Oxazepam acetate, (-)-

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597701

CAS#: 68399-22-4

Description: Oxazepam acetate, (-)- is a centrally acting drug. Oxazepam acetate, (-)- is discontinued.


Chemical Structure

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Oxazepam acetate, (-)-
CAS# 68399-22-4

Theoretical Analysis

MedKoo Cat#: 597701
Name: Oxazepam acetate, (-)-
CAS#: 68399-22-4
Chemical Formula: C17H13ClN2O3
Exact Mass: 328.0615
Molecular Weight: 328.75
Elemental Analysis: C, 62.11; H, 3.99; Cl, 10.78; N, 8.52; O, 14.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Oxazepam acetate, (-)-; L-Oxazepam acetate; R-Oxazepam 3-acetate;

IUPAC/Chemical Name: (R)-7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl acetate

InChi Key: FYRWUTOZBRWYCS-QGZVFWFLSA-N

InChi Code: InChI=1S/C17H13ClN2O3/c1-10(21)23-17-16(22)19-14-8-7-12(18)9-13(14)15(20-17)11-5-3-2-4-6-11/h2-9,17H,1H3,(H,19,22)/t17-/m1/s1

SMILES Code: CC(O[C@@H]1C(NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=N1)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 328.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Maksay G, Tegyey Z, Otvös L. Stereospecificity of esterases hydrolyzing oxazepam acetate. J Pharm Sci. 1978 Sep;67(9):1208-10. PubMed PMID: 690821.

2: Yang SK, Lu XL. Racemization kinetics of enantiomeric oxazepams and stereoselective hydrolysis of enantiomeric oxazepam 3-acetates in rat liver microsomes and brain homogenate. J Pharm Sci. 1989 Oct;78(10):789-95. PubMed PMID: 2600781.

3: Fitos I, Tegyey Z, Simonyi M, Sjöholm I, Larsson T, Lagercrantz C. Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers. Biochem Pharmacol. 1986 Jan 15;35(2):263-9. PubMed PMID: 3942599.

4: Yang SK, Huang A, Huang JD. Enantioselectivity of esterases in human brain. Chirality. 1993;5(7):565-8. PubMed PMID: 8240930.

5: Yang SK, Chen SJ, Huang JD. Enantioselectivity suggests a cytosolic origin for a commercial pig liver esterase preparation. Chirality. 1995;7(1):40-3. PubMed PMID: 7702997.

6: Aso Y, Yoshioka S, Takeda Y. Epimerization and racemization of some chiral drugs in the presence of human serum albumin. Chem Pharm Bull (Tokyo). 1990 Jan;38(1):180-4. PubMed PMID: 2337941.

7: Simonyi M, Fitos I, Tegyey Z, Otvös L. Stationary ultrafiltration: a radio-tracer technique for studying stereoselective binding of racemic ligands. Biochem Biophys Res Commun. 1980 Nov 17;97(1):1-7. PubMed PMID: 7458928.

8: Chen J, Fitos I, Hage DS. Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin. Chirality. 2006 Jan;18(1):24-36. PubMed PMID: 16278829.

9: Simonyi M, Fitos I, Kajtár J, Kajtár M. Application of ultrafiltration and CD spectroscopy for studying stereoselective binding of racemic ligands. Biochem Biophys Res Commun. 1982 Dec 15;109(3):851-7. PubMed PMID: 6130765.