NBP
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558386

CAS#: 6066-49-5

Description: NBP is an anti-apoptotic agent of bone marrow stem cells (BMSCs)


Price and Availability

Size Price Shipping out time Quantity
25mg USD 360 2 Weeks
100mg USD 900 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

NBP, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 558386
Name: NBP
CAS#: 6066-49-5
Chemical Formula: C12H14O2
Exact Mass: 190.1
Molecular Weight: 190.24
Elemental Analysis: C, 75.76; H, 7.42; O, 16.82


Synonym: NBP;

IUPAC/Chemical Name: dl-3-n-Butylphthalide

InChi Key: HJXMNVQARNZTEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3

SMILES Code: O=C1OC(CCCC)C2=C1C=CC=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Diao XX, Zhong K, Li XL, Zhong DF, Chen XY. Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier. Acta Pharmacol Sin. 2015 Dec;36(12):1520-7. doi: 10.1038/aps.2015.64. Epub 2015 Nov 16. PubMed PMID: 26567730; PubMed Central PMCID: PMC4816231.

2: Diao X, Pang X, Xie C, Guo Z, Zhong D, Chen X. Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. Drug Metab Dispos. 2014 Apr;42(4):774-81. doi: 10.1124/dmd.113.056218. Epub 2014 Jan 27. PubMed PMID: 24468743.

3: Zhang P, Guo ZF, Xu YM, Li YS, Song JG. N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway. Biomed Pharmacother. 2016 Oct;83:658-666. doi: 10.1016/j.biopha.2016.07.040. Epub 2016 Jul 26. PubMed PMID: 27468961.

4: Diao X, Ma Z, Wang H, Zhong D, Zhang Y, Jin J, Fan Y, Chen X. Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards. J Pharm Biomed Anal. 2013 May 5;78-79:19-26. doi: 10.1016/j.jpba.2013.01.033. Epub 2013 Feb 1. PubMed PMID: 23434525.

5: Diao X, Deng P, Xie C, Li X, Zhong D, Zhang Y, Chen X. Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Drug Metab Dispos. 2013 Feb;41(2):430-44. doi: 10.1124/dmd.112.049684. Epub 2012 Nov 20. PubMed PMID: 23169608.

6: Diao X, Ma Z, Lei P, Zhong D, Zhang Y, Chen X. Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 15;939:67-72. doi: 10.1016/j.jchromb.2013.09.014. Epub 2013 Sep 17. PubMed PMID: 24103433.

7: Wang HM, Zhang T, Huang JK, Sun XJ. 3-N-butylphthalide (NBP) attenuates the amyloid-β-induced inflammatory responses in cultured astrocytes via the nuclear factor-κB signaling pathway. Cell Physiol Biochem. 2013;32(1):235-42. doi: 10.1159/000350139. Epub 2013 Jul 26. PubMed PMID: 23899885.

8: Gómez-Bombarelli R, González-Pérez M, Calle E, Casado J. Potential of the NBP method for the study of alkylation mechanisms: NBP as a DNA-model. Chem Res Toxicol. 2012 Jun 18;25(6):1176-91. doi: 10.1021/tx300065v. Epub 2012 Apr 27. Review. Erratum in: Chem Res Toxicol. 2012 Aug 20;25(8):1787. PubMed PMID: 22480281.

9: Tanaka Y, Nagai Y, Dohdoh M, Oizumi T, Ohki A, Kuroishi T, Sugawara S, Endo Y. In vitro cytotoxicity of zoledronate (nitrogen-containing bisphosphonate: NBP) and/or etidronate (non-NBP) in tumour cells and periodontal cells. Arch Oral Biol. 2013 Jun;58(6):628-37. doi: 10.1016/j.archoralbio.2012.11.010. Epub 2012 Dec 12. PubMed PMID: 23245859.

10: Boggetti B, Jasik J, Takamiya M, Strähle U, Reugels AM, Campos-Ortega JA. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Dev Biol. 2012 May 1;365(1):164-74. doi: 10.1016/j.ydbio.2012.02.021. Epub 2012 Feb 22. PubMed PMID: 22387208.

11: Zhang T, Yan W, Li Q, Fu J, Liu K, Jia W, Sun X, Liu X. 3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia. Neurol Res. 2011 May;33(4):396-404. doi: 10.1179/1743132810Y.0000000006. PubMed PMID: 21535939.

12: Thinnes FP. Concerning a clue on the enigma of "amyloid made" versus "amyloid regulated" channels in cell membranes: a comment on M. A. Mukhamedyarov et al. NBP. 43: 479-484. 2013. Ross Fiziol Zh Im I M Sechenova. 2013 Aug;99(8):1002-4. PubMed PMID: 25470951.

13: Liu HW, Richard P, Zhao LX, Chen GF, Ding H. Comparative Raman study of Weyl semimetals TaAs, NbAs, TaP and NbP. J Phys Condens Matter. 2016 Jul 27;28(29):295401. doi: 10.1088/0953-8984/28/29/295401. Epub 2016 Jun 1. PubMed PMID: 27248581.

14: Yang LC, Li J, Xu SF, Cai J, Lei H, Liu DM, Zhang M, Rong XF, Cui DD, Wang L, Peng Y, Wang XL. L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats. CNS Neurosci Ther. 2015 Sep;21(9):733-41. doi: 10.1111/cns.12438. Epub 2015 Jul 28. PubMed PMID: 26215907.

15: Zhang T, Jia W, Sun X. 3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats. Neurol Res. 2010 May;32(4):390-6. doi: 10.1179/016164110X12670144526264. PubMed PMID: 20483006.

16: Ye J, Zhai L, Zhang S, Zhang Y, Chen L, Hu L, Zhang S, Ding Z. DL-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase. Platelets. 2015;26(8):736-44. doi: 10.3109/09537104.2014.989826. Epub 2015 Mar 3. PubMed PMID: 25734213.

17: Zhou Y, Niu LJ, Qi FM, Guo L. [Effect of 3-n-butylphthalide pretreatment on expression of the HSP70 after brain ischemia/reperfusion]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Mar;31(2):136-40. Chinese. PubMed PMID: 26248419.

18: Green J, Anjum MF, Guest JR. The ndh-binding protein (Nbp) regulates the ndh gene of Escherichia coli in response to growth phase and is identical to Fis. Mol Microbiol. 1996 Jun;20(5):1043-55. PubMed PMID: 8809757.

19: Zhao Q, Hu JP, Jiang J, Li Y, Hu P. [Interaction of butylphthalide with rat and human liver CYP450 isoenzymes]. Yao Xue Xue Bao. 2015 May;50(5):541-6. Chinese. PubMed PMID: 26234133.

20: Li J, Zhang S, Zhang L, Wang R, Wang M. Effects of L-3-n-butylphthalide on cognitive dysfunction and NR2B expression in hippocampus of streptozotocin (STZ)-induced diabetic rats. Cell Biochem Biophys. 2015 Jan;71(1):315-22. doi: 10.1007/s12013-014-0200-5. PubMed PMID: 25149651.