WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558399

CAS#: 1395048-49-3

Description: M-110 is a inhibitor of protein arginine N-methyltransferases (PRMTs). It is also a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3, shown to inhibit the proliferation of prostate cancer cell lines with IC50s between 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.

Chemical Structure

CAS# 1395048-49-3

Theoretical Analysis

MedKoo Cat#: 558399
Name: M-110
CAS#: 1395048-49-3
Chemical Formula: C22H28ClN5O3
Exact Mass: 445.19
Molecular Weight: 445.95
Elemental Analysis: C, 59.25; H, 6.33; Cl, 7.95; N, 15.70; O, 10.76

Price and Availability

Size Price Availability Quantity
5.0mg USD 270.0 2 Weeks
25.0mg USD 460.0 2 Weeks
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Synonym: M-110; M 110; M110;

IUPAC/Chemical Name: (E)-2-(3-Morpholin-4-yl-propylamino)-isonicotinic acid [1-(4-chloro-2-hydroxy-phenyl)-propylidene]-hydrazide


InChi Code: InChI=1S/C22H28ClN5O3/c1-2-19(18-5-4-17(23)15-20(18)29)26-27-22(30)16-6-8-25-21(14-16)24-7-3-9-28-10-12-31-13-11-28/h4-6,8,14-15,29H,2-3,7,9-13H2,1H3,(H,24,25)(H,27,30)/b26-19+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 445.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gailly P, Wu X, Haystead TA, Somlyo AP, Cohen PT, Cohen P, Somlyo AV. Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. Eur J Biochem. 1996 Jul 15;239(2):326-32. PubMed PMID: 8706736.

2: Johnson D, Cohen P, Chen MX, Chen YH, Cohen PT. Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin. Eur J Biochem. 1997 Mar 15;244(3):931-9. PubMed PMID: 9108268.

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4: Calhoun MW, Lemieux LJ, Garcia-Horsman JA, Thomas JW, Alben JO, Gennis RB. The highly conserved methionine of subunit I of the heme-copper oxidases is not at the heme-copper dinuclear center: mutagenesis of M110 in subunit I of cytochrome bo3-type ubiquinol oxidase from Escherichia coli. FEBS Lett. 1995 Jul 24;368(3):523-5. PubMed PMID: 7635213.

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8: Lee BY, Ahn MH, Kim HC, Min DY. Toxoplasma gondii: ultrastructural localization of specific antigens and inhibition of intracellular multiplication by monoclonal antibodies. Korean J Parasitol. 2001 Mar;39(1):67-75. PubMed PMID: 11301592; PubMed Central PMCID: PMC2721067.

9: Katoh M, Djiane J, Kelly PA. Monoclonal antibodies against rabbit mammary prolactin receptors. Specific antibodies to the hormone binding domain. J Biol Chem. 1985 Sep 25;260(21):11422-9. PubMed PMID: 2995333.

10: Guo LT, Helgadóttir S, Söll D, Ling J. Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor. Nucleic Acids Res. 2012 Sep;40(16):7967-74. doi: 10.1093/nar/gks507. Epub 2012 May 31. PubMed PMID: 22661575; PubMed Central PMCID: PMC3439900.

11: Sands NB, Adamson PA. Nasal tip deprojection with crural cartilage overlap: the M-arch model. Facial Plast Surg Clin North Am. 2015 Feb;23(1):93-104. doi: 10.1016/j.fsc.2014.09.007. Review. PubMed PMID: 25430931.

12: Dvir H, Lundberg ME, Maji SK, Riek R, Choe S. Mistic: cellular localization, solution behavior, polymerization, and fibril formation. Protein Sci. 2009 Jul;18(7):1564-70. doi: 10.1002/pro.148. PubMed PMID: 19475664; PubMed Central PMCID: PMC2775223.

13: Jenny C. A possible mechanism for accidental humeral fractures in infants. Pediatr Radiol. 2014 Oct;44(10):1218. doi: 10.1007/s00247-014-3098-6. Epub 2014 Aug 2. PubMed PMID: 25085440.

14: Sands NB, Adamson PA. Pediatric esthetic otoplasty. Facial Plast Surg Clin North Am. 2014 Nov;22(4):611-21. doi: 10.1016/j.fsc.2014.07.008. Epub 2014 Nov 8. Review. PubMed PMID: 25444732.

15: Chen YH, Chen MX, Alessi DR, Campbell DG, Shanahan C, Cohen P, Cohen PT. Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. FEBS Lett. 1994 Dec 12;356(1):51-5. PubMed PMID: 7988720.

16: Yuan H, Amin R, Ye X, de la Motte CA, Cowman MK. Determination of hyaluronan molecular mass distribution in human breast milk. Anal Biochem. 2015 Apr 1;474:78-88. doi: 10.1016/j.ab.2014.12.020. Epub 2015 Jan 9. PubMed PMID: 25579786; PubMed Central PMCID: PMC4357551.

17: MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. FEBS Lett. 2001 Mar 30;493(2-3):91-4. PubMed PMID: 11287002.

18: Dong J, Ren L, Zhang Y, Cui X, Hu P, Xu J. Direct electrodeposition of cable-like CuO@Cu nanowires array for non-enzymatic sensing. Talanta. 2015 Jan;132:719-26. doi: 10.1016/j.talanta.2014.10.027. Epub 2014 Oct 22. PubMed PMID: 25476370.

19: Assah F, Mbanya JC, Ekelund U, Wareham N, Brage S. Patterns and correlates of objectively measured free-living physical activity in adults in rural and urban Cameroon. J Epidemiol Community Health. 2015 Jul;69(7):700-7. doi: 10.1136/jech-2014-205154. Epub 2015 Apr 3. PubMed PMID: 25841243; PubMed Central PMCID: PMC4484252.

20: Adamson PA, Constantinides M, Kim AJ, Pearlman S. Rhinoplasty: panel discussion. Facial Plast Surg Clin North Am. 2014 Feb;22(1):25-55. doi: 10.1016/j.fsc.2013.09.001. Review. PubMed PMID: 24290994.


5.0mg / USD 270.0