WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 559186
Description: L 363564 is a kidney renin inhibitor.
MedKoo Cat#: 559186
Name: L 363564
Chemical Formula: C54H76N12O10
Exact Mass: 1052.5807
Molecular Weight: 1053.27
Elemental Analysis: C, 61.58; H, 7.27; N, 15.96; O, 15.19
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: L 363564; L-363564; L363564; L-363,564; L 363,564; L363,564; Boc-his-pro-phe-his-statine-leu-phe-NH2;
IUPAC/Chemical Name: tert-butyl (1-(2-((13-((1H-imidazol-5-yl)methyl)-1-amino-2-benzyl-9-hydroxy-5,10-diisobutyl-1,4,7,12,15-pentaoxo-17-phenyl-3,6,11,14-tetraazaheptadecan-16-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)carbamate
InChi Key: LIAZNMWGUZOVRC-UHFFFAOYSA-N
InChi Code: 1S/C54H76N12O10/c1-32(2)21-38(45(67)27-46(68)60-40(22-33(3)4)48(70)62-39(47(55)69)23-34-15-10-8-11-16-34)61-50(72)42(25-36-28-56-30-58-36)63-49(71)41(24-35-17-12-9-13-18-35)64-51(73)44-19-14-20-66(44)52(74)43(26-37-29-57-31-59-37)65-53(75)76-54(5,6)7/h8-13,15-18,28-33,38-45,67H,14,19-27H2,1-7H3,(H2,55,69)(H,56,58)(H,57,59)(H,60,68)(H,61,72)(H,62,70)(H,63,71)(H,64,73)(H,65,75)
SMILES Code: CC(CC(NC(C(NC(C(NC(C1CCCN1C(C(NC(OC(C)(C)C)=O)Cc2[nH]cnc2)=O)=O)Cc3ccccc3)=O)Cc4[nH]cnc4)=O)C(O)CC(NC(C(NC(C(N)=O)Cc5ccccc5)=O)CC(C)C)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 1053.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature. 1987 May 28-Jun 3;327(6120):349-52. PubMed PMID: 3295561.