Neurokinin K
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MedKoo CAT#: 597611

CAS#: 86933-75-7

Description: Neurokinin K is a mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 370 2 Weeks
5mg USD 1110 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

Neurokinin K purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597611
Name: Neurokinin K
CAS#: 86933-75-7
Chemical Formula: C55H79N13O14S2
Exact Mass: 1209.5311
Molecular Weight: 1210.43
Elemental Analysis: C, 54.58; H, 6.58; N, 15.04; O, 18.50; S, 5.30


Synonym: Neurokinin K; Neurokinin B; Neurokinin beta;

IUPAC/Chemical Name: (5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidazol-4-yl)methyl)-32-amino-17,20-dibenzyl-5-carbamoyl-23-(carboxymethyl)-8-isobutyl-14-isopropyl-29-(2-(methylthio)ethyl)-7,10,13,16,19,22,25,28,31-nonaoxo-2-thia-6,9,12,15,18,21,24,27,30-nonaazatetratriacontan-34-oic acid

InChi Key: NHXYSAFTNPANFK-HDMCBQFHSA-N

InChi Code: InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1

SMILES Code: CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(O)=O)NC([C@H](CC3=CNC=N3)NC([C@H](CCSC)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)=O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior. Physiol Behav. 1993 Aug;54(2):249-58. PubMed PMID: 7690487.

2: Sugino S, Farrag M, Ruiz-Velasco V. Gα14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. J Neurophysiol. 2016 Mar;115(3):1577-86. doi: 10.1152/jn.00980.2015. Epub 2016 Feb 3. PubMed PMID: 26843606; PubMed Central PMCID: PMC4808095.

3: Deacon CF, Agoston DV, Nau R, Conlon JM. Conversion of neuropeptide K to neurokinin A and vesicular colocalization of neurokinin A and substance P in neurons of the guinea pig small intestine. J Neurochem. 1987 Jan;48(1):141-6. PubMed PMID: 2432172.

4: Varnäs K, Finnema SJ, Stepanov V, Takano A, Tóth M, Svedberg M, Møller Nielsen S, Khanzhin NA, Juhl K, Bang-Andersen B, Halldin C, Farde L. Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628. Int J Neuropsychopharmacol. 2016 Aug 12;19(8). pii: pyw023. doi: 10.1093/ijnp/pyw023. Print 2016 Aug. PubMed PMID: 26993630; PubMed Central PMCID: PMC5006196.

5: Jansen I, Alafaci C, McCulloch J, Uddman R, Edvinsson L. Tachykinins (substance P, neurokinin A, neuropeptide K, and neurokinin B) in the cerebral circulation: vasomotor responses in vitro and in situ. J Cereb Blood Flow Metab. 1991 Jul;11(4):567-75. PubMed PMID: 1711051.

6: Chung BM, Stevens RC, Thomas CL, Palmere LN, Okazaki RK. Preliminary Report of a Neurokinin-Like Receptor Gene Sequence for the Nemertean Paranemertes sp. Zoolog Sci. 2015 Dec;32(6):567-70. doi: 10.2108/zs150081. PubMed PMID: 26654039.

7: Arai H, Emson PC. Regional distribution of neuropeptide K and other tachykinins (neurokinin A, neurokinin B and substance P) in rat central nervous system. Brain Res. 1986 Dec 10;399(2):240-9. PubMed PMID: 2435360.

8: George JT, Kakkar R, Marshall J, Scott ML, Finkelman RD, Ho TW, Veldhuis J, Skorupskaite K, Anderson RA, McIntosh S, Webber L. Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial. J Clin Endocrinol Metab. 2016 Nov;101(11):4313-4321. Epub 2016 Jul 26. PubMed PMID: 27459523.

9: Mazzocchi G, Malendowicz LK, Gottardo G, Nussdorfer GG. Neuropeptide K and neurokinin A stimulate CRH and ACTH release by rat adrenal medulla in vitro. Peptides. 1997;18(4):487-90. PubMed PMID: 9210165.

10: Conlon JM, Deacon CF, Richter G, Stöckmann F, Creutzfeldt W. Circulating tachykinins (substance P, neurokinin A, neuropeptide K) and the carcinoid flush. Scand J Gastroenterol. 1987 Jan;22(1):97-105. PubMed PMID: 2882598.

11: Gerard NP, Eddy RL Jr, Shows TB, Gerard C. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62. Erratum in: J Biol Chem. 1991 Jan 15;266(2):1354. PubMed PMID: 2173708.

12: Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA. Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women. J Clin Endocrinol Metab. 2016 Dec;101(12):4628-4636. Epub 2016 Sep 16. PubMed PMID: 27636018; PubMed Central PMCID: PMC5155690.

13: Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb;156(2):627-37. doi: 10.1210/en.2014-1651. Epub 2014 Nov 25. PubMed PMID: 25422875; PubMed Central PMCID: PMC4298326.

14: Martling CR, Theodorsson-Norheim E, Lundberg JM. Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways. Life Sci. 1987 Apr 20;40(16):1633-43. PubMed PMID: 2436021.

15: Martling CR, Theodorsson-Norheim E, Norheim I, Lundberg JM. Bronchoconstrictor and hypotensive effects in relation to pharmacokinetics of tachykinins in the guinea-pig--evidence for extraneuronal cleavage of neuropeptide K to neurokinin A. Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):183-9. PubMed PMID: 2825041.

16: Parchim NF, Wang W, Iriyama T, Ashimi OA, Siddiqui AH, Blackwell S, Sibai B, Kellems RE, Xia Y. Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia. Hypertension. 2015 Feb;65(2):430-9. doi: 10.1161/HYPERTENSIONAHA.114.04439. Epub 2014 Dec 1. PubMed PMID: 25452470; PubMed Central PMCID: PMC4736731.

17: Diez-Guerra FJ, Veira JA, Augood S, Emson PC. Ontogeny of the novel tachykinins neurokinin A, neurokinin B and neuropeptide K in the rat central nervous system. Regul Pept. 1989 Apr;25(1):87-97. PubMed PMID: 2541471.

18: Beding-Barnekow B, Brodin E. Neurokinin A, neurokinin B and neuropeptide K in the rabbit iris: a study comparing different extraction methods. Regul Pept. 1989 May;25(2):199-206. PubMed PMID: 2547226.

19: Too HP, Maggio JE. Immunocytochemical localization of neuromedin K (neurokinin B) in rat spinal ganglia and cord. Peptides. 1991 May-Jun;12(3):431-43. PubMed PMID: 1717951.

20: Theodorsson-Norheim E, Norheim I, Oberg K, Brodin E, Lundberg JM, Tatemoto K, Lindgren PG. Neuropeptide K: a major tachykinin in plasma and tumor tissues from carcinoid patients. Biochem Biophys Res Commun. 1985 Aug 30;131(1):77-83. PubMed PMID: 2412557.