Acth (1-4)

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MedKoo CAT#: 597619

CAS#: 19405-50-6

Description: Acth (1-4) is the N-terminal tetrapeptide of ACTH.

Chemical Structure

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Acth (1-4)
CAS# 19405-50-6
Instruction

Theoretical Analysis

MedKoo Cat#: 597619
Name: Acth (1-4)
CAS#: 19405-50-6
Chemical Formula: C20H30N4O8S
Exact Mass: 486.18
Molecular Weight: 486.540
Elemental Analysis: C, 49.37; H, 6.22; N, 11.52; O, 26.31; S, 6.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Acth (1-4); (1-4) Corticotropin;

IUPAC/Chemical Name: L-seryl-L-tyrosyl-L-seryl-L-methionine

InChi Key: GTYVWTFUSMUWHM-VGWMRTNUSA-N

InChi Code: InChI=1S/C20H30N4O8S/c1-33-7-6-14(20(31)32)22-19(30)16(10-26)24-18(29)15(23-17(28)13(21)9-25)8-11-2-4-12(27)5-3-11/h2-5,13-16,25-27H,6-10,21H2,1H3,(H,22,30)(H,23,28)(H,24,29)(H,31,32)/t13-,14-,15-,16-/m0/s1

SMILES Code: CSCC[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CO)N)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 486.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: De Graan PN, Spruijt BM, Eberle AN, Girard J, Gispen WH. ACTH1-4 potentiates alpha-MSH-induced melanophore dispersion and excessive grooming. Peptides. 1986 Jan-Feb;7(1):1-4. PubMed PMID: 3012487.

2: Volosin M, Cancela L, Molina V. Influence of adrenocorticotrophic hormone on the behaviour in the swim test of rats treated chronically with desipramine. J Pharm Pharmacol. 1988 Jan;40(1):74-6. PubMed PMID: 2896786.

3: Neidle A, Reith ME. The degradation of adrenocorticotrophic hormone-(1-4) by mouse brain cytosol. Arch Biochem Biophys. 1980 Aug;203(1):288-95. PubMed PMID: 6250487.

4: Miller LJ, Moore FL. Intracranial administration of corticotropin-like peptides increases incidence of amphibian reproductive behavior. Peptides. 1983 Sep-Oct;4(5):729-33. PubMed PMID: 6318203.

5: Cehovic G, Cassonnet P. [Action of small peptides, fragments of ACTH on the incorporation of P32 in brain proteins in vitro]. C R Acad Sci III. 1984;298(7):191-4. French. PubMed PMID: 6324969.

6: Meyer ME, Bohus B. The modulation of the dorsal immobility response in the adult male Wistar rat: the opposite effects of ACTH4-10 and [D-Phe7]ACTH4-10. Behav Neural Biol. 1983 Jul;38(2):194-204. PubMed PMID: 6314984.

7: Gomar MD, Fernández B, Del Aguila CM, Castillo JL, Escames G, Acuña-Castroviejo D. Participation of ACTH1-10 and ACTH4-10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex. Experientia. 1995 Mar 15;51(3):209-12. PubMed PMID: 7698280.

8: Wan R, Diamant M, de Jong W, de Wied D. Differential effects of ACTH4-10, DG-AVP, and DG-OXT on heart rate and passive avoidance behavior in rats. Physiol Behav. 1992 Mar;51(3):507-13. PubMed PMID: 1326112.