Norchlorcyclizine
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MedKoo CAT#: 563255

CAS#: 303-26-4

Description: Norchlorcyclizine is a partially selective NPR-B inhibitor. It also acts as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1).


Chemical Structure

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Norchlorcyclizine
CAS# 303-26-4

Theoretical Analysis

MedKoo Cat#: 563255
Name: Norchlorcyclizine
CAS#: 303-26-4
Chemical Formula: C17H19ClN2
Exact Mass: 286.12
Molecular Weight: 286.803
Elemental Analysis: C, 71.19; H, 6.68; Cl, 12.36; N, 9.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Norchlorcyclizine; C10; C-10; C 10;

IUPAC/Chemical Name: 1-((4-chlorophenyl)(phenyl)methyl)piperazine

InChi Key: UZKBSZSTDQSMDR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2

SMILES Code: ClC1=CC=C(C(N2CCNCC2)C3=CC=CC=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Biological target: Norchlorcyclizine is a partially selective NPR-B inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 104.60
DMSO 30.0 104.60
DMSO:PBS (pH 7.2) (1:4) 0.2 0.70
Ethanol 25.0 87.17

Preparing Stock Solutions

The following data is based on the product molecular weight 286.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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6: Kamm JJ, Szuna A, Kuntzman R. Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat. J Pharmacol Exp Ther. 1972 Sep;182(3):507-14. PubMed PMID: 4403434.

7: Wilk AL, Steffek AJ, King CT. Norchlorcyclizine analogs: relationship of teratogenic activity to in vitro cartilage binding. J Pharmacol Exp Ther. 1970 Jan;171(1):118-26. PubMed PMID: 4391467.

8: Wilk AL. Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application. Teratology. 1969 Feb;2(1):55-65. PubMed PMID: 4389241.

9: Kuntzman R, Tsai I, Burns JJ. Importance of tissue and plasma binding in determining the retention of norchlorcyclizine and norcyclizine in man, dog and rat. J Pharmacol Exp Ther. 1967 Nov;158(2):332-9. PubMed PMID: 4383640.