Carbarsone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592069

CAS#: 121-59-5

Description: Carbarsone is sometimes used in treatment of intestinal amoebiasis.


Chemical Structure

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Carbarsone
CAS# 121-59-5

Theoretical Analysis

MedKoo Cat#: 592069
Name: Carbarsone
CAS#: 121-59-5
Chemical Formula: C7H9AsN2O4
Exact Mass: 259.98
Molecular Weight: 259.080
Elemental Analysis: C, 32.33; H, 3.49; As, 28.81; N, 10.77; O, 24.61

Price and Availability

Size Price Availability Quantity
100mg USD 330
1g USD 1650
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Synonym: Carbarsone; NSC 32868; NSC-32868; NSC32868

IUPAC/Chemical Name: Arsanilic acid, N-carbamoyl-

InChi Key: WWXBHTZSYYGCSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)

SMILES Code: O[As](O)(C1=CC=C(NC(N)=O)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Peng D, Feng L, Pan Y, Wang Y, Chen D, Wang J, Yuan Z. Development and validation of an indirect competitive enzyme-linked immunosorbent assay for monitoring organoarsenic compounds in edible chicken and pork and feed. Food Chem. 2016 Apr 15;197(Pt A):821-8. doi: 10.1016/j.foodchem.2015.11.055. Epub 2015 Nov 14. PubMed PMID: 26617022.

2: Fisher DJ, Yonkos LT, Staver KW. Environmental concerns of roxarsone in broiler poultry feed and litter in Maryland, USA. Environ Sci Technol. 2015 Feb 17;49(4):1999-2012. doi: 10.1021/es504520w. Epub 2015 Feb 4. Review. PubMed PMID: 25608233.

3: P Mangalgiri K, Adak A, Blaney L. Organoarsenicals in poultry litter: detection, fate, and toxicity. Environ Int. 2015 Feb;75:68-80. doi: 10.1016/j.envint.2014.10.022. Epub 2014 Nov 15. Review. PubMed PMID: 25461415.

4: Nagata N, Marriott D, Harkness J, Ellis JT, Stark D. Current treatment options for Dientamoeba fragilis infections. Int J Parasitol Drugs Drug Resist. 2012 Sep 3;2:204-15. doi: 10.1016/j.ijpddr.2012.08.002. eCollection 2012 Dec. Review. PubMed PMID: 24533282; PubMed Central PMCID: PMC3862407.

5: Chen D, Zhang H, Tao Y, Wang Y, Huang L, Liu Z, Pan Y, Peng D, Wang X, Dai M, Yuan Z. Development of a high-performance liquid chromatography method for the simultaneous quantification of four organoarsenic compounds in the feeds of swine and chicken. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 1;879(11-12):716-20. doi: 10.1016/j.jchromb.2011.02.013. Epub 2011 Feb 13. PubMed PMID: 21388897.

6: Waibel PE, Halvorson JC, Noll SL, Hoffbeck SL, Daniels H. Influence of virginiamycin on growth and efficiency of large white turkeys. Poult Sci. 1991 Apr;70(4):837-47. PubMed PMID: 1908578.

7: Hellmann MA. Spectrophotometric method for the quantitative analysis of carbarsone in turkey feed. Bull Environ Contam Toxicol. 1983 Aug;31(2):235-8. PubMed PMID: 6684489.

8: Verburgh-van der Zwan N, van Ketel WG. Allergic drug eruption to carbason. Contact Dermatitis. 1981 Sep;7(5):274-5. PubMed PMID: 7307487.

9: McDougald LR. Efficacy and compatibility of amprolium and carbarsone against Coccidiosis and blackhead in turkeys. Poult Sci. 1979 Jan;58(1):76-80. PubMed PMID: 572970.

10: Hoodless RA, Tarrant KR. Residues of prophylactics in animal products. 3. The determination of carbarsone in poultry meat. Analyst. 1973 Jul;98(168):502-5. PubMed PMID: 4733226.

11: Worden AN, Wood EC. The effect of Carbarsone (33.6 per cent w-v p-ureidobenzene arsonic acid) on bodyweight gain, food conversion and tissue arsenic levels of turkey poults. J Sci Food Agric. 1973 Jan;24(1):35-41. PubMed PMID: 4696593.

12: Sullivan TW, al-Timimi AA. Safety and toxicity of dietary organic arsenicals relative to performance of young turkeys. 2. Carbarsone. Poult Sci. 1972 Sep;51(5):1498-501. PubMed PMID: 4674925.

13: The determination of carbarsone in animal feeds. Analyst. 1971 Nov;96(148):817-23. PubMed PMID: 5130425.

14: Weston RE, Wheals BB, Kensett MJ. The gas-chromatographic determination of arsanilic acid and carbarsone in animal feeding stuffs. Analyst. 1971 Aug;96(145):601-3. PubMed PMID: 5132074.

15: Cho KM, Lee JY, Soh CT. Virulence Of Entamoeba Histolytica According To The Strains In Korea: III. Amebicial Response Of Antiamoebic Agents On Several Strains Of Entamoeba Histolytica In Vitro. Kisaengchunghak Chapchi. 1969 Dec;7(3):121-128. PubMed PMID: 12913525.

16: ALBORNOZ PLATA A. [Erythromycin-carbarsone in the treatment of amebiasis]. Rev Fac Med Univ Nac Colomb. 1959 Oct-Dec;27:235-44. Spanish. PubMed PMID: 13792418.

17: LAPIN LN. [Application of diphenylcarbasone in photometric microdetermination of copper in the blood, urine and tissues]. Biokhimiia. 1957 Sep-Oct;22(5):825-9. Russian. PubMed PMID: 13499457.

18: RADKE RA, BAROODY WG. Carbarsone toxicity: a review of the literature and report of 45 cases. Ann Intern Med. 1957 Sep;47(3):418-27. PubMed PMID: 13459121.

19: SHERSHIN PH, DAVIS VT. Toxicity of carbarsone as an anti-amebic. J Med Soc N J. 1957 Jul;54(7):322-3. PubMed PMID: 13439356.

20: ALVAREZ EA, RIVERA TORRES M. Evaluation of bacitracin and bacitracin methylene disalicylate with carbarsone in the treatment of amebiasis. Antibiot Annu. 1957-1958;5:992-5. PubMed PMID: 13521927.