N(G)-Nitroarginine-4-nitroanilide
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MedKoo CAT#: 597647

CAS#: 85697-89-8

Description: N(G)-Nitroarginine-4-nitroanilide is an anti-nociceptive agent in the mouse.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 220 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

N(G)-Nitroarginine-4-nitroanilide purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597647
Name: N(G)-Nitroarginine-4-nitroanilide
CAS#: 85697-89-8
Chemical Formula: C12H17N7O5
Exact Mass: 339.1291
Molecular Weight: 339.31
Elemental Analysis: C, 42.48; H, 5.05; N, 28.90; O, 23.58


Synonym: N(G)-Nitroarginine-4-nitroanilide; N(omega)-Nitro-L-arginine p-nitroanilide; NAPNA; L-Napna;

IUPAC/Chemical Name: (S)-2-amino-5-(3-nitroguanidino)-N-(4-nitrophenyl)pentanamide

InChi Key: LNWGWFVAPQTGMG-JTQLQIEISA-N

InChi Code: InChI=1S/C12H17N7O5/c13-10(2-1-7-15-12(14)17-19(23)24)11(20)16-8-3-5-9(6-4-8)18(21)22/h3-6,10H,1-2,7,13H2,(H,16,20)(H3,14,15,17)/t10-/m0/s1

SMILES Code: O=[N+]([O-])NC(NCCC[C@H](N)C(Nc1ccc([N+]([O-])=O)cc1)=O)=N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Babbedge RC, Wallace P, Gaffen ZA, Hart SL, Moore PK. L-NG-nitro arginine p-nitroanilide (L-NAPNA) is anti-nociceptive in the mouse. Neuroreport. 1993 Mar;4(3):307-10. PubMed PMID: 7682856.

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3: Vroom MB, Pfaffendorf M, van Wezel HB, van Zwieten PA. Effect of phosphodiesterase inhibitors on human arteries in vitro. Br J Anaesth. 1996 Jan;76(1):122-9. PubMed PMID: 8672353.

4: Rice AS. Topical spinal administration of a nitric oxide synthase inhibitor prevents the hyper-reflexia associated with a rat model of persistent visceral pain. Neurosci Lett. 1995 Mar 3;187(2):111-4. PubMed PMID: 7540269.

5: Riazimand SH, Mense S. Interaction between neurotransmitter antagonists and effects of sacral neuromodulation in rats with chronically hyperactive bladder. BJU Int. 2005 Oct;96(6):900-8. PubMed PMID: 16153226.

6: Burlet S, Cespuglio R. Voltammetric detection of nitric oxide (NO) in the rat brain: its variations throughout the sleep-wake cycle. Neurosci Lett. 1997 Apr 25;226(2):131-5. PubMed PMID: 9159507.

7: Lhuillier F, Robert MO, Crova P, Goudable J, Arnal F, Cespuglio R, Annat G, Viale JP. Nitric oxide and liver microcirculation during autoregulation and haemorrhagic shock in rabbit model. Br J Anaesth. 2006 Aug;97(2):137-46. Epub 2006 Apr 13. PubMed PMID: 16613926.

8: Desvignes C, Robert F, Vachette C, Chouvet G, Cespuglio R, Renaud B, Lambás-Señas L. Monitoring nitric oxide (NO) in rat locus coeruleus: differential effects of NO synthase inhibitors. Neuroreport. 1997 Apr 14;8(6):1321-5. PubMed PMID: 9172128.

9: Matthew JD, Wadsworth RM. The role of nitric oxide in inhibitory neurotransmission in the middle cerebral artery of the sheep. Gen Pharmacol. 1997 Mar;28(3):393-7. PubMed PMID: 9068979.

10: Su JB, Hoüel R, Héloire F, Barbe F, Beverelli F, Sambin L, Castaigne A, Berdeaux A, Crozatier B, Hittinger L. Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B(2) receptor stimulation. Circulation. 2000 Apr 18;101(15):1848-53. PubMed PMID: 10769287.

11: Hars B. Endogenous nitric oxide in the rat pons promotes sleep. Brain Res. 1999 Jan 16;816(1):209-19. PubMed PMID: 9878741.

12: Granjeiro EM, Machado BH. NO in the caudal NTS modulates the increase in respiratory frequency in response to chemoreflex activation in awake rats. Respir Physiol Neurobiol. 2009 Mar 31;166(1):32-40. doi: 10.1016/j.resp.2009.01.003. Epub 2009 Jan 22. PubMed PMID: 19371638.

13: Guo J, Lam LT, Longenecker KL, Bui MH, Idler KB, Glaser KB, Wilsbacher JL, Tse C, Pappano WN, Huang TH. Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD(+) biosynthesis pathway and NAMPT mutation. Biochem Biophys Res Commun. 2017 Sep 23;491(3):681-686. doi: 10.1016/j.bbrc.2017.07.143. Epub 2017 Jul 26. PubMed PMID: 28756225.