Salmfamide 1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597805

CAS#: 134439-73-9

Description: Salmfamide 1 is a neuropeptide.


Chemical Structure

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Salmfamide 1
CAS# 134439-73-9

Theoretical Analysis

MedKoo Cat#: 597805
Name: Salmfamide 1
CAS#: 134439-73-9
Chemical Formula: C41H60N10O10S
Exact Mass: 884.4215
Molecular Weight: 885.05
Elemental Analysis: C, 55.64; H, 6.83; N, 15.83; O, 18.08; S, 3.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Salmfamide 1; Gfnsalmfamide; Neuropeptide S1;

IUPAC/Chemical Name: (S)-N1-((5S,8S,11S,14S)-5-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-hydroxy-8-isobutyl-11-methyl-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)-2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)succinamide

InChi Key: GACIWVVFDFGCKF-VDXNIVNJSA-N

InChi Code: InChI=1S/C41H60N10O10S/c1-23(2)17-29(38(58)47-27(15-16-62-4)37(57)48-28(35(44)55)18-25-11-7-5-8-12-25)49-36(56)24(3)45-41(61)32(22-52)51-40(60)31(20-33(43)53)50-39(59)30(46-34(54)21-42)19-26-13-9-6-10-14-26/h5-14,23-24,27-32,52H,15-22,42H2,1-4H3,(H2,43,53)(H2,44,55)(H,45,61)(H,46,54)(H,47,58)(H,48,57)(H,49,56)(H,50,59)(H,51,60)/t24-,27-,28-,29-,30-,31-,32-/m0/s1

SMILES Code: C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)Cc1ccccc1)=O)CC(N)=O)=O)CO)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)Cc2ccccc2)=O)CCSC)=O)CC(C)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 885.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Elphick MR, Reeve JR Jr, Burke RD, Thorndyke MC. Isolation of the neuropeptide SALMFamide-1 from starfish using a new antiserum. Peptides. 1991 May-Jun;12(3):455-9. PubMed PMID: 1923925.

2: Mita M, Oka H, Thorndyke MC, Shibata Y, Yoshikuni M, Nagahama Y. Inhibitory effect of a SALMFamide neuropeptide on secretion of gonad-stimulating substance from radial nerves in the starfish Asterina pectinifera. Zoolog Sci. 2004 Mar;21(3):299-303. PubMed PMID: 15056924.

3: Otara CB, Jones CE, Younan ND, Viles JH, Elphick MR. Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association. Biochim Biophys Acta. 2014 Feb;1844(2):358-65. doi: 10.1016/j.bbapap.2013.10.013. Epub 2013 Nov 5. PubMed PMID: 24200677.

4: Moore SJ, Thorndyke MC. Immunocytochemical mapping of the novel echinoderm neuropeptide SALMFamide 1 (S1) in the starfish Asterias rubens. Cell Tissue Res. 1993 Dec;274(3):605-18. PubMed PMID: 8293452.

5: Yun SS, Thorndyke MC, Elphick MR. Identification of novel SALMFamide neuropeptides in the starfish Marthasterias glacialis. Comp Biochem Physiol A Mol Integr Physiol. 2007 Jun;147(2):536-42. Epub 2007 Feb 9. PubMed PMID: 17337223.

6: Elphick MR, Melarange R. Neural control of muscle relaxation in echinoderms. J Exp Biol. 2001 Mar;204(Pt 5):875-85. Review. PubMed PMID: 11171411.

7: Melarange R, Elphick MR. Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish. J Exp Biol. 2003 Mar;206(Pt 5):893-9. PubMed PMID: 12547944.

8: Brownlee DJ, Fairweather I, Thorndyke MC, Johnston CF. Cellular and subcellular localization of SALMFamide (S1)-like immunoreactivity within the central nervous system of the nematode Ascaris suum (Nematoda, Ascaroidea). Parasitol Res. 1996;82(2):149-56. PubMed PMID: 8825210.

9: Elphick MR, Thorndyke MC. Molecular characterisation of SALMFamide neuropeptides in sea urchins. J Exp Biol. 2005 Nov;208(Pt 22):4273-82. PubMed PMID: 16272250.

10: Bascal ZA, Montgomery A, Holden-Dye L, Williams RG, Thorndyke MC, Walker RJ. NADPH diaphorase activity in peptidergic neurones of the parasitic nematode, Ascaris suum. Parasitology. 1996 Jan;112 ( Pt 1):125-34. PubMed PMID: 8587795.

11: Yao Y, Su J, Zhang F, Lei Z. Effects of central and peripheral administration of neuropeptide s on the level of serum proinflammatory cytokines in pigs. Neuroimmunomodulation. 2014;21(1):45-51. doi: 10.1159/000355977. Epub 2013 Nov 9. PubMed PMID: 24216974.

12: Elphick MR. From gonadotropin-inhibitory hormone to SIFamides: are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes? Gen Comp Endocrinol. 2013 Nov 1;193:229-33. doi: 10.1016/j.ygcen.2013.08.009. Epub 2013 Aug 30. PubMed PMID: 23994034.

13: Beer AJ, Moss C, Thorndyke M. Development of serotonin-like and SALMFamide-like immunoreactivity in the nervous system of the sea urchin Psammechinus miliaris. Biol Bull. 2001 Jun;200(3):268-80. PubMed PMID: 11441970.

14: Newman SJ, Elphick MR, Thorndyke MC. Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish Asterias rubens using novel monoclonal and polyclonal antibodies. I. Nervous and locomotory systems. Proc Biol Sci. 1995 Jul 22;261(1360):139-45. PubMed PMID: 7644545.

15: Brownlee DJ, Thorndyke MC, Fairweather I, Johnston CF. Immunocytochemical demonstration of SALMFamide(S1)-like immunoreactivity in the nervous system of two marine platyhelminth parasites, Diclidophora merlangi and Grillotia erinaceus. Acta Biol Hung. 1995;46(2-4):205-9. PubMed PMID: 8853690.

16: Elphick MR. The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus. PLoS One. 2012;7(8):e44492. doi: 10.1371/journal.pone.0044492. Epub 2012 Aug 31. PubMed PMID: 22952987; PubMed Central PMCID: PMC3432112.

17: Elphick MR, Price DA, Lee TD, Thorndyke MC. The SALMFamides: a new family of neuropeptides isolated from an echinoderm. Proc Biol Sci. 1991 Feb 22;243(1307):121-7. PubMed PMID: 1676515.

18: Brownlee DJ, Fairweather I, Johnston CF, Thorndyke MC, Skuce PJ. Immunocytochemical demonstration of a SALMFamide-like neuropeptide in the nervous system of adult and larval stages of the human blood fluke, Schistosoma mansoni. Parasitology. 1995 Feb;110 ( Pt 2):143-53. PubMed PMID: 7885733.

19: Ghyoot M, Cobb JL, Thorndyke MC. Localization of neuropeptides in the nervous system of the brittle star Ophiura ophiura. Philos Trans R Soc Lond B Biol Sci. 1994 Dec 29;346(1318):433-44. PubMed PMID: 7746846.

20: Meis S, Bergado-Acosta JR, Yanagawa Y, Obata K, Stork O, Munsch T. Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus. PLoS One. 2008 Jul 16;3(7):e2695. doi: 10.1371/journal.pone.0002695. PubMed PMID: 18628994; PubMed Central PMCID: PMC2442874.