Neuropeptide DF2

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MedKoo CAT#: 597724

CAS#: 149471-11-4

Description: Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish, Procambarus clarkii.


Price and Availability

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Pricing updated 2020-10-29. Prices are subject to change without notice.

Neuropeptide DF2 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597724
Name: Neuropeptide DF2
CAS#: 149471-11-4
Chemical Formula: C44H67N15O10
Exact Mass: 965.5195
Molecular Weight: 966.11
Elemental Analysis: C, 54.70; H, 6.99; N, 21.75; O, 16.56


Synonym: Neuropeptide DF2; DF(2) Neuropeptide; Drnflrfamide;

IUPAC/Chemical Name: (6S,9S,12S,15S,18S,21S)-1,21-diamino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-(2-amino-2-oxoethyl)-12-benzyl-18-(3-guanidinopropyl)-1-imino-9-isobutyl-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatricosan-23-oic acid

InChi Key: DWSQPUHNGRSXSJ-MRNVWEPHSA-N

InChi Code: InChI=1S/C44H67N15O10/c1-24(2)19-31(40(67)55-29(16-10-18-53-44(50)51)38(65)56-30(36(47)63)20-25-11-5-3-6-12-25)57-41(68)32(21-26-13-7-4-8-14-26)58-42(69)33(23-34(46)60)59-39(66)28(15-9-17-52-43(48)49)54-37(64)27(45)22-35(61)62/h3-8,11-14,24,27-33H,9-10,15-23,45H2,1-2H3,(H2,46,60)(H2,47,63)(H,54,64)(H,55,67)(H,56,65)(H,57,68)(H,58,69)(H,59,66)(H,61,62)(H4,48,49,52)(H4,50,51,53)/t27-,28-,29-,30-,31-,32-,33-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Weiss T, Kreissl S, Rathmayer W. Localization of a FMRFamide-related peptide in efferent neurons and analysis of neuromuscular effects of DRNFLRFamide (DF2) in the crustacean Idotea emarginata. Eur J Neurosci. 2003 Jan;17(2):239-48. PubMed PMID: 12542660.

2: Friedrich RW, Quigley PA, Srivastava M, Skerrett M, Mercier AJ. Temperature dependence of synaptic modulation by a FMRFamide-related neuropeptide in crayfish. Neurosci Lett. 1994 Mar 14;169(1-2):56-8. PubMed PMID: 7914017.

3: Noronha KF, Mercier AJ. A role for calcium/calmodulin-dependent protein kinase in mediating synaptic modulation by a neuropeptide. Brain Res. 1995 Feb 27;673(1):70-4. PubMed PMID: 7757481.

4: Dunn TW, Mercier AJ. Synaptic modulation by a neuropeptide depends on temperature and extracellular calcium. J Neurophysiol. 2003 Apr;89(4):1807-14. PubMed PMID: 12686567.

5: Friedrich RW, Molnar GF, Schiebe M, Mercier AJ. Protein kinase C is required for long-lasting synaptic enhancement by the neuropeptide DRNFLRFamide in crayfish. J Neurophysiol. 1998 Feb;79(2):1127-31. PubMed PMID: 9463471.

6: Mercier AJ, Orchard I, TeBrugge V, Skerrett M. Isolation of two FMRFamide-related peptides from crayfish pericardial organs. Peptides. 1993 Mar-Apr;14(2):137-43. PubMed PMID: 8387183.

7: Mercier AJ, Lee J. Differential effects of neuropeptides on circular and longitudinal muscles of the crayfish hindgut. Peptides. 2002 Oct;23(10):1751-57. PubMed PMID: 12383862.

8: Rathmayer W, Djokaj S, Gaydukov A, Kreissl S. The neuromuscular junctions of the slow and the fast excitatory axon in the closer of the crab Eriphia spinifrons are endowed with different Ca2+ channel types and allow neuron-specific modulation of transmitter release by two neuropeptides. J Neurosci. 2002 Feb 1;22(3):708-17. PubMed PMID: 11826100.