7ETMC

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558392

CAS#: 1370702-83-2

Description: 7ETMC is a selective Inhibitor of Human Cytochrome P450s 1A1 and 1A2. 7ETMC showed IC(50) values of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450s 2A6 and 2B1 even at the dose of 50 μM.


Chemical Structure

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7ETMC
CAS# 1370702-83-2

Theoretical Analysis

MedKoo Cat#: 558392
Name: 7ETMC
CAS#: 1370702-83-2
Chemical Formula: C14H12O2
Exact Mass: 212.08
Molecular Weight: 212.25
Elemental Analysis: C, 79.23; H, 5.70; O, 15.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 7ETMC; 7-ETMC; 7 ETMC;

IUPAC/Chemical Name: 7-Ethynyl-3,4,8-trimethylcoumarin

InChi Key: LZVDYIJEUWVNGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12O2/c1-5-11-6-7-12-8(2)9(3)14(15)16-13(12)10(11)4/h1,6-7H,2-4H3

SMILES Code: O=C1OC2=C(C=CC(C#C)=C2C)C(C)=C1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 212.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu J, Nguyen TT, Dupart PS, Sridhar J, Zhang X, Zhu N, Stevens CL, Foroozesh
M. 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and
1A2. Chem Res Toxicol. 2012 May 21;25(5):1047-57. doi: 10.1021/tx300023p. Epub
2012 Apr 10. PubMed PMID: 22443586; PubMed Central PMCID: PMC3358478.