Neurokinin A-OH

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MedKoo CAT#: 597632

CAS#: 102989-34-4

Description: Neurokinin A-OH is the C-terminal free acid derivative of neurokinin A.


Price and Availability

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Pricing updated 2020-10-30. Prices are subject to change without notice.

Neurokinin A-OH is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597632
Name: Neurokinin A-OH
CAS#: 102989-34-4
Chemical Formula: C50H79N13O15S
Exact Mass: 1133.5539
Molecular Weight: 1134.31
Elemental Analysis: C, 52.94; H, 7.02; N, 16.05; O, 21.16; S, 2.83


Synonym: Neurokinin A-OH; Nka-OH; NkaOH; Nka OH;

IUPAC/Chemical Name: (2S,5S,11S,14S,17S,20S)-20-((2S,3R)-2-((S)-6-amino-2-((S)-2-amino-3-(1H-imidazol-4-yl)propanamido)hexanamido)-3-hydroxybutanamido)-14-benzyl-17-(hydroxymethyl)-5-isobutyl-11-isopropyl-2-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid

InChi Key: CHLXODSFZFRYJS-JPQUDPSNSA-N

InChi Code: InChI=1S/C50H79N13O15S/c1-26(2)18-34(44(71)58-33(50(77)78)15-17-79-6)56-38(66)23-54-48(75)40(27(3)4)62-46(73)35(19-29-12-8-7-9-13-29)59-47(74)37(24-64)61-45(72)36(21-39(67)68)60-49(76)41(28(5)65)63-43(70)32(14-10-11-16-51)57-42(69)31(52)20-30-22-53-25-55-30/h7-9,12-13,22,25-28,31-37,40-41,64-65H,10-11,14-21,23-24,51-52H2,1-6H3,(H,53,55)(H,54,75)(H,56,66)(H,57,69)(H,58,71)(H,59,74)(H,60,76)(H,61,72)(H,62,73)(H,63,70)(H,67,68)(H,77,78)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1

SMILES Code: CSCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCCCN)NC([C@H](CC2=CNC=N2)N)=O)=O)=O)=O)=O)=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Patacchini R, Quartara L, Rovero P, Goso C, Maggi CA. Role of C-terminal amidation on the biological activity of neurokinin A derivatives with agonist and antagonist properties. J Pharmacol Exp Ther. 1993 Jan;264(1):17-21. PubMed PMID: 8380857.