faunes F. A role for Lin-28 in growth and metamorphosis in Drosophila melanogaster. Mech Dev. 2018 Jun 14. pii: S0925-4773(18)30040-6. doi: 10.1016/j.mod.2018.06.002. [Epub ahead of print] PubMed PMID: 29908237.

9: Crocker KC, Hunter MD. Environmental causes and transgenerational consequences of ecdysteroid hormone provisioning in Acheta domesticus. J Insect Physiol. 2018 Jun 8;109:69-78. doi: 10.1016/j.jinsphys.2018.06.003. [Epub ahead of print] PubMed PMID: 29890170.

10: Wang ZZ, Ye XQ, Shi M, Li F, Wang ZH, Zhou YN, Gu QJ, Wu XT, Yin CL, Guo DH, Hu RM, Hu NN, Chen T, Zheng BY, Zou JN, Zhan LQ, Wei SJ, Wang YP, Huang JH, Fang XD, Strand MR, Chen XX. Parasitic insect-derived miRNAs modulate host development. Nat Commun. 2018 Jun 7;9(1):2205. doi: 10.1038/s41467-018-04504-1. PubMed PMID: 29880839; PubMed Central PMCID: PMC5992160.

11: Prud'homme SM, Renault D, David JP, Reynaud S. Multiscale Approach to Deciphering the Molecular Mechanisms Involved in the Direct and Intergenerational Effect of Ibuprofen on Mosquito Aedes aegypti. Environ Sci Technol. 2018 Jun 25. doi: 10.1021/acs.est.8b00988. [Epub ahead of print] PubMed PMID: 29874051.

12: Zheng W, Rus F, Hernandez A, Kang P, Goldman W, Silverman N, Tatar M. Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells. BMC Biol. 2018 May 31;16(1):60. doi: 10.1186/s12915-018-0532-5. PubMed PMID: 29855367; PubMed Central PMCID: PMC5984326.

13: Tran NL, Takaesu NT, Cornell EF, Newfeld SJ. CORL Expression in the Drosophila Central Nervous System Is Regulated by Stage Specific Interactions of Intertwined Activators and Repressors. G3 (Bethesda). 2018 Jul 2;8(7):2527-2536. doi: 10.1534/g3.118.200282. PubMed PMID: 29848623; PubMed Central PMCID: PMC6027887.

14: Lee GJ, Han G, Yun HM, Lim JJ, Noh S, Lee J, Hyun S. Steroid signaling mediates nutritional regulation of juvenile body growth via IGF-binding protein in Drosophila. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5992-5997. doi: 10.1073/pnas.1718834115. Epub 2018 May 21. PubMed PMID: 29784791; PubMed Central PMCID: PMC6003328.

15: Lee S, Won M, Hwang RH, Hur GM, Ro H. An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness. J Vis Exp. 2018 May 7;(135). doi: 10.3791/57494. PubMed PMID: 29781995.

16: Wulff JP, Capriotti N, Ons S. Orcokinins regulate the expression of neuropeptide precursor genes related to ecdysis in the hemimetabolous insect Rhodnius prolixus. J Insect Physiol. 2018 Jul;108:31-39. doi: 10.1016/j.jinsphys.2018.05.006. Epub 2018 May 17. PubMed PMID: 29778903.

17: Gontijo AM, Garelli A. The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. Mech Dev. 2018 Apr 30. pii: S0925-4773(18)30072-8. doi: 10.1016/j.mod.2018.04.005. [Epub ahead of print] Review. PubMed PMID: 29715504.

18: Xu K, Liu X, Wang Y, Wong C, Song Y. Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming. Elife. 2018 May 1;7. pii: e33934. doi: 10.7554/eLife.33934. PubMed PMID: 29714689; PubMed Central PMCID: PMC5986271.

19: Riddiford LM, Truman JW, Nern A. Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe of Drosophila melanogaster. Biol Open. 2018 Apr 23;7(4). pii: bio034025. doi: 10.1242/bio.034025. PubMed PMID: 29618455; PubMed Central PMCID: PMC5936066.

20: Shen G, Wu J, Han C, Liu H, Xu Y, Zhang H, Lin Y, Xia Q. Oestrogen-related receptor reduces vitellogenin expression by crosstalk with the ecdysone receptor pathway in female silkworm, Bombyx mori. Insect Mol Biol. 2018 Mar 30. doi: 10.1111/imb.12385. [Epub ahead of print] PubMed PMID: 29603466.

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