Propyl gallate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592059

CAS#: 121-79-9

Description: Propyl gallate is an antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.

Chemical Structure

Propyl gallate
CAS# 121-79-9

Theoretical Analysis

MedKoo Cat#: 592059
Name: Propyl gallate
CAS#: 121-79-9
Chemical Formula: C10H12O5
Exact Mass: 212.07
Molecular Weight: 212.200
Elemental Analysis: C, 56.60; H, 5.70; O, 37.70

Price and Availability

Size Price Availability Quantity
25g USD 230
500g USD 650
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Synonym: Propyl gallate; NSC 2626; NSC-2626; NSC2626

IUPAC/Chemical Name: Gallic acid, propyl ester


InChi Code: InChI=1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 212.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sumi C, Okamoto A, Tanaka H, Kusunoki M, Shoji T, Uba T, Adachi T, Iwai T, Nishi K, Harada H, Bono H, Matsuo Y, Hirota K. Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity. Sci Rep. 2018 Jun 12;8(1):8987. doi: 10.1038/s41598-018-27220-8. PubMed PMID: 29895831; PubMed Central PMCID: PMC5997661.

2: Cui H, Tao F, Hou Y, Lu Y, Zheng T, Sang S, Lv L. Dual effects of propyl gallate and its methylglyoxal adduct on carbonyl stress and oxidative stress. Food Chem. 2018 Nov 1;265:227-232. doi: 10.1016/j.foodchem.2018.04.045. Epub 2018 Apr 16. PubMed PMID: 29884377.

3: Cavalcanti RMF, Jorge JA, Guimarães LHS. Characterization of Aspergillus fumigatus CAS-21 tannase with potential for propyl gallate synthesis and treatment of tannery effluent from leather industry. 3 Biotech. 2018 Jun;8(6):270. doi: 10.1007/s13205-018-1294-z. Epub 2018 May 25. PubMed PMID: 29868308; PubMed Central PMCID: PMC5970104.

4: Martinez-Perez DA, Jimenez-Del-Rio M, Velez-Pardo C. Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster. Neurotox Res. 2018 Apr 17. doi: 10.1007/s12640-018-9899-x. [Epub ahead of print] Erratum in: Neurotox Res. 2018 Jun 1;:. PubMed PMID: 29667128.

5: Yue X, Liu L, Li Z, Yang Q, Zhu W, Zhang W, Wang J. Highly specific and sensitive determination of propyl gallate in food by a novel fluorescence sensor. Food Chem. 2018 Aug 1;256:45-52. doi: 10.1016/j.foodchem.2018.02.108. Epub 2018 Feb 21. PubMed PMID: 29606471.

6: Zhang WW, Xu F, Wang D, Ye J, Cai SQ. Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences. Chin J Nat Med. 2018 Mar;16(3):194-202. doi: 10.1016/S1875-5364(18)30047-5. PubMed PMID: 29576055.

7: Pop A, Drugan T, Gutleb AC, Lupu D, Cherfan J, Loghin F, Kiss B. Estrogenic and anti-estrogenic activity of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate and their binary mixtures on two estrogen responsive cell lines (T47D-Kbluc, MCF-7). J Appl Toxicol. 2018 Jul;38(7):944-957. doi: 10.1002/jat.3601. Epub 2018 Feb 19. PubMed PMID: 29460325.

8: Baran A, Köktürk M, Atamanalp M, Ceyhun SB. Determination of developmental toxicity of zebrafish exposed to propyl gallate dosed lower than ADI (Acceptable Daily Intake). Regul Toxicol Pharmacol. 2018 Apr;94:16-21. doi: 10.1016/j.yrtph.2017.12.027. Epub 2018 Jan 3. PubMed PMID: 29305948.

9: Li Q, Pu H, Tang P, Tang B, Sun Q, Li H. Propyl gallate/cyclodextrin supramolecular complexes with enhanced solubility and radical scavenging capacity. Food Chem. 2018 Apr 15;245:1062-1069. doi: 10.1016/j.foodchem.2017.11.065. Epub 2017 Nov 16. PubMed PMID: 29287323.

10: Sun Q, Yang H, Tang P, Liu J, Wang W, Li H. Interactions of cinnamaldehyde and its metabolite cinnamic acid with human serum albumin and interference of other food additives. Food Chem. 2018 Mar 15;243:74-81. doi: 10.1016/j.foodchem.2017.09.109. Epub 2017 Sep 21. PubMed PMID: 29146372.

11: Bavol D, Economou A, Zima J, Barek J, Dejmkova H. Simultaneous determination of tert-butylhydroquinone, propyl gallate, and butylated hydroxyanisole by flow-injection analysis with multiple-pulse amperometric detection. Talanta. 2018 Feb 1;178:231-236. doi: 10.1016/j.talanta.2017.09.032. Epub 2017 Sep 12. PubMed PMID: 29136816.

12: Yang JT, Lee IN, Lu FJ, Chung CY, Lee MH, Cheng YC, Chen KT, Chen CH. Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway. J Immunol Res. 2017;2017:9489383. doi: 10.1155/2017/9489383. Epub 2017 Sep 14. PubMed PMID: 29062841; PubMed Central PMCID: PMC5618759.

13: Einali A. The induction of salt stress tolerance by propyl gallate treatment in green microalga Dunaliella bardawil, through enhancing ascorbate pool and antioxidant enzymes activity. Protoplasma. 2018 Mar;255(2):601-611. doi: 10.1007/s00709-017-1173-1. Epub 2017 Oct 8. PubMed PMID: 28990124.

14: Yang C, Lim W, Bazer FW, Song G. Propyl gallate induces cell death and inhibits invasion of human trophoblasts by blocking the AKT and mitogen-activated protein kinase pathways. Food Chem Toxicol. 2017 Nov;109(Pt 1):497-504. doi: 10.1016/j.fct.2017.09.049. Epub 2017 Sep 30. PubMed PMID: 28974438.

15: Goupil P, Benouaret R, Richard C. Ethyl Gallate Displays Elicitor Activities in Tobacco Plants. J Agric Food Chem. 2017 Oct 18;65(41):9006-9012. doi: 10.1021/acs.jafc.7b03051. Epub 2017 Oct 6. PubMed PMID: 28960978.

16: Lin Y, Lin Y, Lin H, Chen Y, Wang H, Shi J. Application of propyl gallate alleviates pericarp browning in harvested longan fruit by modulating metabolisms of respiration and energy. Food Chem. 2018 Feb 1;240:863-869. doi: 10.1016/j.foodchem.2017.07.118. Epub 2017 Jul 25. PubMed PMID: 28946353.

17: Glembockyte V, Cosa G. Redox-Based Photostabilizing Agents in Fluorescence Imaging: The Hidden Role of Intersystem Crossing in Geminate Radical Ion Pairs. J Am Chem Soc. 2017 Sep 20;139(37):13227-13233. doi: 10.1021/jacs.7b08134. Epub 2017 Sep 8. PubMed PMID: 28853869.

18: Wang Q, de Oliveira EF, Alborzi S, Bastarrachea LJ, Tikekar RV. On mechanism behind UV-A light enhanced antibacterial activity of gallic acid and propyl gallate against Escherichia coli O157:H7. Sci Rep. 2017 Aug 16;7(1):8325. doi: 10.1038/s41598-017-08449-1. PubMed PMID: 28814799; PubMed Central PMCID: PMC5559599.

19: Sztanke M, Sztanke K. Biologically important hydrazide-containing fused azaisocytosines as antioxidant agents. Redox Rep. 2017 Nov;22(6):572-581. doi: 10.1080/13510002.2017.1364330. Epub 2017 Aug 16. PubMed PMID: 28812524.

20: Topal A, Çomakli S, Özkaraca M, Baran A, Köktürk M, Parlak V, Sağlam YS, Atamanalp M, Ceyhun SB. Immunofluorescence evaluation of 4-hydroxynonenal and 8-hydroxy-2-deoxyguanosine activation in zebrafish (Daino rerio) larvae brain exposed (microinjected) to propyl gallate. Chemosphere. 2017 Sep;183:252-256. doi: 10.1016/j.chemosphere.2017.05.110. Epub 2017 May 19. PubMed PMID: 28550782.