Oxazepam hemisuccinate, (-)-

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MedKoo CAT#: 597702

CAS#: 68946-52-1

Description: Oxazepam hemisuccinate, (-)- is a [3H]adenosine binding in guinea-pig brain synaptosome inhibitor. Oxazepam hemisuccinate, (-)- is discontinued.

Chemical Structure

Oxazepam hemisuccinate, (-)-
CAS# 68946-52-1

Theoretical Analysis

MedKoo Cat#: 597702
Name: Oxazepam hemisuccinate, (-)-
CAS#: 68946-52-1
Chemical Formula: C19H15ClN2O5
Exact Mass: 386.0669
Molecular Weight: 386.78
Elemental Analysis: C, 59.00; H, 3.91; Cl, 9.17; N, 7.24; O, 20.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 4700-56-5 (racemic)  

Synonym: Oxazepam hemisuccinate, (-)-; (-)-Rv 1209; (R)-Oxazepam hemisuccinate; L-Oxazepam hemisuccinate;

IUPAC/Chemical Name: (R)-4-((7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)oxy)-4-oxobutanoic acid


InChi Code: InChI=1S/C19H15ClN2O5/c20-12-6-7-14-13(10-12)17(11-4-2-1-3-5-11)22-19(18(26)21-14)27-16(25)9-8-15(23)24/h1-7,10,19H,8-9H2,(H,21,26)(H,23,24)/t19-/m1/s1

SMILES Code: O=C(O[C@@H]1C(NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=N1)=O)CCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 386.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: DeLucia R. Inhibition of [3H]adenosine binding by stereoisomers of oxazepam hemisuccinate in guinea-pig brain synaptosomes. Gen Pharmacol. 1982;13(4):357-9. PubMed PMID: 7129076.

2: Babbini M, Torrielli MV. Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination. Curr Ther Res Clin Exp. 1972 Jun;14(6):311-23. PubMed PMID: 4403034.

3: de Angelis L, Predominato M, Vertua R. Stereostructure-activity relationships for oxazepam hemisuccinate. Effects on central nervous system. Arzneimittelforschung. 1972 Aug;22(8):1328-33. PubMed PMID: 4678394.

4: Traversa U, Newman M. Stereospecific influence of oxazepam hemisuccinate on cyclic AMP accumulation elicited by adenosine in cerebral cortical slices. Biochem Pharmacol. 1979 Aug 1;28(15):2363-5. PubMed PMID: 227409.

5: Zafiri O, Alessio-Vernì A, Mastroianni A, Marin LA. [A new benzodiazepine derivative, oxazepam hemisuccinate ester, in anesthesilogy and resuscitation]. Minerva Anestesiol. 1968 Nov;34(11):1285-94. Italian. PubMed PMID: 5715826.

6: Maksay G, Kardos J, Simonyi M, Tegyey Z, Otvös L. Specific binding of racemic oxazepam esters to rat brain synaptosomes and the influence of bioactivation by esterases. Arzneimittelforschung. 1981;31(6):979-81. PubMed PMID: 7196245.

7: Manzini G, Ciana A, Crescenzi V. The interaction of serum albumins with various drugs in aqueous solution. Gel permeation, calorimetric, and fluorescence data. Biophys Chem. 1979 Nov;10(3-4):389-96. PubMed PMID: 575298.

8: Domenici E, Bertucci C, Salvadori P, Wainer IW. Use of a human serum albumin-based high-performance liquid chromatography chiral stationary phase for the investigation of protein binding: detection of the allosteric interaction between warfarin and benzodiazepine binding sites. J Pharm Sci. 1991 Feb;80(2):164-6. PubMed PMID: 2051322.

9: Domenici E, Bertucci C, Salvadori P, Motellier S, Wainer IW. Immobilized serum albumin: rapid HPLC probe of stereoselective protein-binding interactions. Chirality. 1990;2(4):263-8. PubMed PMID: 2083149.