NCFP

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MedKoo CAT#: 563263

CAS#: 774548-65-1

Description: NCFP is an efficacious mGlu5 PAM. It acts by providing greater mGlu5 subtype selectivity than CPPHA.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NCFP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563263
Name: NCFP
CAS#: 774548-65-1
Chemical Formula: C21H13ClFN3O3
Exact Mass: 409.0629
Molecular Weight: 409.8
Elemental Analysis: C, 61.55; H, 3.20; Cl, 8.65; F, 4.64; N, 10.25; O, 11.71


Synonym: NCFP;

IUPAC/Chemical Name: N-(4-chloro-2-((4-fluoro-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide

InChi Key: WBXKMHFMMCOTOK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H13ClFN3O3/c22-13-7-8-16(25-19(27)17-6-1-2-9-24-17)12(10-13)11-26-20(28)14-4-3-5-15(23)18(14)21(26)29/h1-10H,11H2,(H,25,27)

SMILES Code: O=C(NC1=CC=C(Cl)C=C1CN(C(C2=C3C=CC=C2F)=O)C3=O)C4=NC=CC=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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2: Brito A, Olivares M, Pizarro T, Rodríguez L, Hertrampf E. Chilean complementary feeding program reduces anemia and improves iron status in children aged 11 to 18 months. Food Nutr Bull. 2013 Dec;34(4):378-85. PubMed PMID: 24605687.

3: Baer RA, Killen JP, Cho Y, Mantha M. Non-candidal fungal peritonitis in Far North Queensland: a case series. Perit Dial Int. 2013 Sep-Oct;33(5):559-64. doi: 10.3747/pdi.2012.00024. Epub 2013 Jul 1. PubMed PMID: 23818003; PubMed Central PMCID: PMC3797675.

4: Brito A, Hertrampf E, Olivares M. Iron status biomarkers and C-reactive protein in children aged 19 to 72 months in Chile. Food Nutr Bull. 2013 Mar;34(1):14-20. PubMed PMID: 23767277.

5: Brito A, Hertrampf E, Olivares M. Low prevalence of anemia in children aged 19 to 72 months in Chile. Food Nutr Bull. 2012 Dec;33(4):308-11. PubMed PMID: 23424897.

6: Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn PJ. A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol Pharmacol. 2013 Apr;83(4):835-47. doi: 10.1124/mol.112.082891. Epub 2013 Jan 24. Erratum in: Mol Pharmacol. 2013 Oct;84(4):654. PubMed PMID: 23348500; PubMed Central PMCID: PMC3608436.

7: Denisova DV, Nikitin IuP, Zav'ialova LG, Burakova SV, Ivanova MV. [Secular trends in blood lipid disorders among adolescents: population study in Novosibirsk (1989-2003)]. Kardiologiia. 2007;47(6):62-7. Russian. PubMed PMID: 18260880.

8: Maeda H, Osuka A, Furuta H. Trans doubly N-confused porphyrins: Cu(III) complexation and formation of rodlike hydrogen-bonding networks. J Am Chem Soc. 2003 Dec 24;125(51):15690-1. PubMed PMID: 14677928.

9: Dias LA, Kageyama PY. Combining-ability for cacao (Theobroma cacao L.) yield components under southern Bahia conditions. Theor Appl Genet. 1995 Mar;90(3-4):534-41. doi: 10.1007/BF00222000. PubMed PMID: 24173948.