WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597702
CAS#: 68946-52-1
Description: Oxazepam hemisuccinate, (-)- is a [3H]adenosine binding in guinea-pig brain synaptosome inhibitor. Oxazepam hemisuccinate, (-)- is discontinued.
MedKoo Cat#: 597702
Name: Oxazepam hemisuccinate, (-)-
CAS#: 68946-52-1
Chemical Formula: C19H15ClN2O5
Exact Mass: 386.0669
Molecular Weight: 386.78
Elemental Analysis: C, 59.00; H, 3.91; Cl, 9.17; N, 7.24; O, 20.68
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 4700-56-5 (racemic)
Synonym: Oxazepam hemisuccinate, (-)-; (-)-Rv 1209; (R)-Oxazepam hemisuccinate; L-Oxazepam hemisuccinate;
IUPAC/Chemical Name: (R)-4-((7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)oxy)-4-oxobutanoic acid
InChi Key: UCUOKZUJHTYPJT-LJQANCHMSA-N
InChi Code: InChI=1S/C19H15ClN2O5/c20-12-6-7-14-13(10-12)17(11-4-2-1-3-5-11)22-19(18(26)21-14)27-16(25)9-8-15(23)24/h1-7,10,19H,8-9H2,(H,21,26)(H,23,24)/t19-/m1/s1
SMILES Code: O=C(O[C@@H]1C(NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=N1)=O)CCC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 386.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: DeLucia R. Inhibition of [3H]adenosine binding by stereoisomers of oxazepam hemisuccinate in guinea-pig brain synaptosomes. Gen Pharmacol. 1982;13(4):357-9. PubMed PMID: 7129076.
2: Babbini M, Torrielli MV. Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination. Curr Ther Res Clin Exp. 1972 Jun;14(6):311-23. PubMed PMID: 4403034.
3: de Angelis L, Predominato M, Vertua R. Stereostructure-activity relationships for oxazepam hemisuccinate. Effects on central nervous system. Arzneimittelforschung. 1972 Aug;22(8):1328-33. PubMed PMID: 4678394.
4: Traversa U, Newman M. Stereospecific influence of oxazepam hemisuccinate on cyclic AMP accumulation elicited by adenosine in cerebral cortical slices. Biochem Pharmacol. 1979 Aug 1;28(15):2363-5. PubMed PMID: 227409.
5: Zafiri O, Alessio-Vernì A, Mastroianni A, Marin LA. [A new benzodiazepine derivative, oxazepam hemisuccinate ester, in anesthesilogy and resuscitation]. Minerva Anestesiol. 1968 Nov;34(11):1285-94. Italian. PubMed PMID: 5715826.
6: Maksay G, Kardos J, Simonyi M, Tegyey Z, Otvös L. Specific binding of racemic oxazepam esters to rat brain synaptosomes and the influence of bioactivation by esterases. Arzneimittelforschung. 1981;31(6):979-81. PubMed PMID: 7196245.
7: Manzini G, Ciana A, Crescenzi V. The interaction of serum albumins with various drugs in aqueous solution. Gel permeation, calorimetric, and fluorescence data. Biophys Chem. 1979 Nov;10(3-4):389-96. PubMed PMID: 575298.
8: Domenici E, Bertucci C, Salvadori P, Wainer IW. Use of a human serum albumin-based high-performance liquid chromatography chiral stationary phase for the investigation of protein binding: detection of the allosteric interaction between warfarin and benzodiazepine binding sites. J Pharm Sci. 1991 Feb;80(2):164-6. PubMed PMID: 2051322.
9: Domenici E, Bertucci C, Salvadori P, Motellier S, Wainer IW. Immobilized serum albumin: rapid HPLC probe of stereoselective protein-binding interactions. Chirality. 1990;2(4):263-8. PubMed PMID: 2083149.
