L-742001 Hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558372

CAS#: 174605-64-2

Description: L-742001 Hydrochloride is an inhibitor of RNA polymerase.


Chemical Structure

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L-742001 Hydrochloride
CAS# 174605-64-2

Theoretical Analysis

MedKoo Cat#: 558372
Name: L-742001 Hydrochloride
CAS#: 174605-64-2
Chemical Formula: C23H25Cl2NO4
Exact Mass: 449.12
Molecular Weight: 450.36
Elemental Analysis: C, 61.34; H, 5.60; Cl, 15.74; N, 3.11; O, 14.21

Price and Availability

Size Price Availability Quantity
5.0mg USD 290.0 2 Weeks
25.0mg USD 750.0 2 Weeks
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Related CAS #: 177592-42-6  

Synonym: L-742001; L 742001; L742001; L-742001 Hydrochloride; L 742001 Hydrochloride; L742001 Hydrochloride;

IUPAC/Chemical Name: 4-[4-[(4-Chlorophenyl)methyl]-1-(phenylmethyl)-4-piperidinyl]-2-hydroxy-4-oxo-2-butenoic acid Hydrochloride

InChi Key: LMLNSXCRZNNZBT-VSOKSMTPSA-N

InChi Code: InChI=1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-;

SMILES Code: O=C(O)/C(O)=C/C(C1(CC2=CC=C(Cl)C=C2)CCN(CC3=CC=CC=C3)CC1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 450.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yan Z, Zhang L, Fu H, Wang Z, Lin J. Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking. Bioorg Med Chem Lett. 2014 Jan 15;24(2):539-47. doi: 10.1016/j.bmcl.2013.12.026. Epub 2013 Dec 12. PubMed PMID: 24365156.